taurine has been researched along with Liver Failure in 5 studies
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Taurine treatment was effective in counteracting APAP-induced hepatic damages, oxidative stress and cellular necrosis." | 5.36 | Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. ( Das, J; Ghosh, J; Manna, P; Sil, PC, 2010) |
| "By contrast, rats with hepatic encephalopathy (HE) following administration of a hepatotoxin, thioacetamide, were characterized by CC edema and an increased Tau content in both BG and CC." | 5.29 | Relation of taurine transport and brain edema in rats with simple hyperammonemia or liver failure. ( Albrecht, J; Hilgier, W; Olson, JE, 1996) |
| "Taurine treatment was effective in counteracting APAP-induced hepatic damages, oxidative stress and cellular necrosis." | 1.36 | Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. ( Das, J; Ghosh, J; Manna, P; Sil, PC, 2010) |
| "By contrast, rats with hepatic encephalopathy (HE) following administration of a hepatotoxin, thioacetamide, were characterized by CC edema and an increased Tau content in both BG and CC." | 1.29 | Relation of taurine transport and brain edema in rats with simple hyperammonemia or liver failure. ( Albrecht, J; Hilgier, W; Olson, JE, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, J | 1 |
| Ghosh, J | 1 |
| Manna, P | 1 |
| Sil, PC | 1 |
| Panatto, JP | 1 |
| Jeremias, IC | 1 |
| Ferreira, GK | 1 |
| Ramos, AC | 1 |
| Rochi, N | 1 |
| Gonçalves, CL | 1 |
| Daufenbach, JF | 1 |
| Jeremias, GC | 1 |
| Carvalho-Silva, M | 1 |
| Rezin, GT | 1 |
| Scaini, G | 1 |
| Streck, EL | 1 |
| Hilgier, W | 2 |
| Olson, JE | 1 |
| Albrecht, J | 2 |
| Meehan, JJ | 1 |
| Georgeson, KE | 1 |
| Zielińska, M | 1 |
| Januszewski, S | 1 |
| Hesselink, M | 1 |
| Quack, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Expanded Access Use of Omegaven® in the Treatment of Parenteral Nutrition Induced Liver Injury in Children[NCT02925520] | 0 participants | Expanded Access | No longer available | ||||
| Compassionate Use of an Intravenous Fat Emulsion Comprised of Fish Oil in the Treatment of Parenteral Nutrition Induced Liver Injury in Infants[NCT00738101] | 293 participants (Actual) | Interventional | 2008-09-30 | Completed | |||
| Research Study of an Intravenous Fat Emulsion Comprised of Fish Oils (Omegaven) in the Treatment of Parenteral Nutrition (PN) Induced Liver Injury[NCT01089426] | 90 participants (Actual) | Interventional | 2008-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To describe proportion of infants who died secondary to any cause, related or unrelated to Fish Oil Emulsion. (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).
| Intervention | Participants (Count of Participants) |
|---|---|
| Fish Oil Emulsion Arm | 30 |
To describe number and percentage of infants who died secondary to any cause, related or unrelated to Fish Oil Emulsion. (NCT00738101)
Timeframe: Anytime from initiation of study to discharge from the hospital.
| Intervention | Participants (Count of Participants) |
|---|---|
| Fish Oil Emulsion Arm | 40 |
The Z-score indicated the number of standard deviations away from the mean. A weight Z-score of 0 is equal to the mean. A weight Z-score of ≤ -2 indicates an underweight status, while a weight Z-score of ≥ 2 indicates overweight or obese status. (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).
| Intervention | z-score (Mean) |
|---|---|
| Fish Oil Emulsion Arm | -1.48 |
To describe the number and percentage of infants who required liver or multi-visceral transplant. (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).
| Intervention | Participants (Count of Participants) |
|---|---|
| Fish Oil Emulsion Arm | 2 |
Time in days from the initiation of fish oil emulsions (initiation of study) until resolution of cholestasis as defined by serum conjugated bilirubin≤ 2 mg/dL prior to EOS (end of study). (NCT00738101)
Timeframe: From initiation to end of study (End of Study : Discontinuation of Fish Oil Emulsion, Death, Transplant, or Discharge from the hospital, whichever is achieved first, up to 5 years).
| Intervention | Days (Mean) |
|---|---|
| Fish Oil Emulsion Arm | 38.02 |
5 other studies available for taurine and Liver Failure
| Article | Year |
|---|---|
Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cell Separation; Cytochrome P-450 CYP2E1; DNA Frag | 2010 |
Inhibition of mitochondrial respiratory chain in the brain of rats after hepatic failure induced by acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antioxidants; Brain; Deferoxamine; | 2011 |
Relation of taurine transport and brain edema in rats with simple hyperammonemia or liver failure.
Topics: Ammonia; Animals; Basal Ganglia; Body Water; Brain Edema; Cerebral Cortex; Hepatic Encephalopathy; I | 1996 |
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto | 1997 |
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto | 1997 |
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto | 1997 |
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto | 1997 |
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto | 1997 |
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto | 1997 |
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto | 1997 |
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto | 1997 |
Prevention of liver failure in parenteral nutrition-dependent children with short bowel syndrome.
Topics: Bacterial Translocation; Catheters, Indwelling; Child; Child, Preschool; Cholestasis; Clinical Proto | 1997 |
Extracellular concentrations of taurine, glutamate, and aspartate in the cerebral cortex of rats at the asymptomatic stage of thioacetamide-induced hepatic failure: modulation by ketamine anesthesia.
Topics: Anesthetics, Dissociative; Animals; Aspartic Acid; Body Water; Cerebral Cortex; Extracellular Space; | 2000 |