taurine has been researched along with MELAS Syndrome in 7 studies
MELAS Syndrome: A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Post-transcriptional taurine modification at the first anticodon ("wobble") nucleotide is deficient in A3243G-mutant mitochondrial (mt) tRNA(Leu(UUR)) of patients with myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 7.78 | Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS. ( Ichimiya, H; Kamimura, N; Nishimaki, K; Nishimatsu, S; Ohsawa, Y; Ohta, S; Rikimaru, M; Sunada, Y; Wolf, AM, 2012) |
| "Taurine serves as a substrate in the formation of 5-taurinomethyluridine-tRNA(Leu(UUR)); therefore, taurine deficiency should mimic 5-taurinomethyluridine-tRNA(Leu(UUR)) deficiency." | 6.49 | Taurine deficiency and MELAS are closely related syndromes. ( Azuma, J; Ito, T; Jong, CJ; Schaffer, SW; Warner, D, 2013) |
| "In MELAS, taurine modification defect in the anticodon of mitochondrial leucine tRNA causes codon translation failure." | 4.31 | [Therapeutics for Mitochondrial Encephalomyopathy]. ( Sunada, Y, 2023) |
| "Post-transcriptional taurine modification at the first anticodon ("wobble") nucleotide is deficient in A3243G-mutant mitochondrial (mt) tRNA(Leu(UUR)) of patients with myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 3.78 | Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS. ( Ichimiya, H; Kamimura, N; Nishimaki, K; Nishimatsu, S; Ohsawa, Y; Ohta, S; Rikimaru, M; Sunada, Y; Wolf, AM, 2012) |
| " We report here that mitochondrial tRNAs(Leu(UUR)) harboring one of five mutations found in tissues from patients with symptoms of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) (A3243G, G3244A, T3258C, T3271C, and T3291C) lacked the normal taurine-containing modification (5-taurinomethyluridine) at the anticodon wobble position." | 3.73 | Specific correlation between the wobble modification deficiency in mutant tRNAs and the clinical features of a human mitochondrial disease. ( Arenas, J; Campos, Y; Goto, Y; Kirino, Y; Suzuki, T, 2005) |
| "Taurine serves as a substrate in the formation of 5-taurinomethyluridine-tRNA(Leu(UUR)); therefore, taurine deficiency should mimic 5-taurinomethyluridine-tRNA(Leu(UUR)) deficiency." | 2.49 | Taurine deficiency and MELAS are closely related syndromes. ( Azuma, J; Ito, T; Jong, CJ; Schaffer, SW; Warner, D, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Sunada, Y | 3 |
| Ueda, S | 1 |
| Yagi, M | 1 |
| Tomoda, E | 1 |
| Matsumoto, S | 1 |
| Ueyanagi, Y | 1 |
| Do, Y | 1 |
| Setoyama, D | 1 |
| Matsushima, Y | 1 |
| Nagao, A | 1 |
| Suzuki, T | 2 |
| Ide, T | 1 |
| Mori, Y | 1 |
| Oyama, N | 1 |
| Kang, D | 1 |
| Uchiumi, T | 1 |
| Ohsawa, Y | 2 |
| Hagiwara, H | 1 |
| Nishimatsu, SI | 1 |
| Hirakawa, A | 1 |
| Kamimura, N | 2 |
| Ohtsubo, H | 1 |
| Fukai, Y | 1 |
| Murakami, T | 1 |
| Koga, Y | 1 |
| Goto, YI | 1 |
| Ohta, S | 2 |
| Windpessl, M | 1 |
| Müller, P | 1 |
| Rikimaru, M | 1 |
| Wolf, AM | 1 |
| Nishimaki, K | 1 |
| Ichimiya, H | 1 |
| Nishimatsu, S | 1 |
| Schaffer, SW | 1 |
| Jong, CJ | 1 |
| Warner, D | 1 |
| Ito, T | 1 |
| Azuma, J | 1 |
| Kirino, Y | 1 |
| Goto, Y | 1 |
| Campos, Y | 1 |
| Arenas, J | 1 |
1 review available for taurine and MELAS Syndrome
| Article | Year |
|---|---|
Taurine deficiency and MELAS are closely related syndromes.
Topics: Animals; Growth and Development; Humans; MELAS Syndrome; Organ Specificity; Taurine | 2013 |
1 trial available for taurine and MELAS Syndrome
| Article | Year |
|---|---|
Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial.
Topics: Administration, Oral; Adolescent; Adult; Dietary Supplements; Female; Humans; Male; MELAS Syndrome; | 2019 |
5 other studies available for taurine and MELAS Syndrome
| Article | Year |
|---|---|
[Therapeutics for Mitochondrial Encephalomyopathy].
Topics: Arginine; Humans; MELAS Syndrome; Mitochondria; Stroke; Taurine | 2023 |
Mitochondrial haplotype mutation alleviates respiratory defect of MELAS by restoring taurine modification in tRNA with 3243A > G mutation.
Topics: DNA, Mitochondrial; Haplotypes; Humans; MELAS Syndrome; Mitochondrial Diseases; Mutation; RNA, Trans | 2023 |
Valproic acid and MELAS: a word of warning.
Topics: Female; Humans; MELAS Syndrome; Mitochondria; Stroke; Taurine | 2013 |
Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS.
Topics: Adult; Cells, Cultured; Female; Humans; MELAS Syndrome; Mitochondria; Stroke; Taurine; Young Adult | 2012 |
Specific correlation between the wobble modification deficiency in mutant tRNAs and the clinical features of a human mitochondrial disease.
Topics: Anticodon; Base Pairing; Base Sequence; DNA Primers; DNA, Mitochondrial; HeLa Cells; Humans; MELAS S | 2005 |