taurine and Innate Inflammatory Response studies

Research Excerpts

Excerpt	Relevance	Reference
"Taurine improves endothelial function in CBS-deficient homocystinuria in patients with preexisting reduced function."	9.30	Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine β-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial. ( Christians, U; Cowan, TM; Creadon-Swindell, G; Emmett, P; Ficicioglu, C; Freehauf, CL; Friederich, MW; Harrington, MJ; Henthorn, TK; Hite, M; Jiang, H; Kronquist, KE; MacLean, KN; Moreau, KL; Pena, LDM; Pyle, L; Spector, EB; Stabler, SP; Thomas, JA; Van Hove, JLK; Wempe, MF; Young, SP, 2019)
" Thus, we investigated the anti-inflammatory effect of exercise and taurine supplementation on peripheral markers of BBB, inflammation, and cognition of elderly women."	9.27	Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women. ( Chupel, MU; Filaire, E; Furtado, G; Hogervorst, E; Minuzzi, LG; Santos, ML; Teixeira, AM, 2018)
"This study was conducted to explore the beneficial role of taurine against chronic high carbohydrate diet-induced oxidative stress, endoplasmic reticulum (ER) stress and inflammation, and to understand the underlying molecular mechanisms in turbot."	8.02	Dietary taurine modulates hepatic oxidative status, ER stress and inflammation in juvenile turbot (Scophthalmus maximus L.) fed high carbohydrate diets. ( Liu, D; Mai, K; Pan, M; Wei, Z; Wu, C; Yang, M; Zhang, W; Zhang, Y, 2021)
"The protective effect of taurine against inflammation, apoptosis and oxidative stress in traumatic brain injury was investigated in the present study."	7.88	Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury. ( Li, S; Liu, H; Niu, X; Zheng, S, 2018)
" Furthermore, we assessed the therapeutic effects of taurine on ovalbumin (OVA)-induced allergic rhinitis (AR) animal models."	7.85	The potential protective role of taurine against experimental allergic inflammation. ( Jeong, HJ; Kim, HM; Nam, SY, 2017)
" Taurine protects cells from the cytotoxic effects of inflammation."	7.83	Diverse effects of taurine on vascular response and inflammation in GSH depletion model in rabbits. ( Kerry, Z; Ozgur, HH; Ozsarlak-Sozer, G; Sevin, G; Yetik-Anacak, G, 2016)
"We observed no overall association between serum taurine and stroke risk, although a protective effect was observed in never smokers, which requires further investigation."	7.83	Serum Taurine and Stroke Risk in Women: A Prospective, Nested Case-Control Study. ( Afanasyeva, Y; Chen, Y; Costa, M; Jonas, S; Koenig, KL; Wójcik, OP; Wu, F; Zeleniuch-Jacquotte, A, 2016)
"Our findings indicate that taurine treatment attenuates the infiltration of adipose tissue by macrophages and modulates the phenotype of macrophages, which suggest that taurine is a valuable food constituent with a potential to attenuate chronic inflammation in adipose tissue and improve obesity-related insulin resistance."	7.79	Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages. ( Goto, T; Hirai, S; Kawada, T; Lin, S; Murakami, S; Mutoh, C; Sakurai, T; Takahashi, N; Tani, F; Yamaguchi, Y; Yu, R, 2013)
"Taurine is reported to reduce tissue damage induced by inflammation and to protect the brain against experimental stroke."	7.78	Anti-inflammatory mechanism of taurine against ischemic stroke is related to down-regulation of PARP and NF-κB. ( Gu, Y; Sun, M; Xu, C; Zhao, Y, 2012)
" PA and Tau effectively inhibited inflammation, edema, severity of fibrosis, fibrosis extension, inflammatory cell accumulation, iNOS staining, and hydroxyproline level as well (p < 0."	7.78	The efficiency of proanthocyanidin in an experimental pulmonary fibrosis model: comparison with taurine. ( Agackiran, Y; Akyurek, N; Gul, H; Gunay, E; Gunay, S; Ide, T; Memis, L; Sirin, YS, 2012)
"Neutrophil elastase in the cystic fibrosis airways inhibits opsonophagocytosis and induces the expression of interleukin-8, a neutrophil chemoattractant."	7.73	Prolastin aerosol therapy and sputum taurine in cystic fibrosis. ( Berthiaume, Y; Cantin, AM; Cloutier, D; Martel, M, 2006)
" This study evaluated the potential usefulness of supplementation of total parenteral nutrition with a cysteine, taurine, threonine, and serine mixture (SEAS), with or without glutamine, in an experimental model of turpentine-induced acute inflammation."	7.72	Efficiency of a cysteine-taurine-threonine-serine supplemented parenteral nutrition in an experimental model of acute inflammation. ( Bérard, MP; Chaïb, S; Cynober, L; De Bandt, JP; Neveux, N; Osowska, S, 2003)
"Taurine is an intracellular free amino acid that has anti-inflammatory and antioxidant effects."	5.72	Mechanism of taurine reducing inflammation and organ injury in sepsis mice. ( Deng, S; Hao, Y; Li, R; Ma, Y; Qin, Q; Ran, C; Zhang, J; Zhang, Y; Zhu, L, 2022)
"Lung injury is a significant complication associated with cholestasis/cirrhosis."	5.72	Taurine mitigates the development of pulmonary inflammation, oxidative stress, and histopathological alterations in a rat model of bile duct ligation. ( Abdoli, N; Azarpira, N; Heidari, R; Lu, Y; Ma, Y; Manthari, RK; Mazloomi, S; Mehrabani, PS; Mingyu, Y; Mobasheri, A; Mousavifaraz, A; Nadgaran, A; Niknahad, H; Nikoozadeh, A; Ommati, MM; Rezaei, M; Sadeghian, I; Tang, Z; Xin, H; Xu, D, 2022)
" Chronic administration of taurine attenuated STZ-induced cognitive impairment."	5.46	Chronic treatment with taurine after intracerebroventricular streptozotocin injection improves cognitive dysfunction in rats by modulating oxidative stress, cholinergic functions and neuroinflammation. ( Gupta, YK; Reeta, KH; Singh, D, 2017)
"Taurine pretreatment also reduced the elevated expression levels of LPS‑induced cyclooxygenase‑2, nuclear factor κB and extracellular regulated protein kinase."	5.46	Taurine alleviates lipopolysaccharide‑induced liver injury by anti‑inflammation and antioxidants in rats. ( Li, F; Liu, Y; Wang, Y; Wu, J; Yu, H; Zhang, L, 2017)
"Maternal obesity is associated with obesity and metabolic disorders in offspring."	5.39	Effects of taurine supplementation on hepatic markers of inflammation and lipid metabolism in mothers and offspring in the setting of maternal obesity. ( Gray, C; Li, M; Reynolds, CM; Sloboda, DM; Vickers, MH, 2013)
"Taurine has been shown to protect against lung injury induced by various oxidants including ozone, nitrogen dioxide, amiodarone, and paraquat and to protect against bleomycin-induced lung injury in combination with niacin."	5.35	Protection of bleomycin-induced fibrosis and inflammation by taurine. ( Gordon, RE; Park, E; Park, SY; Schuller-Levis, G; Wang, C, 2009)
"Taurine improves endothelial function in CBS-deficient homocystinuria in patients with preexisting reduced function."	5.30	Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine β-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial. ( Christians, U; Cowan, TM; Creadon-Swindell, G; Emmett, P; Ficicioglu, C; Freehauf, CL; Friederich, MW; Harrington, MJ; Henthorn, TK; Hite, M; Jiang, H; Kronquist, KE; MacLean, KN; Moreau, KL; Pena, LDM; Pyle, L; Spector, EB; Stabler, SP; Thomas, JA; Van Hove, JLK; Wempe, MF; Young, SP, 2019)
"The practice of prolonged exercise with high intensity, as seen in triathlon training, can cause physiological imbalances that might result in muscle fatigue, muscle damage and changes in systemic inflammatory response, thus reduce the athletes' physical performance, therefore, both adequate total caloric and macronutrient intake also the use of a specific ergogenic aid, as taurine supplementation would be an alternative to prevent inflammation and muscle damage."	5.27	Effects of taurine on markers of muscle damage, inflammatory response and physical performance in triathletes. ( Carvalho, FG; da Silva, AS; Freitas, EC; Galan, BS; Gobbi, RB; Kalva-Filho, CA; Papoti, M; Santos, PC, 2018)
" Thus, we investigated the anti-inflammatory effect of exercise and taurine supplementation on peripheral markers of BBB, inflammation, and cognition of elderly women."	5.27	Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women. ( Chupel, MU; Filaire, E; Furtado, G; Hogervorst, E; Minuzzi, LG; Santos, ML; Teixeira, AM, 2018)
"Amelioration of both oxidative and inflammation status after cholesterol lowering treatment in CKD might be mediated by restoration of antioxidant taurine concentrations during therapy (from 51."	5.20	Impact of cholesterol lowering treatment on plasma kynurenine and tryptophan concentrations in chronic kidney disease: relationship with oxidative stress improvement. ( Carru, C; Mangoni, AA; Sanna, M; Satta, AE; Sotgia, S; Zinellu, A, 2015)
"The purpose of the present study was to investigate the effects of taurine supplementation on muscle performance, oxidative stress, and inflammation response after eccentric exercise (EE) in males."	5.19	Effects of taurine supplementation following eccentric exercise in young adults. ( Bom, KF; Cassiano, W; da Luz, G; da Rosa, GL; da Silva, LA; De Souza, CT; Mariano, I; Petronilho, F; Pinho, RA; Pozzi, B; Tromm, CB; Tuon, T; Vuolo, F, 2014)
"Taurine chloramine (TauCl) is generated at the site of inflammation as a result of reaction of taurine with hypochlorous acid (HOCl), the product of myeloperoxidase-halide system of neutrophils."	4.87	[Taurine chloramine and its potential therapeutical application]. ( Marcinkiewicz, J; Walczewska, M, 2011)
" It plays a key role in the metabolic pathways involving methionine, taurine and glutathione (GSH), and may help fight chronic inflammation by boosting antioxidant status."	4.87	Clinical and nutritional benefits of cysteine-enriched protein supplements. ( Hardy, G; McPherson, RA, 2011)
"On the 3rd day, taurine and apocynin prevented inflammation, the effects of taurine in the zone of stasis in the early period (7th day) are more pronounced, the effect of apocynin on antioxidant enzymes is more pronounced."	4.12	Effects of taurine and apocynin on the zone of stasis. ( Abbas Ali Noma, S; Fırat, C; Öcük, Ö; Özhan, O; Parlakpınar, H; Ulu, A; Vardı, N; Yıldız, A, 2022)
"The aim of the present study is to examine the potential effect of dexamethasone (DEX) and taurine (TAU) on endoplasmic reticular stress (ERS) and inflammation."	4.12	Synergism Between Taurine and Dexamethasone in Anti-inflammatory Response in LPS-Activated Macrophages. ( Do, CH; Lee, DH, 2022)
"This study was conducted to explore the beneficial role of taurine against chronic high carbohydrate diet-induced oxidative stress, endoplasmic reticulum (ER) stress and inflammation, and to understand the underlying molecular mechanisms in turbot."	4.02	Dietary taurine modulates hepatic oxidative status, ER stress and inflammation in juvenile turbot (Scophthalmus maximus L.) fed high carbohydrate diets. ( Liu, D; Mai, K; Pan, M; Wei, Z; Wu, C; Yang, M; Zhang, W; Zhang, Y, 2021)
" The present study assessed the ability of taurine (TAU) to alleviate or prevent AMK-induced nephrotoxicity if co-administrated with AMK focusing on inflammation, apoptosis, and fibrosis."	4.02	The nephroprotective properties of taurine-amikacin treatment in rats are mediated through HSP25 and TLR-4 regulation. ( Azmy, A; El-Amir, A; Madbouly, N; Salama, A, 2021)
"The protective effect of taurine against inflammation, apoptosis and oxidative stress in traumatic brain injury was investigated in the present study."	3.88	Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury. ( Li, S; Liu, H; Niu, X; Zheng, S, 2018)
" Furthermore, we assessed the therapeutic effects of taurine on ovalbumin (OVA)-induced allergic rhinitis (AR) animal models."	3.85	The potential protective role of taurine against experimental allergic inflammation. ( Jeong, HJ; Kim, HM; Nam, SY, 2017)
" Importantly, angiotensin II (AngII), independently of its vasoconstrictor action, causes β-cell inflammation and dysfunction, which may be an early step in the development of type 2 diabetes."	3.85	Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response. ( Chan, SMH; Herbert, TP; Ku, JM; Lau, YS; Miller, AA; Potocnik, S; Woodman, OL; Ye, JM, 2017)
" Taurine protects cells from the cytotoxic effects of inflammation."	3.83	Diverse effects of taurine on vascular response and inflammation in GSH depletion model in rabbits. ( Kerry, Z; Ozgur, HH; Ozsarlak-Sozer, G; Sevin, G; Yetik-Anacak, G, 2016)
"We observed no overall association between serum taurine and stroke risk, although a protective effect was observed in never smokers, which requires further investigation."	3.83	Serum Taurine and Stroke Risk in Women: A Prospective, Nested Case-Control Study. ( Afanasyeva, Y; Chen, Y; Costa, M; Jonas, S; Koenig, KL; Wójcik, OP; Wu, F; Zeleniuch-Jacquotte, A, 2016)
"At the sites of inflammation, hypohalous acids, such as hypochlorous acid and hypobromous acid (HOBr), are produced by myeloperoxidase."	3.81	Specific role of taurine in the 8-brominated-2'-deoxyguanosine formation. ( Asahi, T; Kato, Y; Nakamura, Y; Osawa, T, 2015)
"Our findings indicate that taurine treatment attenuates the infiltration of adipose tissue by macrophages and modulates the phenotype of macrophages, which suggest that taurine is a valuable food constituent with a potential to attenuate chronic inflammation in adipose tissue and improve obesity-related insulin resistance."	3.79	Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages. ( Goto, T; Hirai, S; Kawada, T; Lin, S; Murakami, S; Mutoh, C; Sakurai, T; Takahashi, N; Tani, F; Yamaguchi, Y; Yu, R, 2013)
"Taurine is reported to reduce tissue damage induced by inflammation and to protect the brain against experimental stroke."	3.78	Anti-inflammatory mechanism of taurine against ischemic stroke is related to down-regulation of PARP and NF-κB. ( Gu, Y; Sun, M; Xu, C; Zhao, Y, 2012)
"This pilot study aimed to determine the efficacy of acamprosate (N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS)."	3.78	Acamprosate modulates experimental autoimmune encephalomyelitis. ( Cesario, A; Leung, YK; Munschauer, FE; Pankewycz, O; Rittenhouse-Olson, K; Sobel, RA; Sternberg, DS; Sternberg, Z; Whitcomb, T; Zhu, B, 2012)
" PA and Tau effectively inhibited inflammation, edema, severity of fibrosis, fibrosis extension, inflammatory cell accumulation, iNOS staining, and hydroxyproline level as well (p < 0."	3.78	The efficiency of proanthocyanidin in an experimental pulmonary fibrosis model: comparison with taurine. ( Agackiran, Y; Akyurek, N; Gul, H; Gunay, E; Gunay, S; Ide, T; Memis, L; Sirin, YS, 2012)
"Our results indicate that taurine has protective effects on hyperhomocysteinemia-induced toxicity by decreasing oxidative and nitrosative stresses, apoptosis, and necrosis in the liver."	3.75	Oxidative and nitrosative stress and apoptosis in the liver of rats fed on high methionine diet: protective effect of taurine. ( Doğru-Abbasoğlu, S; Giriş, M; Olgaç, V; Unlüçerçi, Y; Uysal, M; Yalçinkaya, S, 2009)
"Neutrophil elastase in the cystic fibrosis airways inhibits opsonophagocytosis and induces the expression of interleukin-8, a neutrophil chemoattractant."	3.73	Prolastin aerosol therapy and sputum taurine in cystic fibrosis. ( Berthiaume, Y; Cantin, AM; Cloutier, D; Martel, M, 2006)
"In this study, in an animal model of zymosan-induced peritonitis we have tested anti-inflammatory properties of Taurolidine (TRD), a synthetic derivative of taurine."	3.73	Anti-inflammatory effects of taurine derivatives (taurine chloramine, taurine bromamine, and taurolidine) are mediated by different mechanisms. ( Biedroń, R; Bobek, M; Kontny, E; Kurnyta, M; Marcinkiewicz, J; Maśliński, W, 2006)
" This study evaluated the potential usefulness of supplementation of total parenteral nutrition with a cysteine, taurine, threonine, and serine mixture (SEAS), with or without glutamine, in an experimental model of turpentine-induced acute inflammation."	3.72	Efficiency of a cysteine-taurine-threonine-serine supplemented parenteral nutrition in an experimental model of acute inflammation. ( Bérard, MP; Chaïb, S; Cynober, L; De Bandt, JP; Neveux, N; Osowska, S, 2003)
"The effect of in-vivo administration of N-2-hydroxyethylpiperazine-N'-2- ethane sulphonic acid (HEPES) and taurine on rat paw oedema and reactive oxidant production was examined."	3.69	Effects of in-vivo administration of taurine and HEPES on the inflammatory response in rats. ( Bloomfield, FJ; Mahon, TM; Nowlan, P; Stapleton, PP, 1994)
"Combined treatment with taurine and niacin suppressed BL-induced inflammation and almost completely abrogated pulmonary fibrosis in hamsters."	3.68	Abatement of bleomycin-induced increases in vascular permeability, inflammatory cell infiltration, and fibrotic lesions in hamster lungs by combined treatment with taurine and niacin. ( Giri, SN; Hyde, DM; Wang, Q, 1992)
"Peri-operative inflammation has been extensively highlighted in cancer patients as detrimental."	2.87	RandomiSed clinical trial assessing Use of an anti-inflammatoRy aGent in attenUating peri-operatiVe inflAmmatioN in non-meTastatic colon cancer - the S.U.R.G.U.V.A.N.T. trial. ( Foley, N; Jinih, M; Neary, PM; O'Connell, E; O'Leary, DP; Pfirrmann, RW; Redmond, HP; Wang, JH, 2018)
" Non-linear relationship between variables and effect size was performed using dose-response and time-response analyses."	2.82	Profiling inflammatory and oxidative stress biomarkers following taurine supplementation: a systematic review and dose-response meta-analysis of controlled trials. ( Faghfouri, AH; Faghfuri, E; Fathollahi, P; Ostadrahimi, A; Papi, S; Seyyed Shoura, SM; Shadbad, MA, 2022)
"Taurine has become a popular supplement among athletes attempting to improve performance."	2.72	Taurine in sports and exercise. ( Doyle, JA; Kurtz, JA; Otis, JS; VanDusseldorp, TA, 2021)
"Hyperlipidemia, an independent risk factor for atherosclerosis, is regarded as a lipid metabolism disorder associated with elevated plasma triglyceride and/or cholesterol."	2.72	The molecular targets of taurine confer anti-hyperlipidemic effects. ( Dong, Y; Gao, J; Li, X; Liu, Y; Tao, J, 2021)
"Taurine is a non-protein amino acid that is expressed in the majority of animal tissues."	2.66	The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease. ( Abraham, JR; Apostolopoulos, V; Gadanec, LK; McSweeney, KR; Qaradakhi, T; Zulli, A, 2020)
"Glycine has been well characterized in spinal cord as an inhibitory neurotransmitter which activates a glycine-gated chloride channel (GlyR) expressed in postsynaptic membranes."	2.40	Glycine: a new anti-inflammatory immunonutrient. ( Bradford, B; Enomoto, N; Ikejema, K; Rose, ML; Rusyn, I; Schemmer, P; Seabra, V; Stacklewitz, RF; Thurman, RG; Wheeler, MD; Yin, M; Zhong, Z, 1999)
"Lung injury is a significant complication associated with cholestasis/cirrhosis."	1.72	Taurine mitigates the development of pulmonary inflammation, oxidative stress, and histopathological alterations in a rat model of bile duct ligation. ( Abdoli, N; Azarpira, N; Heidari, R; Lu, Y; Ma, Y; Manthari, RK; Mazloomi, S; Mehrabani, PS; Mingyu, Y; Mobasheri, A; Mousavifaraz, A; Nadgaran, A; Niknahad, H; Nikoozadeh, A; Ommati, MM; Rezaei, M; Sadeghian, I; Tang, Z; Xin, H; Xu, D, 2022)
"Taurine was identified as an important metabolite may modulate human cervical smooth muscle cells."	1.72	Metabonomics profile analysis in inflammation-induced preterm birth and the potential role of metabolites in regulating premature cervical ripening. ( Bian, Z; Gu, Z; Guo, X; Li, B; Qiu, J; Yan, Y; Zhang, R; Zhang, Z, 2022)
"Taurine is an intracellular free amino acid that has anti-inflammatory and antioxidant effects."	1.72	Mechanism of taurine reducing inflammation and organ injury in sepsis mice. ( Deng, S; Hao, Y; Li, R; Ma, Y; Qin, Q; Ran, C; Zhang, J; Zhang, Y; Zhu, L, 2022)
"Taurine (Tau) is a kind of semi-essential β amino acid, and beneficial for β cell function."	1.51	Inorganic arsenic induces pyroptosis and pancreatic β cells dysfunction through stimulating the IRE1α/TNF-α pathway and protective effect of taurine. ( Gao, N; Jia, X; Jiang, L; Liu, S; Liu, X; Pei, P; Qiu, T; Sun, X; Tao, Y; Wang, N; Wang, Z; Wei, S; Yang, G; Yang, L; Yao, X, 2019)
"Inflammation is a key contributor to the pathology of nonalcoholic fatty liver disease (NAFLD), including NASH."	1.48	Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway. ( Bai, J; Gao, N; Jiang, L; Liu, X; Pei, P; Qi, S; Qiu, T; Sun, X; Wang, Z; Wei, S; Yan, R; Yang, G; Yang, L; Yao, X, 2018)
"Osteoarthritis is a type of joint disease that results from the breakdown of joint cartilage and underlying bone and is believed to be caused by mechanical stress on the joint and low-grade inflammatory processes."	1.48	Acamprosate Protects Against Adjuvant-Induced Arthritis in Rats via Blocking the ERK/MAPK and NF-κB Signaling Pathway. ( Jin, R; Pan, J; Shen, M; Wu, R; Xu, S, 2018)
"Taurine pretreatment also reduced the elevated expression levels of LPS‑induced cyclooxygenase‑2, nuclear factor κB and extracellular regulated protein kinase."	1.46	Taurine alleviates lipopolysaccharide‑induced liver injury by anti‑inflammation and antioxidants in rats. ( Li, F; Liu, Y; Wang, Y; Wu, J; Yu, H; Zhang, L, 2017)
" Chronic administration of taurine attenuated STZ-induced cognitive impairment."	1.46	Chronic treatment with taurine after intracerebroventricular streptozotocin injection improves cognitive dysfunction in rats by modulating oxidative stress, cholinergic functions and neuroinflammation. ( Gupta, YK; Reeta, KH; Singh, D, 2017)
"Maternal obesity is associated with obesity and metabolic disorders in offspring."	1.39	Effects of taurine supplementation on hepatic markers of inflammation and lipid metabolism in mothers and offspring in the setting of maternal obesity. ( Gray, C; Li, M; Reynolds, CM; Sloboda, DM; Vickers, MH, 2013)
"Taurine was without effect."	1.37	Taurine chloramine inhibits NO and TNF-α production in zymosan plus interferon-γ activated RAW 264.7 cells. ( Cho, IS; Kim, BS; Levis, W; Park, E; Park, SY; Schuller-Levis, G, 2011)
"Taurine was injected intraperitoneally at doses of 25, 80, 250, and 800 mg/kg within 30 min after SCI."	1.36	Taurine reduces inflammatory responses after spinal cord injury. ( Gupta, RC; Hara, M; Nakajima, Y; Osuka, K; Seki, Y; Takayasu, M; Wakabayashi, T, 2010)
"Taurine has been shown to protect against lung injury induced by various oxidants including ozone, nitrogen dioxide, amiodarone, and paraquat and to protect against bleomycin-induced lung injury in combination with niacin."	1.35	Protection of bleomycin-induced fibrosis and inflammation by taurine. ( Gordon, RE; Park, E; Park, SY; Schuller-Levis, G; Wang, C, 2009)

Research

Studies (118)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Changes in Serum Concentration of Inflammatory Biomarkers (TNF-alpha)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (1.69)	18.7374
1990's	9 (7.63)	18.2507
2000's	21 (17.80)	29.6817
2010's	59 (50.00)	24.3611
2020's	27 (22.88)	2.80

Authors	Studies
Saunders, MJ	1
Edwards, BS	1
Zhu, J	1
Sklar, LA	1
Graves, SW	1
Faghfouri, AH	1
Seyyed Shoura, SM	1
Fathollahi, P	1
Shadbad, MA	1
Papi, S	1
Ostadrahimi, A	1
Faghfuri, E	1
Li, M	2
Wang, Z	3
Qiu, Y	1
Fu, S	1
Xu, Y	1
Han, X	1
Phouthapane, V	1
Miao, J	2
Zhuang, Z	1
Li, N	2
Wang, J	2
Yang, R	1
Wang, W	2
Liu, Z	1
Huang, T	1
Öcük, Ö	1
Fırat, C	1
Yıldız, A	1
Vardı, N	1
Ulu, A	1
Abbas Ali Noma, S	1
Parlakpınar, H	1
Özhan, O	1
Ma, Y	2
Zhang, Y	3
Li, R	1
Deng, S	1
Qin, Q	1
Ran, C	1
Hao, Y	1
Zhang, J	4
Zhu, L	1
Do, CH	1
Lee, DH	1
Kim, HJ	1
Kang, IS	1
Kim, C	7
Shi, Y	1
Zhong, L	1
Fan, Y	1
Dai, J	1
Zhong, H	1
Fu, G	1
Hu, Y	1
Yan, Y	1
Gu, Z	1
Li, B	1
Guo, X	1
Zhang, Z	1
Zhang, R	1
Bian, Z	1
Qiu, J	1
Ommati, MM	1
Mobasheri, A	1
Xu, D	1
Tang, Z	2
Manthari, RK	1
Abdoli, N	1
Azarpira, N	1
Lu, Y	2
Sadeghian, I	1
Mousavifaraz, A	1
Nadgaran, A	1
Nikoozadeh, A	1
Mazloomi, S	1
Mehrabani, PS	1
Rezaei, M	1
Xin, H	1
Mingyu, Y	1
Niknahad, H	1
Heidari, R	1
Ji, X	1
Zhang, F	1
Zhou, F	1
Wu, Y	1
Wu, D	1
Reikvam, H	1
Bruserud, Ø	1
Hatfield, KJ	1
Busı, MC	1
Yigitaslan, S	1
Kaltus, Z	1
Harmancı, N	1
Eroglu, E	1
Ozatık, O	1
Kaya, C	1
Martins, N	1
Magalhães, R	1
Castro, C	1
Couto, A	1
Díaz-Rosales, P	1
Oliva-Teles, A	1
Peres, H	1
Lee, H	1
Lee, DS	1
Chang, KJ	1
Kim, SH	3
Cheong, SH	1
Zang, L	1
Song, Y	1
Yu, F	1
Liu, X	3
He, Y	1
Yang, Z	1
Li, J	2
Li, E	1
Jiménez Hernández, M	1
Soriano, A	2
Filella, X	1
Calvo, M	1
Coll, E	1
Rebled, JM	1
Poch, E	1
Graterol, F	1
Compte, MT	1
Maduell, F	2
Fontsere, N	2
Baliou, S	1
Kyriakopoulos, AM	1
Spandidos, DA	1
Zoumpourlis, V	1
Han, H	1
Chen, Y	2
Shen, M	2
Yan, E	1
Wei, C	1
Yu, C	1
Zhang, L	3
Wang, T	1
Qaradakhi, T	1
Gadanec, LK	1
McSweeney, KR	1
Abraham, JR	1
Apostolopoulos, V	1
Zulli, A	1
Barbiera, A	1
Sorrentino, S	1
Lepore, E	1
Carfì, A	1
Sica, G	1
Dobrowolny, G	1
Scicchitano, BM	1
Wei, Z	1
Yang, M	1
Liu, D	2
Pan, M	1
Wu, C	1
Zhang, W	1
Mai, K	1
Iwegbulem, O	1
Pfirrmann, RW	2
Redmond, HP	3
Dong, Y	1
Li, X	1
Liu, Y	2
Gao, J	1
Tao, J	1
Kurtz, JA	1
VanDusseldorp, TA	1
Doyle, JA	1
Otis, JS	1
Lee, CC	1
Chen, WT	1
Chen, SY	1
Lee, TM	1
Madbouly, N	1
Azmy, A	1
Salama, A	1
El-Amir, A	1
López-Cano, JJ	1
González-Cela-Casamayor, MA	1
Andrés-Guerrero, V	1
Herrero-Vanrell, R	1
Benítez-Del-Castillo, JM	1
Molina-Martínez, IT	1
Adedara, IA	1
Olabiyi, BF	1
Ojuade, TD	1
Idris, UF	1
Onibiyo, EM	1
Farombi, EO	1
Nam, SY	1
Kim, HM	1
Jeong, HJ	1
Galan, BS	1
Carvalho, FG	1
Santos, PC	1
Gobbi, RB	1
Kalva-Filho, CA	1
Papoti, M	1
da Silva, AS	1
Freitas, EC	1
Li, F	1
Wu, J	1
Wang, Y	2
Yu, H	2
Chan, SMH	1
Lau, YS	1
Miller, AA	1
Ku, JM	1
Potocnik, S	1
Ye, JM	1
Woodman, OL	1
Herbert, TP	1
Chupel, MU	1
Minuzzi, LG	1
Furtado, G	1
Santos, ML	1
Hogervorst, E	1
Filaire, E	1
Teixeira, AM	1
Kim, W	2
Jang, JH	1
Kim, K	2
Suh, YG	2
Joe, Y	2
Chung, HT	2
Cha, YN	3
Surh, YJ	2
Pan, J	1
Jin, R	1
Wu, R	1
Xu, S	1
Zhao, W	1
Jia, L	1
Yang, HJ	1
Xue, X	1
Xu, WX	1
Cai, JQ	1
Guo, RJ	1
Cao, CC	1
Neary, PM	1
Jinih, M	1
O'Connell, E	1
Foley, N	1
Wang, JH	1
O'Leary, DP	1
Xiao, M	1
Mi, Y	1
Liu, L	1
Lv, C	1
Zeng, W	1
Zhang, C	1
Niu, X	1
Zheng, S	1
Liu, H	1
Li, S	1
Qiu, T	2
Pei, P	2
Yao, X	2
Jiang, L	2
Wei, S	2
Bai, J	1
Yang, G	2
Gao, N	2
Yang, L	2
Qi, S	1
Yan, R	1
Sun, X	2
Ghosh, S	1
Chowdhury, S	1
Das, AK	1
Sil, PC	2
Wang, N	1
Liu, S	1
Jia, X	1
Tao, Y	1
Zhou, J	1
Yao, N	1
Wang, S	2
An, D	1
Cao, K	1
Wei, J	1
Zhao, D	1
Wang, L	1
Chen, X	1
Chiquita, S	1
Ribeiro, M	1
Castelhano, J	1
Oliveira, F	1
Sereno, J	1
Batista, M	1
Abrunhosa, A	1
Rodrigues-Neves, AC	1
Carecho, R	1
Baptista, F	1
Gomes, C	1
Moreira, PI	1
Ambrósio, AF	1
Castelo-Branco, M	1
Van Hove, JLK	1
Freehauf, CL	1
Ficicioglu, C	1
Pena, LDM	1
Moreau, KL	1
Henthorn, TK	1
Christians, U	1
Jiang, H	2
Cowan, TM	1
Young, SP	1
Hite, M	1
Friederich, MW	1
Stabler, SP	1
Spector, EB	1
Kronquist, KE	1
Thomas, JA	1
Emmett, P	1
Harrington, MJ	1
Pyle, L	1
Creadon-Swindell, G	1
Wempe, MF	1
MacLean, KN	2
Chen, DQ	1
Cao, G	1
Chen, H	1
Argyopoulos, CP	1
Su, W	1
Chen, L	1
Samuels, DC	1
Zhuang, S	1
Bayliss, GP	1
Zhao, S	1
Yu, XY	1
Vaziri, ND	1
Wang, M	1
Mao, JR	1
Ma, SX	1
Zhao, J	1
Shang, YQ	1
Kang, H	1
Ye, F	1
Cheng, XH	1
Li, XR	1
Meng, MX	1
Guo, Y	1
Zhao, YY	1
Manna, P	1
Das, J	1
Spreafico, A	1
Millucci, L	1
Ghezzi, L	1
Geminiani, M	1
Braconi, D	1
Amato, L	1
Chellini, F	1
Frediani, B	1
Moretti, E	1
Collodel, G	1
Bernardini, G	1
Santucci, A	1
Lin, S	1
Hirai, S	1
Yamaguchi, Y	1
Goto, T	1
Takahashi, N	1
Tani, F	1
Mutoh, C	1
Sakurai, T	1
Murakami, S	1
Yu, R	1
Kawada, T	1
Dort, J	1
Leblanc, N	1
Maltais-Giguère, J	1
Liaset, B	1
Côté, CH	1
Jacques, H	1
Reynolds, CM	1
Sloboda, DM	1
Gray, C	1
Vickers, MH	1
Kim, KS	1
Ji, HI	1
Chung, H	1
Lee, SH	1
Lee, YA	1
Yang, HI	1
Yoo, MC	1
Hong, SJ	1
Velloso, MS	1
Otoni, A	1
de Paula Sabino, A	1
de Castro, WV	1
Pinto, SW	1
Marinho, MA	1
Rios, DR	1
da Silva, LA	1
Tromm, CB	1
Bom, KF	1
Mariano, I	1
Pozzi, B	1
da Rosa, GL	1
Tuon, T	1
da Luz, G	1
Vuolo, F	1
Petronilho, F	1
Cassiano, W	1
De Souza, CT	1
Pinho, RA	1
Latchoumycandane, C	1
Nagy, LE	1
McIntyre, TM	1
Su, Y	1
Fan, W	1
Ma, Z	1
Wen, X	1
Wu, Q	1
Huang, H	1
Cardozo, C	1
Donate, J	1
Muros, M	1
Pons, M	1
Mensa, J	1
Campistol, JM	1
Navarro-González, JF	1
Alhouayek, M	1
Bottemanne, P	1
Subramanian, KV	1
Lambert, DM	1
Makriyannis, A	1
Cani, PD	1
Muccioli, GG	1
Zinellu, A	1
Sotgia, S	1
Mangoni, AA	1
Sanna, M	1
Satta, AE	1
Carru, C	1
Kim, HU	1
Lee, HN	1
Jang, J	1
Jin, HO	1
Lee, JK	1
Walczewska, M	3
Ciszek-Lenda, M	1
Surmiak, M	1
Kozlowska, A	1
Jozefowski, S	1
Marcinkiewicz, J	9
Kato, T	1
Okita, S	1
Tsunekawa, M	1
Ma, N	1
Lin, CJ	1
Chiu, CC	1
Chen, YC	1
Chen, ML	1
Hsu, TC	1
Tzang, BS	1
Asahi, T	1
Nakamura, Y	1
Kato, Y	1
Osawa, T	1
Wu, F	1
Koenig, KL	1
Zeleniuch-Jacquotte, A	1
Jonas, S	1
Afanasyeva, Y	1
Wójcik, OP	1
Costa, M	1
Ozsarlak-Sozer, G	1
Sevin, G	1
Ozgur, HH	1
Yetik-Anacak, G	1
Kerry, Z	1
Reeta, KH	1
Singh, D	1
Gupta, YK	1
Pupure, J	1
Isajevs, S	1
Gordjushina, V	1
Taivans, I	1
Rumaks, J	1
Svirskis, S	1
Kratovska, A	1
Dzirkale, Z	1
Pilipenko, J	1
Duburs, G	1
Klusa, V	1
Yalçinkaya, S	1
Unlüçerçi, Y	1
Giriş, M	1
Olgaç, V	1
Doğru-Abbasoğlu, S	1
Uysal, M	1
Olszanecki, R	2
Bobek, M	3
Biedroń, R	3

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease[NCT05719714]	Phase 1/Phase 2	60 participants (Anticipated)	Interventional	2023-11-01	Recruiting
Taurine as a Possible Anti-aging Therapy? A Controlled Clinical Trial on Taurine Antioxidant Activity in Women Aged 55 to 70 Years[NCT05149716]		24 participants (Actual)	Interventional	2020-01-13	Completed
Evaluation of the Capability of a Glycine Oral Supplement for Diminishing Bronchial Inflammation in Children With Cystic Fibrosis[NCT01417481]	Phase 2	13 participants (Actual)	Interventional	2012-03-31	Terminated (stopped due to Some of the researchers finished their participation in the study.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentages were log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Changes in Sputum Concentration of Inflammatory Biomarkers (G-CSF)

Intervention	log (percent change) (Mean)
Glycine	-0.3908
Placebo	0.2035

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentage change was log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Changes in Sputum Concentration of Inflammatory Biomarkers (IL-6)

Intervention	log (percent change) (Mean)
Glycine	-0.0819
Placebo	0.1668

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentage change was log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Changes in Clinical Data Scores (Other Than Sputum Production, Dyspnea and Global Symptoms)

Intervention	log (percent change) (Mean)
Glycine	-0.00007
Placebo	0.1739

"To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]).~Each respiratory symptom (Cough severity, Sputum features, Appetite, Dyspnea, and Energy perception) was evaluated in a 5-options Likert scale, ranging from 1 (better) to 5 (worse). The total score was computed by the simple sum of the five symptoms." (NCT01417481)
Timeframe: 8 weeks

Changes in FEV1, FEF25, and FEFmax

Intervention	Percentage of baseline (Mean)
	Cough questionnaire score	Appetite questionnaire score	Energy questionnaire score	Body weight	Height	Heart rate	Respiratory rate	Temperature
Glycine	81.1	89.1	84.6	101.6	100.5	103.5	94.8	100.0
Placebo	89.1	132.1	111.5	103.6	100.5	98.1	109.0	100.1

Changes in Other Spirometric Variables

Intervention	Percentage of baseline (Mean)
	Forced expiratory volume at first second (FEV1)	Forced expiratory flow at 25%FVC (FEF25)	Maximal forced expiratory flow (FEFmax, PEFR)
Glycine	109.7	133.9	115.3
Placebo	91.4	83.3	91.2

Changes in Pulse Oximetry, FEV1/FVC, and FEF50.

Intervention	Percentage of baseline (Mean)
	Forced vital capacity (FVC)	Forced expiratory flow at 75%FVC (FEF75)
Glycine	104.1	111.8
Placebo	100.6	108.9

Changes in Score for Sputum Production, Dyspnea and Global Symptoms

Intervention	Percentage of baseline (Mean)
	Peripheral oxygen saturation (SpO2)	FEV1/FVC	Forced expiratory flow at 50%FVC (FEF50)
Glycine	105.2	105.2	115.5
Placebo	98.9	94.9	93.1

"To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]).~In the symptoms questionnaire, each respiratory symptom (Cough severity, Sputum features, Appetite, Dyspnea, and Energy perception) was evaluated in a 5-options Likert scale, ranging from 1 (better) to 5 (worse). The total score was computed by the simple sum of the five symptoms." (NCT01417481)
Timeframe: 8 weeks

Changes in Serum Concentration of Inflammatory Biomarkers (Other Than TNF-alpha)

Intervention	Percentage of baseline (Mean)
	Sputum questionnaire score	Dyspnea questionnaire score	Total questionnaire score
Glycine	82.0	75.6	77.7
Placebo	102.6	103.8	98.7

Changes in Sputum Concentration of Inflammatory Biomarkers (Other Than IL-6 and G-CSF)

Intervention	log (percent change) (Mean)
	Myeloperoxidase	IL-1	IL-4	IL-6	IL-7	IL-8	IL-12	IL-13	G-CSF	IFN-gamma	MCP-1	MIP-1beta
Glycine	-0.4361	-0.1635	0.2964	0.0085	0.0356	-0.1466	0.3203	-0.0561	-0.0776	0.3272	-0.0836	0.0330
Placebo	-0.2906	-0.0352	0.1470	0.2255	0.0819	-0.2364	0.2603	0.1953	0.2272	0.3639	0.0472	-0.0608

To correct for the baseline variability, all measurements were expressed as percentage of baseline (value at week 8 with respect to baseline value [beginning of the glycine or placebo period, respectively]). Then, percentage change was log-transformed to adjust to a normal distribution. (NCT01417481)
Timeframe: 8 weeks

Intervention	log (percent change) (Mean)
	Myeloperoxidase	IL-1	IL-2	IL-4	IL-5	IL-7	IL-8	IL-10	IL-12	IL-13	IL-17	IFN-gamma	MCP-1	MIP-1beta	TNF-alpha	GM-CSF
Glycine	0.1294	-0.0918	0.0233	-0.0161	0.2498	0.0611	-0.0824	0.0549	0.1675	0.1630	0.0680	0.0248	0.0042	-0.0303	0.0412	-0.0538
Placebo	0.0669	-0.0102	-0.0274	0.0522	0.1304	0.1387	0.0542	0.0074	0.0677	0.0953	0.1140	0.0649	0.2608	0.0977	0.1568	-0.0822

Article	Year
Profiling inflammatory and oxidative stress biomarkers following taurine supplementation: a systematic review and dose-response meta-analysis of controlled trials. European journal of clinical nutrition, 2022, Volume: 76, Issue:5 Topics: Biomarkers; C-Reactive Protein; Dietary Supplements; Humans; Inflammation; Interleukin-6; Oxidative	2022
Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review). International journal of oncology, 2020, Volume: 57, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Proliferation; Disease Models, Animal	2020
The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease. Nutrients, 2020, Sep-17, Volume: 12, Issue:9 Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus; Humans; Inflammation; Obesity; Taurine	2020
The molecular targets of taurine confer anti-hyperlipidemic effects. Life sciences, 2021, Aug-01, Volume: 278 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Autophagy; Cholesterol; Cholesterol 7-alpha-Hydroxy	2021
Taurine in sports and exercise. Journal of the International Society of Sports Nutrition, 2021, May-26, Volume: 18, Issue:1 Topics: Athletic Performance; Blood Glucose; Body Temperature Regulation; Calcium; Dietary Supplements; Ener	2021
Role of sulfur containing amino acids as an adjuvant therapy in the prevention of diabetes and its associated complications. Current diabetes reviews, 2013, Volume: 9, Issue:3 Topics: 3T3-L1 Cells; Amino Acids, Sulfur; Animals; Blood Glucose; Cells, Cultured; Cysteine; Diabetes Melli	2013
Taurine chloramine produced from taurine under inflammation provides anti-inflammatory and cytoprotective effects. Amino acids, 2014, Volume: 46, Issue:1 Topics: Animals; Antioxidants; Apoptosis; Chronic Disease; Cytoprotection; Humans; Inflammation; Inflammatio	2014
Peritoneal dialysis and inflammation. Clinica chimica acta; international journal of clinical chemistry, 2014, Mar-20, Volume: 430 Topics: Dialysis Solutions; Glucans; Glucose; Humans; Hydrogen-Ion Concentration; Icodextrin; Inflammation;	2014
Taurine bromamine (TauBr)--its role in immunity and new perspectives for clinical use. Journal of biomedical science, 2010, Aug-24, Volume: 17 Suppl 1 Topics: Acne Vulgaris; Anti-Infective Agents; Anti-Inflammatory Agents; Clinical Trials as Topic; Eosinophil	2010
Clinical and nutritional benefits of cysteine-enriched protein supplements. Current opinion in clinical nutrition and metabolic care, 2011, Volume: 14, Issue:6 Topics: Antioxidants; Cysteine; Dietary Supplements; Functional Food; Glutathione; Humans; Inflammation; Ker	2011
[Taurine chloramine and its potential therapeutical application]. Przeglad lekarski, 2011, Volume: 68, Issue:6 Topics: Animals; Humans; Inflammation; Inflammation Mediators; Taurine	2011
Taurine and inflammatory diseases. Amino acids, 2014, Volume: 46, Issue:1 Topics: Animals; Anti-Infective Agents; Apoptosis; Arthritis, Rheumatoid; Bile Acids and Salts; Calcium; Hum	2014
The effects of sulfur amino acid intake on immune function in humans. The Journal of nutrition, 2006, Volume: 136, Issue:6 Suppl Topics: Amino Acids, Sulfur; Animals; Diet; Dose-Response Relationship, Drug; Glutathione; Homocysteine; Hum	2006
Taurine and inflammation--a new approach to an old problem? Journal of leukocyte biology, 1997, Volume: 61, Issue:2 Topics: Animals; Humans; Inflammation; Taurine	1997
Glycine: a new anti-inflammatory immunonutrient. Cellular and molecular life sciences : CMLS, 1999, Nov-30, Volume: 56, Issue:9-10 Topics: Alcohols; Animals; Anti-Inflammatory Agents; Calcium Channels, L-Type; Chloride Channels; Cyclospori	1999

Article	Year
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. Current protocols in cytometry, 2010, Volume: Chapter 13 Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr	2010
Taurine protects blood-milk barrier integrity via limiting inflammatory response in Streptococcus uberis infections. International immunopharmacology, 2021, Volume: 101, Issue:Pt B Topics: Animals; Female; Inflammation; Mastitis; Mice; Mice, Inbred C57BL; Milk; Random Allocation; Specific	2021
GWAS-associated bacteria and their metabolites appear to be causally related to the development of inflammatory bowel disease. European journal of clinical nutrition, 2022, Volume: 76, Issue:7 Topics: Bacteria; Betaine; Colitis, Ulcerative; Crohn Disease; Genome-Wide Association Study; Humans; Inflam	2022
Effects of taurine and apocynin on the zone of stasis. Burns : journal of the International Society for Burn Injuries, 2022, Volume: 48, Issue:8 Topics: Animals; Antioxidants; Burns; Disease Models, Animal; Inflammation; Rats; Rats, Sprague-Dawley; Taur	2022
Mechanism of taurine reducing inflammation and organ injury in sepsis mice. Cellular immunology, 2022, Volume: 375 Topics: Animals; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Neutrophils; Sepsis; Taurine;	2022
Synergism Between Taurine and Dexamethasone in Anti-inflammatory Response in LPS-Activated Macrophages. Advances in experimental medicine and biology, 2022, Volume: 1370 Topics: Anti-Inflammatory Agents; Cytokines; Dexamethasone; Humans; Inflammation; Lipopolysaccharides; Macro	2022
Taurine Chloramine Inhibits Leukocyte Migration by Suppressing Actin Polymerization and Extracellular Signal-Regulated Kinase. Advances in experimental medicine and biology, 2022, Volume: 1370 Topics: Actins; Animals; Extracellular Signal-Regulated MAP Kinases; Inflammation; Lipopolysaccharides; Mamm	2022
Taurine inhibits hydrogen peroxide-induced oxidative stress, inflammatory response and apoptosis in liver of Monopterus albus. Fish & shellfish immunology, 2022, Volume: 128 Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Beclin-1; Environmental Biomarkers; Hy	2022
Metabonomics profile analysis in inflammation-induced preterm birth and the potential role of metabolites in regulating premature cervical ripening. Reproductive biology and endocrinology : RB&E, 2022, Sep-06, Volume: 20, Issue:1 Topics: Animals; Cervical Ripening; Female; Humans; Infant, Newborn; Inflammation; Mice; Mice, Inbred C57BL;	2022
Taurine mitigates the development of pulmonary inflammation, oxidative stress, and histopathological alterations in a rat model of bile duct ligation. Naunyn-Schmiedeberg's archives of pharmacology, 2022, Volume: 395, Issue:12 Topics: Animals; Antioxidants; Bile Ducts; Cholestasis; Fibrosis; Inflammation; Ligation; Liver; Liver Cirrh	2022
Dietary taurine supplementation counteracts deoxynivalenol-induced liver injury via alleviating oxidative stress, mitochondrial dysfunction, apoptosis, and inflammation in piglets. Ecotoxicology and environmental safety, 2023, Mar-15, Volume: 253 Topics: Animal Feed; Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury, Chronic; Diet	2023
Pretransplant systemic metabolic profiles in allogeneic hematopoietic stem cell transplant recipients - identification of patient subsets with increased transplant-related mortality. Transplantation and cellular therapy, 2023, Volume: 29, Issue:6 Topics: Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Inflammation; Leukemia, Myel	2023
The protective effect of taurine on cyclophosphamide-induced testicular toxicity in rats. Pakistan journal of pharmaceutical sciences, 2023, Volume: 36, Issue:5(Special) Topics: Animals; Antioxidants; Cyclophosphamide; Inflammation; Male; Oxidative Stress; Rats; Rats, Sprague-D	2023
Taurine modulates hepatic oxidative status and gut inflammatory markers of European seabass (Dicentrarchus labrax) fed plant feedstuffs-based diets. Amino acids, 2019, Volume: 51, Issue:9 Topics: Animal Feed; Animals; Antioxidants; Apoptosis; Bass; Caspase 3; Caspase 9; Diet; Glucosephosphate De	2019
Ribose-Taurine Suppresses Inflammation Through NF-κB Regulation in Activated RAW 264.7 Macrophages. Advances in experimental medicine and biology, 2019, Volume: 1155 Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Cytokines; Dinoprostone; Inflammation; Lipopoly	2019
Emodin relieved lipopolysaccharide-evoked inflammatory damage in WI-38 cells by up-regulating taurine up-regulated gene 1. BioFactors (Oxford, England), 2020, Volume: 46, Issue:5 Topics: Apoptosis; Cell Line; Cell Survival; Chemokine CCL2; Emodin; Humans; Inflammation; Interleukin-6; Li	2020
Dexmedetomidine reduces the inflammation and apoptosis of doxorubicin-induced myocardial cells. Experimental and molecular pathology, 2020, Volume: 113 Topics: Adenylate Kinase; Animals; Apoptosis; Cell Cycle Proteins; Cell Line; Cell Survival; Dexmedetomidine	2020
Impact of locking solutions on conditioning biofilm formation in tunnelled haemodialysis catheters and inflammatory response activation. The journal of vascular access, 2021, Volume: 22, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Anticoagulants; Biofilms; Catheter-Related In	2021
Taurine Attenuates Catabolic Processes Related to the Onset of Sarcopenia. International journal of molecular sciences, 2020, Nov-23, Volume: 21, Issue:22 Topics: Aging; Amino Acids; Animals; Antioxidants; Autophagy; Gene Expression Regulation, Developmental; Hum	2020
Dietary taurine modulates hepatic oxidative status, ER stress and inflammation in juvenile turbot (Scophthalmus maximus L.) fed high carbohydrate diets. Fish & shellfish immunology, 2021, Volume: 109 Topics: Animal Feed; Animals; Diet; Diet, Carbohydrate Loading; Dietary Supplements; Dose-Response Relations	2021
The role of taurine derivatives in the putative therapy of COVID-19-induced inflammation. Irish journal of medical science, 2022, Volume: 191, Issue:1 Topics: COVID-19; Humans; Inflammation; SARS-CoV-2; Taurine	2022
Taurine Alleviates Sympathetic Innervation by Inhibiting NLRP3 Inflammasome in Postinfarcted Rats. Journal of cardiovascular pharmacology, 2021, 04-15, Volume: 77, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Inflammasomes; Inflammation; Interleukin-	2021
The nephroprotective properties of taurine-amikacin treatment in rats are mediated through HSP25 and TLR-4 regulation. The Journal of antibiotics, 2021, Volume: 74, Issue:9 Topics: Amikacin; Animals; Anti-Bacterial Agents; Apoptosis; Blood Urea Nitrogen; Creatinine; Dose-Response	2021
Combined hyperosmolarity and inflammatory conditions in stressed human corneal epithelial cells and macrophages to evaluate osmoprotective agents as potential DED treatments. Experimental eye research, 2021, Volume: 211 Topics: Animals; Apoptosis; Betaine; Carnitine; Cell Survival; Cells, Cultured; Dry Eye Syndromes; Epitheliu	2021
Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain-pituitary-gonadal axis in male rats. Canadian journal of physiology and pharmacology, 2017, Volume: 95, Issue:9 Topics: Animals; Biomarkers; Body Weight; Brain; Caspase 3; Epididymis; Inflammation; Male; Oxidative Stress	2017
The potential protective role of taurine against experimental allergic inflammation. Life sciences, 2017, Sep-01, Volume: 184 Topics: Animals; Caspase 1; Cell Line; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug;	2017
Taurine alleviates lipopolysaccharide‑induced liver injury by anti‑inflammation and antioxidants in rats. Molecular medicine reports, 2017, Volume: 16, Issue:5 Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced	2017
Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response. Endocrinology, 2017, 10-01, Volume: 158, Issue:10 Topics: Angiotensin II; Animals; Cell Line, Tumor; Cytokines; Diabetes Mellitus, Type 2; eIF-2 Kinase; Endop	2017
Role of heme oxygenase-1 in potentiation of phagocytic activity of macrophages by taurine chloramine: Implications for the resolution of zymosan A-induced murine peritonitis. Cellular immunology, 2018, Volume: 327 Topics: Animals; Antioxidants; Heme Oxygenase-1; Inflammation; Macrophages; Macrophages, Peritoneal; Mice; M	2018
Acamprosate Protects Against Adjuvant-Induced Arthritis in Rats via Blocking the ERK/MAPK and NF-κB Signaling Pathway. Inflammation, 2018, Volume: 41, Issue:4 Topics: Acamprosate; Animals; Arthritis, Experimental; Inflammation; Male; MAP Kinase Signaling System; NF-k	2018
Taurine enhances the protective effect of Dexmedetomidine on sepsis-induced acute lung injury via balancing the immunological system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 103 Topics: Acute Lung Injury; Animals; Apoptosis; Caspase 3; Dexmedetomidine; Immune System; Inflammation; Ki-6	2018
Taurine regulates mucosal barrier function to alleviate lipopolysaccharide-induced duodenal inflammation in chicken. Amino acids, 2018, Volume: 50, Issue:11 Topics: Animals; Chickens; Duodenitis; Duodenum; Inflammation; Intestinal Mucosa; Lipopolysaccharides; Poult	2018
Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury. Molecular medicine reports, 2018, Volume: 18, Issue:5 Topics: Acetylcholinesterase; Animals; Antioxidants; Apoptosis; Astrocytes; bcl-2-Associated X Protein; Brai	2018
Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway. Cell death & disease, 2018, 09-20, Volume: 9, Issue:10 Topics: Animals; Arsenic; Autophagy; Cell Survival; Hep G2 Cells; Humans; Inflammation; Mice; Mice, Inbred C	2018
Taurine ameliorates oxidative stress induced inflammation and ER stress mediated testicular damage in STZ-induced diabetic Wistar rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019, Volume: 124 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Biomarkers; Catalase; Chemokines; Diabet	2019
Inorganic arsenic induces pyroptosis and pancreatic β cells dysfunction through stimulating the IRE1α/TNF-α pathway and protective effect of taurine. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019, Volume: 125 Topics: Animals; Anti-Inflammatory Agents; Arsenic Trioxide; Cell Line, Tumor; Endoplasmic Reticulum Stress;	2019
Fructus Gardeniae-induced gastrointestinal injury was associated with the inflammatory response mediated by the disturbance of vitamin B6, phenylalanine, arachidonic acid, taurine and hypotaurine metabolism. Journal of ethnopharmacology, 2019, May-10, Volume: 235 Topics: Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Gardenia; Gastrointestinal Diseases	2019
A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss. Human molecular genetics, 2019, 07-01, Volume: 28, Issue:13 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biomarkers; Blood-Brain Barrier; Disease Models,	2019
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan. Nature communications, 2019, 04-01, Volume: 10, Issue:1 Topics: Acetylcarnitine; Animals; Canavanine; Carnitine; Case-Control Studies; Disease Models, Animal; Disea	2019
Antioxidants inhibit SAA formation and pro-inflammatory cytokine release in a human cell model of alkaptonuria. Rheumatology (Oxford, England), 2013, Volume: 52, Issue:9 Topics: Acetylcysteine; Alkaptonuria; Antioxidants; Ascorbic Acid; Cell Line; Chondrocytes; Cytokines; Human	2013
Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages. Molecular nutrition & food research, 2013, Volume: 57, Issue:12 Topics: Adipose Tissue; Animals; Bone Marrow Cells; Cytokines; Diet, High-Fat; Hyperglycemia; Inflammation;	2013
Beneficial effects of cod protein on inflammatory cell accumulation in rat skeletal muscle after injury are driven by its high levels of arginine, glycine, taurine and lysine. PloS one, 2013, Volume: 8, Issue:10 Topics: Amino Acids; Animals; Arginine; Cyclooxygenase 2; Dietary Proteins; Eating; Fish Proteins; Gadiforme	2013
Effects of taurine supplementation on hepatic markers of inflammation and lipid metabolism in mothers and offspring in the setting of maternal obesity. PloS one, 2013, Volume: 8, Issue:10 Topics: Animals; Animals, Newborn; Biomarkers; Body Weight; Dietary Supplements; Disease Models, Animal; Fem	2013
Taurine chloramine modulates the expression of adipokines through inhibition of the STAT-3 signaling pathway in differentiated human adipocytes. Amino acids, 2013, Volume: 45, Issue:6 Topics: Adipocytes; Adipokines; Cell Differentiation; Cells, Cultured; Humans; Inflammation; Signal Transduc	2013
Chronic ethanol ingestion induces oxidative kidney injury through taurine-inhibitable inflammation. Free radical biology & medicine, 2014, Volume: 69 Topics: Acute Kidney Injury; Animals; Antioxidants; Cytochrome P-450 CYP2E1; Ethanol; Free Radicals; Humans;	2014
Taurine improves functional and histological outcomes and reduces inflammation in traumatic brain injury. Neuroscience, 2014, Apr-25, Volume: 266 Topics: Animals; Brain Injuries; Disease Models, Animal; Fluorescent Antibody Technique; Inflammation; Male;	2014
Tunneled catheters with taurolidine-citrate-heparin lock solution significantly improve the inflammatory profile of hemodialysis patients. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticoagulants; C-Reactive Protein; Catheter-	2014
N-Acylethanolamine-hydrolyzing acid amidase inhibition increases colon N-palmitoylethanolamine levels and counteracts murine colitis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, Volume: 29, Issue:2 Topics: Amides; Amidohydrolases; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Chromatography, High	2015
Taurine Chloramine Stimulates Efferocytosis Through Upregulation of Nrf2-Mediated Heme Oxygenase-1 Expression in Murine Macrophages: Possible Involvement of Carbon Monoxide. Antioxidants & redox signaling, 2015, Jul-10, Volume: 23, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Animals; Carbon Monoxide; Cytoskeletal Proteins; Disease Model	2015
Impact of Taurine on Innate and Adaptive Immunity as the Result of HOCl Neutralization. Advances in experimental medicine and biology, 2015, Volume: 803 Topics: Adaptive Immunity; Albumins; alpha 1-Antitrypsin; Animals; Antibody Formation; Hypochlorous Acid; Im	2015
The effects of taurine administration against inflammation in heavily exercised skeletal muscle of rats. Advances in experimental medicine and biology, 2015, Volume: 803 Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Drinking; Eating; Inflammation; In	2015
Taurine Attenuates Hepatic Inflammation in Chronic Alcohol-Fed Rats Through Inhibition of TLR4/MyD88 Signaling. Journal of medicinal food, 2015, Volume: 18, Issue:12 Topics: Animals; C-Reactive Protein; Chemical and Drug Induced Liver Injury; Ethanol; Inflammation; Inflamma	2015
Specific role of taurine in the 8-brominated-2'-deoxyguanosine formation. Archives of biochemistry and biophysics, 2015, Nov-15, Volume: 586 Topics: Animals; Bromates; Chromatography, High Pressure Liquid; Deoxyguanosine; Halogenation; Humans; Hypoc	2015
Serum Taurine and Stroke Risk in Women: A Prospective, Nested Case-Control Study. PloS one, 2016, Volume: 11, Issue:2 Topics: Adult; Aged; Anti-Inflammatory Agents; Antioxidants; Bile Acids and Salts; Blood Pressure; Case-Cont	2016
Diverse effects of taurine on vascular response and inflammation in GSH depletion model in rabbits. European review for medical and pharmacological sciences, 2016, Volume: 20, Issue:7 Topics: Acetylcholine; Animals; Aorta; Buthionine Sulfoximine; Carotid Arteries; Glutathione; Immunohistoche	2016
Chronic treatment with taurine after intracerebroventricular streptozotocin injection improves cognitive dysfunction in rats by modulating oxidative stress, cholinergic functions and neuroinflammation. Neurochemistry international, 2017, Volume: 108 Topics: Animals; Choline O-Acetyltransferase; Cognitive Dysfunction; Drug Administration Schedule; Inflammat	2017
Distinct influence of atypical 1,4-dihydropyridine compounds in azidothymidine-induced neuro- and cardiotoxicity in mice ex vivo. Basic & clinical pharmacology & toxicology, 2008, Volume: 103, Issue:5 Topics: Animals; Anti-HIV Agents; Apoptosis; Caspase 3; Cerebral Cortex; Dihydropyridines; Gene Expression R	2008
Oxidative and nitrosative stress and apoptosis in the liver of rats fed on high methionine diet: protective effect of taurine. Nutrition (Burbank, Los Angeles County, Calif.), 2009, Volume: 25, Issue:4 Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; bcl-2-Associate	2009
Taurine haloamines and heme oxygenase-1 cooperate in the regulation of inflammation and attenuation of oxidative stress. Advances in experimental medicine and biology, 2009, Volume: 643 Topics: Animals; Carbon Monoxide; Cytokines; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Inflammation;	2009
Protection of bleomycin-induced fibrosis and inflammation by taurine. International immunopharmacology, 2009, Volume: 9, Issue:7-8 Topics: Animals; Bleomycin; Cell Movement; Chemotaxis; Chromatography, High Pressure Liquid; Cytoprotection;	2009
Taurine reduces inflammatory responses after spinal cord injury. Journal of neurotrauma, 2010, Volume: 27, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cyclooxygenase 2; Enzyme-Linked Immunosorbent	2010
The Immune system's moderating response to inflammation relieves autistic behavior: response to Peter Good. Neuropsychology review, 2011, Volume: 21, Issue:1 Topics: Autistic Disorder; Child; Cytokines; Humans; Immune System; Inflammation; Parasympathetic Nervous Sy	2011
Anti-inflammatory mechanism of taurine against ischemic stroke is related to down-regulation of PARP and NF-κB. Amino acids, 2012, Volume: 42, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Brain; Cell Death; Disease Models, Animal; Gene Expression Regula	2012
Taurine chloramine inhibits NO and TNF-α production in zymosan plus interferon-γ activated RAW 264.7 cells. Journal of drugs in dermatology : JDD, 2011, Volume: 10, Issue:6 Topics: Animals; Blotting, Western; Dose-Response Relationship, Drug; Inflammation; Interferon-gamma; Macrop	2011
Taurine attenuates Streptococcus uberis-induced mastitis in rats by increasing T regulatory cells. Amino acids, 2012, Volume: 42, Issue:6 Topics: Acetylglucosaminidase; Animals; Anti-Inflammatory Agents, Non-Steroidal; CD4 Lymphocyte Count; Disea	2012
Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease. American journal of physiology. Regulatory, integrative and comparative physiology, 2011, Volume: 301, Issue:6 Topics: Animals; Cell Death; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Diet; Endoplasmic Ret	2011
Acamprosate modulates experimental autoimmune encephalomyelitis. Inflammopharmacology, 2012, Volume: 20, Issue:1 Topics: Acamprosate; Animals; Blood-Brain Barrier; Body Weight; Demyelinating Diseases; Encephalomyelitis, A	2012
The efficiency of proanthocyanidin in an experimental pulmonary fibrosis model: comparison with taurine. Inflammation, 2012, Volume: 35, Issue:4 Topics: Animals; Antioxidants; Bleomycin; Grape Seed Extract; Hydroxyproline; Inflammation; Lung; Lymphocyte	2012
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. Nature, 2012, Jul-05, Volume: 487, Issue:7405 Topics: Animals; Bile Acids and Salts; Bilophila; Colitis; Diet, Fat-Restricted; Dietary Fats; Inflammation;	2012
Taurine enhances antinociception produced by a COX-2 inhibitor in an inflammatory pain model. Inflammation, 2013, Volume: 36, Issue:3 Topics: Analgesics; Animals; Carrageenan; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Synergism; Drug Thera	2013
Thiotaurine prevents apoptosis of human neutrophils: a putative role in inflammation. Advances in experimental medicine and biology, 2013, Volume: 775 Topics: Apoptosis; Caspase 3; Caspase Inhibitors; Cytoprotection; Glutathione; Humans; Inflammation; Neutrop	2013
Sulphoacetaldehyde as a product of taurine chloramine peroxidation at site of inflammation. Amino acids, 2002, Volume: 22, Issue:2 Topics: Acetaldehyde; Chromatography, High Pressure Liquid; Horseradish Peroxidase; Hydrogen Peroxide; Infla	2002
Efficiency of a cysteine-taurine-threonine-serine supplemented parenteral nutrition in an experimental model of acute inflammation. Intensive care medicine, 2003, Volume: 29, Issue:10 Topics: Acute Disease; Animals; Cysteine; Dietary Supplements; Inflammation; Male; Parenteral Nutrition; Pro	2003
Anti-inflammatory activities of taurine chloramine: implication for immunoregulation and pathogenesis of rheumatoid arthritis. Advances in experimental medicine and biology, 2003, Volume: 526 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Humans; Inflammation;	2003
Taurine is involved in oxidation of IkappaB alpha at Met45: N-halogenated taurine and anti-inflammatory action. Advances in experimental medicine and biology, 2003, Volume: 526 Topics: Animals; Humans; I-kappa B Proteins; Inflammation; Jurkat Cells; Methionine; NF-KappaB Inhibitor alp	2003
Taurine chloramine modifies carrageenin- and casein-induced inflammation in the rat. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2004, Volume: 53 Suppl 1 Topics: Animals; Carrageenan; Caseins; Inflammation; Inflammation Mediators; Male; Neutrophils; Rats; Rats,	2004
Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species. The Journal of biological chemistry, 2004, Oct-08, Volume: 279, Issue:41 Topics: Arteries; Arteriosclerosis; Coronary Artery Disease; Coronary Vessels; Dose-Response Relationship, D	2004
Taurine chloramine and taurine bromamine induce heme oxygenase-1 in resting and LPS-stimulated J774.2 macrophages. Amino acids, 2004, Volume: 27, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Line; Cell Survival; Dose-Response Relati	2004
Is there a role of taurine bromamine in inflammation? Interactive effects with nitrite and hydrogen peroxide. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2005, Volume: 54, Issue:1 Topics: Animals; Anti-Bacterial Agents; Cells, Cultured; Cytokines; Drug Interactions; Drug Stability; Hydro	2005
Detection of the inhibitory neurotransmitter GABA in macrophages by magnetic resonance spectroscopy. Journal of leukocyte biology, 2005, Volume: 78, Issue:2 Topics: Amino Acids; Animals; Biomarkers; Brain Injuries; Cell Communication; Cell Extracts; Cell Line; Cell	2005
Taurine-chloramine is a potent antiinflammatory substance. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2006, Volume: 55 Suppl 1 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Histamine; Inflammation; Male; Rats; Rea	2006
Prolastin aerosol therapy and sputum taurine in cystic fibrosis. Clinical and investigative medicine. Medecine clinique et experimentale, 2006, Volume: 29, Issue:4 Topics: Administration, Inhalation; Adolescent; Adult; alpha 1-Antitrypsin; Cystic Fibrosis; Female; Humans;	2006
Accumulation of taurine in tumor and inflammatory lesions. Advances in experimental medicine and biology, 2006, Volume: 583 Topics: Animals; Cell Line; Inflammation; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; N	2006
Neuroprotection by taurine and taurine analogues. Advances in experimental medicine and biology, 2006, Volume: 583 Topics: Animals; Antioxidants; Catalase; Cell Line; Free Radical Scavengers; Glutathione; Inflammation; Live	2006
Anti-inflammatory effects of taurine derivatives (taurine chloramine, taurine bromamine, and taurolidine) are mediated by different mechanisms. Advances in experimental medicine and biology, 2006, Volume: 583 Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Chloramines; Enzyme Induction; Heme Oxygenase-1;	2006
Taurine chloramine inhibits the synthesis of nitric oxide and the release of tumor necrosis factor in activated RAW 264.7 cells. Journal of leukocyte biology, 1993, Volume: 54, Issue:2 Topics: Amino Acid Oxidoreductases; Animals; Biological Transport; Cell Line; Inflammation; Interferon-gamma	1993
Effects of in-vivo administration of taurine and HEPES on the inflammatory response in rats. The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:9 Topics: Animals; Carrageenan; Drug Administration Routes; Edema; Female; Half-Life; HEPES; Inflammation; Inj	1994
Glycosaminoglycans regulate elastase inhibition by oxidized secretory leukoprotease inhibitor. The American journal of physiology, 1997, Volume: 272, Issue:3 Pt 1 Topics: Glycosaminoglycans; Heparin; Humans; Inflammation; Kinetics; Leukocyte Elastase; Oxidation-Reduction	1997
Uptake of taurine and taurine chloramine in murine macrophages and their distribution in mice with experimental inflammation. Advances in experimental medicine and biology, 1998, Volume: 442 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Humans; Inflammation; Macrophages	1998
Initiation of rapid, P53-dependent growth arrest in cultured human skin fibroblasts by reactive chlorine species. Archives of biochemistry and biophysics, 2000, May-01, Volume: 377, Issue:1 Topics: Cell Division; Cell Survival; Cells, Cultured; Chloramines; Cyclin-Dependent Kinase Inhibitor p21; C	2000
Age-dependent changes in 24-hour rhythms of thymic and circulating growth hormone and adrenocorticotropin in rats injected with Freund's adjuvant. Neuroimmunomodulation, 2001, Volume: 9, Issue:5 Topics: Adrenocorticotropic Hormone; Aging; Animals; Aspartic Acid; Behavior, Animal; Chronobiology Disorder	2001
Abatement of bleomycin-induced increases in vascular permeability, inflammatory cell infiltration, and fibrotic lesions in hamster lungs by combined treatment with taurine and niacin. Laboratory investigation; a journal of technical methods and pathology, 1992, Volume: 67, Issue:2 Topics: Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Cell Membrane Permeability; Cricetinae; Drug Thera	1992
Influence of taurine and a substituted taurine on the respiratory burst pathway in the inflammatory response. Biochemical Society transactions, 1991, Volume: 19, Issue:1 Topics: Calcimycin; Dinoprostone; HEPES; Humans; Inflammation; Leukotriene B4; Luminescent Measurements; Neu	1991
Effects of neutrophil-derived oxidants on intestinal permeability, electrolyte transport, and epithelial cell viability. Inflammation, 1990, Volume: 14, Issue:5 Topics: Animals; Body Water; Cell Membrane Permeability; Chloramines; Edetic Acid; Electrolytes; Epithelium;	1990
Effect of temperature on production of hypochlorous acid by stimulated human neutrophils. The Journal of laboratory and clinical medicine, 1986, Volume: 107, Issue:1 Topics: Cell Survival; Horseradish Peroxidase; Humans; Hydrogen Peroxide; Hypochlorous Acid; In Vitro Techni	1986
Taurine protects hamster bronchioles from acute NO2-induced alterations. A histologic, ultrastructural, and freeze-fracture study. The American journal of pathology, 1986, Volume: 125, Issue:3 Topics: Animals; Bronchi; Cricetinae; Freeze Fracturing; Guinea Pigs; Horseradish Peroxidase; Inflammation;	1986

taurine and Innate Inflammatory Response

Research Excerpts

Research

Studies (118)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Changes in Serum Concentration of Inflammatory Biomarkers (TNF-alpha)

Changes in Sputum Concentration of Inflammatory Biomarkers (G-CSF)

Changes in Sputum Concentration of Inflammatory Biomarkers (IL-6)

Changes in Clinical Data Scores (Other Than Sputum Production, Dyspnea and Global Symptoms)

Changes in FEV1, FEF25, and FEFmax

Changes in Other Spirometric Variables

Changes in Pulse Oximetry, FEV1/FVC, and FEF50.

Changes in Score for Sputum Production, Dyspnea and Global Symptoms

Changes in Serum Concentration of Inflammatory Biomarkers (Other Than TNF-alpha)

Changes in Sputum Concentration of Inflammatory Biomarkers (Other Than IL-6 and G-CSF)

Reviews

Trials

Other Studies

Article	Year
Dietary taurine supplementation attenuates lipopolysaccharide-induced inflammatory responses and oxidative stress of broiler chickens at an early age. Journal of animal science, 2020, Oct-01, Volume: 98, Issue:10 Topics: Animal Feed; Animals; Antioxidants; Chickens; Cytokines; Diet; Dietary Supplements; Gene Expression	2020
Effects of taurine on markers of muscle damage, inflammatory response and physical performance in triathletes. The Journal of sports medicine and physical fitness, 2018, Volume: 58, Issue:9 Topics: Adult; Athletic Performance; Bicycling; Biomarkers; Creatine Kinase; Cross-Over Studies; Dietary Sup	2018
Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2018, Volume: 43, Issue:7 Topics: Aged; Aged, 80 and over; Biomarkers; Blood-Brain Barrier; Cognition; Cytokines; Exercise; Female; Fo	2018
RandomiSed clinical trial assessing Use of an anti-inflammatoRy aGent in attenUating peri-operatiVe inflAmmatioN in non-meTastatic colon cancer - the S.U.R.G.U.V.A.N.T. trial. BMC cancer, 2018, Aug-06, Volume: 18, Issue:1 Topics: Aged; Anti-Inflammatory Agents; Antineoplastic Agents; Biomarkers; Chemotherapy, Adjuvant; Colectomy	2018
Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine β-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial. Journal of inherited metabolic disease, 2019, Volume: 42, Issue:3 Topics: Adolescent; Adult; Biomarkers; Brachial Artery; Child; Cystathionine beta-Synthase; Female; Homocyst	2019
Effects of taurine supplementation following eccentric exercise in young adults. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2014, Volume: 39, Issue:1 Topics: Dietary Supplements; Exercise; Humans; Inflammation; Male; Muscle, Skeletal; Oxidative Stress; Tauri	2014
Impact of cholesterol lowering treatment on plasma kynurenine and tryptophan concentrations in chronic kidney disease: relationship with oxidative stress improvement. Nutrition, metabolism, and cardiovascular diseases : NMCD, 2015, Volume: 25, Issue:2 Topics: Aged; Allantoin; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dose-Res	2015