Page last updated: 2024-10-20

taurine and Short Bowel Syndrome

taurine has been researched along with Short Bowel Syndrome in 5 studies

Short Bowel Syndrome: A malabsorption syndrome resulting from extensive operative resection of the SMALL INTESTINE, the absorptive region of the GASTROINTESTINAL TRACT.

Research Excerpts

ExcerptRelevanceReference
" Incidence and type of sepsis were reviewed for 8 to 12 months pre- (when heparin was used) and 2 to 33 months postintroduction of the taurolidine catheter lock."3.78Significant reduction in central venous catheter-related bloodstream infections in children on HPN after starting treatment with taurolidine line lock. ( Brind, J; Chu, HP; Hill, S; Tomar, R, 2012)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Merras-Salmio, L1
Mutanen, A1
Ylinen, E1
Rintala, R1
Koivusalo, A1
Pakarinen, MP1
Chu, HP1
Brind, J1
Tomar, R1
Hill, S1
Schneider, SM1
Joly, F1
Gehrardt, MF1
Badran, AM1
Myara, A1
Thuillier, F1
Coudray-Lucas, C1
Cynober, L1
Trivin, F1
Messing, B1
Meehan, JJ1
Georgeson, KE1
Helms, RA1
Storm, MC1
Christensen, ML1
Hak, EB1
Chesney, RW1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Expanded Access Use of Omegaven® in the Treatment of Parenteral Nutrition Induced Liver Injury in Children[NCT02925520]0 participants Expanded AccessNo longer available
Compassionate Use of an Intravenous Fat Emulsion Comprised of Fish Oil in the Treatment of Parenteral Nutrition Induced Liver Injury in Infants[NCT00738101]293 participants (Actual)Interventional2008-09-30Completed
Research Study of an Intravenous Fat Emulsion Comprised of Fish Oils (Omegaven) in the Treatment of Parenteral Nutrition (PN) Induced Liver Injury[NCT01089426]90 participants (Actual)Interventional2008-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

All Cause Mortality During the Study.

To describe proportion of infants who died secondary to any cause, related or unrelated to Fish Oil Emulsion. (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).

InterventionParticipants (Count of Participants)
Fish Oil Emulsion Arm30

All-cause Mortality up to Hospital Discharge

To describe number and percentage of infants who died secondary to any cause, related or unrelated to Fish Oil Emulsion. (NCT00738101)
Timeframe: Anytime from initiation of study to discharge from the hospital.

InterventionParticipants (Count of Participants)
Fish Oil Emulsion Arm40

Growth Z-scores for Weight

The Z-score indicated the number of standard deviations away from the mean. A weight Z-score of 0 is equal to the mean. A weight Z-score of ≤ -2 indicates an underweight status, while a weight Z-score of ≥ 2 indicates overweight or obese status. (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).

Interventionz-score (Mean)
Fish Oil Emulsion Arm-1.48

Liver or Multi-visceral Transplant

To describe the number and percentage of infants who required liver or multi-visceral transplant. (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).

InterventionParticipants (Count of Participants)
Fish Oil Emulsion Arm2

Time to Resolution of Parenteral Nutrition Associated Cholestasis Prior to End of Study

Time in days from the initiation of fish oil emulsions (initiation of study) until resolution of cholestasis as defined by serum conjugated bilirubin≤ 2 mg/dL prior to EOS (end of study). (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).

InterventionDays (Mean)
Fish Oil Emulsion Arm38.02

Trials

1 trial available for taurine and Short Bowel Syndrome

ArticleYear
Taurine status and response to intravenous taurine supplementation in adults with short-bowel syndrome undergoing long-term parenteral nutrition: a pilot study.
    The British journal of nutrition, 2006, Volume: 96, Issue:2

    Topics: Adult; Amino Acids; Bile Acids and Salts; Cholestasis, Intrahepatic; Chronic Disease; Epidemiologic

2006

Other Studies

4 other studies available for taurine and Short Bowel Syndrome

ArticleYear
Pediatric Intestinal Failure: The Key Outcomes for the First 100 Patients Treated in a National Tertiary Referral Center During 1984-2017.
    JPEN. Journal of parenteral and enteral nutrition, 2018, Volume: 42, Issue:8

    Topics: Catheter-Related Infections; Child; Child, Preschool; Digestive System Surgical Procedures; Female;

2018
Significant reduction in central venous catheter-related bloodstream infections in children on HPN after starting treatment with taurolidine line lock.
    Journal of pediatric gastroenterology and nutrition, 2012, Volume: 55, Issue:4

    Topics: Adolescent; Adult; Anti-Infective Agents; Anticoagulants; Catheter-Related Infections; Catheterizati

2012
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
    Journal of pediatric surgery, 1997, Volume: 32, Issue:3

    Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto

1997
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
    Journal of pediatric surgery, 1997, Volume: 32, Issue:3

    Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto

1997
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
    Journal of pediatric surgery, 1997, Volume: 32, Issue:3

    Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto

1997
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
    Journal of pediatric surgery, 1997, Volume: 32, Issue:3

    Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto

1997
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
    Journal of pediatric surgery, 1997, Volume: 32, Issue:3

    Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto

1997
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
    Journal of pediatric surgery, 1997, Volume: 32, Issue:3

    Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto

1997
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
    Journal of pediatric surgery, 1997, Volume: 32, Issue:3

    Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto

1997
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
    Journal of pediatric surgery, 1997, Volume: 32, Issue:3

    Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto

1997
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
    Journal of pediatric surgery, 1997, Volume: 32, Issue:3

    Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto

1997
Cysteine supplementation results in normalization of plasma taurine concentrations in children receiving home parenteral nutrition.
    The Journal of pediatrics, 1999, Volume: 134, Issue:3

    Topics: Amino Acids, Sulfur; Child; Child, Preschool; Cysteine; Dose-Response Relationship, Drug; Female; Hu

1999