taurine has been researched along with Pancreatic Neoplasms in 9 studies
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Importantly, angiotensin II (AngII), independently of its vasoconstrictor action, causes β-cell inflammation and dysfunction, which may be an early step in the development of type 2 diabetes." | 3.85 | Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response. ( Chan, SMH; Herbert, TP; Ku, JM; Lau, YS; Miller, AA; Potocnik, S; Woodman, OL; Ye, JM, 2017) |
| "Human pancreatic cancer cell lines representing diverse states of differentiation were exposed to TRD for 24 h." | 1.40 | Taurolidine induces epithelial-mesenchymal transition via up-regulation of the transcription factor Snail in human pancreatic cancer cell lines. ( Arndt, M; Buhr, HJ; Erben, U; Hotz, B; Hotz, HG, 2014) |
| "The prognosis for patients with pancreatic cancer is extremely poor, as evidenced by the disease's five-year survival rate of ~5%." | 1.40 | HR-MAS MRS of the pancreas reveals reduced lipid and elevated lactate and taurine associated with early pancreatic cancer. ( Bergers, G; Firpo, MA; Izquierdo-Garcia, JL; Lodi, A; Mulvihill, SJ; Rivera, LB; Ronen, SM; Tempero, MA; Wang, AS, 2014) |
| "Furthermore the number of liver metastasis per animal was reduced after lavage with taurolidin (2 +/- 2) and Octreotide (2." | 1.33 | Impact of taurolidin and octreotide on liver metastasis and lipid peroxidation after laparoscopy in chemical induced ductal pancreatic cancer. ( Braumann, C; Gregor, JI; Guski, H; Heukamp, I; Jacobi, CA; Kilian, M; Schimke, I; Walz, MK; Wenger, FA, 2005) |
| "Human pancreatic cancer cells (Capan-1 cell line) were heterotransplanted subcutaneously into nude mice." | 1.29 | Combined magnetic resonance imaging and spectrometry for characterization of human pancreatic adenocarcinoma (Capan-1) heterotransplanted in nude mice. ( Chemin-Thomas, C; Esclassan, J; Hollande, E; Palévody, C, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chan, SMH | 1 |
| Lau, YS | 1 |
| Miller, AA | 1 |
| Ku, JM | 1 |
| Potocnik, S | 1 |
| Ye, JM | 1 |
| Woodman, OL | 1 |
| Herbert, TP | 1 |
| Fragai, M | 1 |
| Comito, G | 1 |
| Di Cesare Mannelli, L | 1 |
| Gualdani, R | 1 |
| Calderone, V | 1 |
| Louka, A | 1 |
| Richichi, B | 1 |
| Francesconi, O | 1 |
| Angeli, A | 1 |
| Nocentini, A | 1 |
| Gratteri, P | 1 |
| Chiarugi, P | 1 |
| Ghelardini, C | 1 |
| Tadini-Buoninsegni, F | 1 |
| Supuran, CT | 1 |
| Nativi, C | 1 |
| Hotz, B | 1 |
| Erben, U | 1 |
| Arndt, M | 1 |
| Buhr, HJ | 1 |
| Hotz, HG | 1 |
| Wang, AS | 1 |
| Lodi, A | 1 |
| Rivera, LB | 1 |
| Izquierdo-Garcia, JL | 1 |
| Firpo, MA | 1 |
| Mulvihill, SJ | 1 |
| Tempero, MA | 1 |
| Bergers, G | 1 |
| Ronen, SM | 1 |
| Tesiram, YA | 1 |
| Lerner, M | 1 |
| Stewart, C | 1 |
| Njoku, C | 1 |
| Brackett, DJ | 1 |
| Rudolph, G | 1 |
| Kloeters-Plachky, P | 1 |
| Sauer, P | 1 |
| Stiehl, A | 1 |
| Kilian, M | 2 |
| Gregor, JI | 1 |
| Heukamp, I | 1 |
| Braumann, C | 2 |
| Guski, H | 2 |
| Schimke, I | 1 |
| Walz, MK | 1 |
| Jacobi, CA | 2 |
| Wenger, FA | 2 |
| Chemin-Thomas, C | 1 |
| Palévody, C | 1 |
| Esclassan, J | 1 |
| Hollande, E | 1 |
| Neumann, A | 1 |
| Ridders, J | 1 |
| Peter, FJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blind Multicenter Pilot Study vs. Placebo for the Evaluation of Efficacy and Tolerability of Tauroursodeoxycholic Acid Administered by Oral Route as Add on Treatment in Patients Affected by Amyotrophic Lateral Sclerosis[NCT00877604] | Phase 2 | 34 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Responder patients were defined as those subjects showing an improvement of at least 15% in the ALSFRS-R slope during the treatment period as compared to the lead-in period. (NCT00877604)
Timeframe: 1 year
| Intervention | participants (Number) |
|---|---|
| TUDCA | 13 |
| Placebo | 6 |
1 trial available for taurine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Intestinal absorption and biliary secretion of ursodeoxycholic acid and its taurine conjugate.
Topics: Aged; Analysis of Variance; Bile Acids and Salts; Bile Ducts; Cholestasis, Extrahepatic; Female; Hum | 2002 |
8 other studies available for taurine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response.
Topics: Angiotensin II; Animals; Cell Line, Tumor; Cytokines; Diabetes Mellitus, Type 2; eIF-2 Kinase; Endop | 2017 |
Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).
Topics: Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Cell Line, Tumor; Drug | 2017 |
Taurolidine induces epithelial-mesenchymal transition via up-regulation of the transcription factor Snail in human pancreatic cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Survival; Dose-Re | 2014 |
HR-MAS MRS of the pancreas reveals reduced lipid and elevated lactate and taurine associated with early pancreatic cancer.
Topics: Animals; Carcinoma, Pancreatic Ductal; Early Diagnosis; Genes, ras; Humans; Lactates; Lipids; Lipopo | 2014 |
Utility of nuclear magnetic resonance spectroscopy for pancreatic cancer studies.
Topics: Biomarkers, Tumor; Blood Glucose; Case-Control Studies; Choline; Fatty Acids, Unsaturated; Female; H | 2012 |
Impact of taurolidin and octreotide on liver metastasis and lipid peroxidation after laparoscopy in chemical induced ductal pancreatic cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Cricetinae; Laparoscop | 2005 |
Combined magnetic resonance imaging and spectrometry for characterization of human pancreatic adenocarcinoma (Capan-1) heterotransplanted in nude mice.
Topics: Adenocarcinoma; Animals; Fatty Acids, Unsaturated; Glycerylphosphorylcholine; Humans; Magnetic Reson | 1994 |
Effects of taurolidine and octreotide on port site and liver metastasis after laparoscopy in an animal model of pancreatic cancer.
Topics: Animals; Antineoplastic Agents; Biopsy; Carcinoma, Pancreatic Ductal; Cricetinae; Diet; Laparoscopy; | 2002 |