taurine has been researched along with MELAS in 7 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Post-transcriptional taurine modification at the first anticodon ("wobble") nucleotide is deficient in A3243G-mutant mitochondrial (mt) tRNA(Leu(UUR)) of patients with myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 7.78 | Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS. ( Ichimiya, H; Kamimura, N; Nishimaki, K; Nishimatsu, S; Ohsawa, Y; Ohta, S; Rikimaru, M; Sunada, Y; Wolf, AM, 2012) |
| "Taurine serves as a substrate in the formation of 5-taurinomethyluridine-tRNA(Leu(UUR)); therefore, taurine deficiency should mimic 5-taurinomethyluridine-tRNA(Leu(UUR)) deficiency." | 6.49 | Taurine deficiency and MELAS are closely related syndromes. ( Azuma, J; Ito, T; Jong, CJ; Schaffer, SW; Warner, D, 2013) |
| "In MELAS, taurine modification defect in the anticodon of mitochondrial leucine tRNA causes codon translation failure." | 4.31 | [Therapeutics for Mitochondrial Encephalomyopathy]. ( Sunada, Y, 2023) |
| "Post-transcriptional taurine modification at the first anticodon ("wobble") nucleotide is deficient in A3243G-mutant mitochondrial (mt) tRNA(Leu(UUR)) of patients with myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 3.78 | Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS. ( Ichimiya, H; Kamimura, N; Nishimaki, K; Nishimatsu, S; Ohsawa, Y; Ohta, S; Rikimaru, M; Sunada, Y; Wolf, AM, 2012) |
| " We report here that mitochondrial tRNAs(Leu(UUR)) harboring one of five mutations found in tissues from patients with symptoms of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) (A3243G, G3244A, T3258C, T3271C, and T3291C) lacked the normal taurine-containing modification (5-taurinomethyluridine) at the anticodon wobble position." | 3.73 | Specific correlation between the wobble modification deficiency in mutant tRNAs and the clinical features of a human mitochondrial disease. ( Arenas, J; Campos, Y; Goto, Y; Kirino, Y; Suzuki, T, 2005) |
| "Taurine serves as a substrate in the formation of 5-taurinomethyluridine-tRNA(Leu(UUR)); therefore, taurine deficiency should mimic 5-taurinomethyluridine-tRNA(Leu(UUR)) deficiency." | 2.49 | Taurine deficiency and MELAS are closely related syndromes. ( Azuma, J; Ito, T; Jong, CJ; Schaffer, SW; Warner, D, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Sunada, Y | 3 |
| Ueda, S | 1 |
| Yagi, M | 1 |
| Tomoda, E | 1 |
| Matsumoto, S | 1 |
| Ueyanagi, Y | 1 |
| Do, Y | 1 |
| Setoyama, D | 1 |
| Matsushima, Y | 1 |
| Nagao, A | 1 |
| Suzuki, T | 2 |
| Ide, T | 1 |
| Mori, Y | 1 |
| Oyama, N | 1 |
| Kang, D | 1 |
| Uchiumi, T | 1 |
| Ohsawa, Y | 2 |
| Hagiwara, H | 1 |
| Nishimatsu, SI | 1 |
| Hirakawa, A | 1 |
| Kamimura, N | 2 |
| Ohtsubo, H | 1 |
| Fukai, Y | 1 |
| Murakami, T | 1 |
| Koga, Y | 1 |
| Goto, YI | 1 |
| Ohta, S | 2 |
| Windpessl, M | 1 |
| Müller, P | 1 |
| Rikimaru, M | 1 |
| Wolf, AM | 1 |
| Nishimaki, K | 1 |
| Ichimiya, H | 1 |
| Nishimatsu, S | 1 |
| Schaffer, SW | 1 |
| Jong, CJ | 1 |
| Warner, D | 1 |
| Ito, T | 1 |
| Azuma, J | 1 |
| Kirino, Y | 1 |
| Goto, Y | 1 |
| Campos, Y | 1 |
| Arenas, J | 1 |
1 review available for taurine and MELAS
| Article | Year |
|---|---|
Taurine deficiency and MELAS are closely related syndromes.
Topics: Animals; Growth and Development; Humans; MELAS Syndrome; Organ Specificity; Taurine | 2013 |
1 trial available for taurine and MELAS
| Article | Year |
|---|---|
Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial.
Topics: Administration, Oral; Adolescent; Adult; Dietary Supplements; Female; Humans; Male; MELAS Syndrome; | 2019 |
5 other studies available for taurine and MELAS
| Article | Year |
|---|---|
[Therapeutics for Mitochondrial Encephalomyopathy].
Topics: Arginine; Humans; MELAS Syndrome; Mitochondria; Stroke; Taurine | 2023 |
Mitochondrial haplotype mutation alleviates respiratory defect of MELAS by restoring taurine modification in tRNA with 3243A > G mutation.
Topics: DNA, Mitochondrial; Haplotypes; Humans; MELAS Syndrome; Mitochondrial Diseases; Mutation; RNA, Trans | 2023 |
Valproic acid and MELAS: a word of warning.
Topics: Female; Humans; MELAS Syndrome; Mitochondria; Stroke; Taurine | 2013 |
Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS.
Topics: Adult; Cells, Cultured; Female; Humans; MELAS Syndrome; Mitochondria; Stroke; Taurine; Young Adult | 2012 |
Specific correlation between the wobble modification deficiency in mutant tRNAs and the clinical features of a human mitochondrial disease.
Topics: Anticodon; Base Pairing; Base Sequence; DNA Primers; DNA, Mitochondrial; HeLa Cells; Humans; MELAS S | 2005 |