Page last updated: 2024-10-20

taurine and Depressive Disorder, Major

taurine has been researched along with Depressive Disorder, Major in 7 studies

Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)

Research Excerpts

ExcerptRelevanceReference
"Taurine is an important amino acid required for brain development."5.91Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss. ( Cai, G; Fan, Z; Han, J; Li, X; Li, Y; Luo, D; Wang, R; Wu, S; Zhang, H; Zhang, L; Zhu, Y; Zhuo, L, 2023)
"Taurine is an important amino acid required for brain development."1.91Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss. ( Cai, G; Fan, Z; Han, J; Li, X; Li, Y; Luo, D; Wang, R; Wu, S; Zhang, H; Zhang, L; Zhu, Y; Zhuo, L, 2023)
"Taurine transporter was present in 16% of CD4+ and CD8+ lymphocytes in controls and patients."1.33Taurine transport and transporter localization in peripheral blood lymphocytes of controls and major depression patients. ( Fazzino, F; Lima, L; Mata, S; Urbina, M, 2006)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Zhu, Y1
Wang, R1
Fan, Z1
Luo, D1
Cai, G1
Li, X1
Han, J1
Zhuo, L1
Zhang, L1
Zhang, H1
Li, Y1
Wu, S1
Helton, SG1
Lohoff, FW1
Raj, YP1
Witte, J1
Bentley, K1
Evins, AE1
Clain, AJ1
Baer, L1
Pedrelli, P1
Fava, M1
Mischoulon, D1
Sher, L1
Fazzino, F1
Urbina, M1
Mata, S1
Lima, L1
Maes, M1
Verkerk, R1
Vandoolaeghe, E1
Lin, A1
Scharpé, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-Blind, Placebo-Controlled Study of Acamprosate Added to Escitalopram and Behavioral Treatment in Major Depressive Disorder (MDD) With Comorbid Alcohol Abuse/Dependence[NCT00452543]Phase 423 participants (Actual)Interventional2007-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Mean Score on the Hamilton Rating Scale for Depression -- 17 Items (HAM-D-17)

Scores on the HAM-D-17 typically fall into the following ranges: a) Not depressed: 0-7; b) Mildly depressed: 7-15; c) Moderately depressed: 15-25; d) Severely depressed: over 25. A decrease of 50% or more in the Hamilton-D score is considered to be a positive response to treatment, while a score of 7 or less is considered typical of remission. We measure the change in total score from Baseline to Week 12 or week of early termination visit. (NCT00452543)
Timeframe: From baseline visit to Week 12 (or early discontinuation visit)

InterventionScores on a scale (Mean)
Escitalopram Plus Acamprosate-5.6
Escitalopram Plus Placebo-7.8

Total Drinking Days on the Alcohol Timeline Followback (TLFB)

The TLFB assesses recent drinking behavior. On the TLFB, clients retrospectively estimate their daily alcohol consumption in standard drinks over a time period ranging from 7 days to 24 months prior to the interview, and thus the measure provides quantitative estimates of alcohol use. One standard drink on the TLFB was defined as: 12 oz beer (5% alcohol by volume), 5 oz of wine (10-12% abv), 3 oz of fortified wine (16-18% abv), or 1-1.2 oz of hard liquor (86-100 proof; 43-50% abv). We measure the change from Baseline to Week 12 or week of early termination visit. (NCT00452543)
Timeframe: From Baseline visit to Week 12 (or early discontinuation visit)

InterventionDrinking days (Mean)
Escitalopram Plus Acamprosate61
Escitalopram Plus Placebo61

Total Drinks Consumed Per Drinking Day on the TLFB

Total Drinks Consumed per Drinking Day on the Time Line Follow Back. We measure the change from Baseline to Week 12 or week of early termination visit. (NCT00452543)
Timeframe: From Baseline visit to Week 12 (or early discontinuation visit)

InterventionDrinks consumed per drinking day (Mean)
Escitalopram Plus Acamprosate4
Escitalopram Plus Placebo4

Total Drinks Consumed Per Week on the TLFB

Total Drinks Consumed per Week on the Time Line Follow Back. We measure the change from Baseline to Week 12 or week of early termination visit. (NCT00452543)
Timeframe: From Baseline visit to Week 12 (or early discontinuation visit)

InterventionDrinks consumed per week (Mean)
Escitalopram Plus Acamprosate15
Escitalopram Plus Placebo15

Reviews

2 reviews available for taurine and Depressive Disorder, Major

ArticleYear
Pharmacogenetics of alcohol use disorders and comorbid psychiatric disorders.
    Psychiatry research, 2015, Dec-15, Volume: 230, Issue:2

    Topics: Acamprosate; Alcohol Deterrents; Alcohol-Related Disorders; Anxiety Disorders; Comorbidity; Depressi

2015
Alcoholism and suicidal behavior: a clinical overview.
    Acta psychiatrica Scandinavica, 2006, Volume: 113, Issue:1

    Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Antidepressive Agents, Tricyclic; Anxiety; Comorbidity;

2006

Trials

2 trials available for taurine and Depressive Disorder, Major

ArticleYear
A randomized, controlled, pilot study of acamprosate added to escitalopram in adults with major depressive disorder and alcohol use disorder.
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:6

    Topics: Acamprosate; Adult; Alcoholism; Citalopram; Depressive Disorder, Major; Diagnosis, Dual (Psychiatry)

2012
Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment-resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity.
    Acta psychiatrica Scandinavica, 1998, Volume: 97, Issue:4

    Topics: Adult; Aged; Alanine; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arginine; Asparagine;

1998

Other Studies

3 other studies available for taurine and Depressive Disorder, Major

ArticleYear
Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss.
    Cellular and molecular neurobiology, 2023, Volume: 43, Issue:2

    Topics: Amino Acids; Animals; Dendritic Spines; Depression; Depressive Disorder, Major; Mice; Mice, Inbred C

2023
Gambling on acamprosate: a case report.
    The Journal of clinical psychiatry, 2010, Volume: 71, Issue:9

    Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Antidepressive Agents, Second-Generation; Comorbidity;

2010
Taurine transport and transporter localization in peripheral blood lymphocytes of controls and major depression patients.
    Advances in experimental medicine and biology, 2006, Volume: 583

    Topics: Adolescent; Adult; Depressive Disorder, Major; Humans; Lymphocytes; Membrane Glycoproteins; Membrane

2006