taurochenodeoxycholic-acid and Dry-Eye-Syndromes

Tear hyperosmolarity plays an essential role in the initiation and progression of dry-eye disease. Under a hyperosmotic environment, corneal epithelial cells experience perturbations in endoplasmic reticulum function that can lead to proinflammatory signaling and apoptosis. In this study, we investigated the effect of tauroursodeoxycholic acid (TUDCA), a chemical chaperone known to protect against endoplasmic reticulum stress, on corneal epithelial cells exposed to hyperosmotic conditions. We found that the expression of the genes involved in the activation of the unfolded protein response and the pro-apoptotic transcription factor

Topics: Apoptosis; Dry Eye Syndromes; Endoplasmic Reticulum Stress; Epithelial Cells; Humans; Taurochenodeoxycholic Acid; Unfolded Protein Response