taurine has been researched along with Brain Neoplasms in 27 studies
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy and tolerability of taurolidine, an antibacterial substance, was evaluated in a phase 2 trial enrolling patients with advanced melanoma." | 9.15 | The antibacterial substance, taurolidine in the second/third-line treatment of very advanced stage IV melanoma including brain metastases: results of a phase 2, open-label study. ( Baumann, K; Dummer, R; French, LE; Goldinger, SM; Imhof, L; Röthlisberger, P; Schad, K, 2011) |
| " In the cytotoxicity assay 100% of glioma cell lines (eight of eight) and 74% of ex vivo glioma cultures (14 of 19) demonstrated sensitivity to taurolidine, with a mean median effective concentration (EC50) of 51 +/- 28 microg/ml and 56 +/- 23 microg/ml, respectively." | 7.73 | Induction of reactive oxygen intermediates-dependent programmed cell death in human malignant ex vivo glioma cells and inhibition of the vascular endothelial growth factor production by taurolidine. ( Eugster, HP; Frei, K; Ishihara, H; Könü, D; Kubota, H; Möhler, H; Rodak, R; Yonekawa, Y, 2005) |
| "Taurine concentrations were determined in gliomas from 16 patients and in meningiomas from 15 patients." | 7.73 | Taurine concentration in human gliomas and meningiomas: tumoral, peritumoral, and extratumoral tissue. ( Cubillos, S; Lima, L; Obregón, F; Salazar, LA; Vargas, MF, 2006) |
| " The effects of inhibiting Na+ pump activity on cell volume and taurine efflux were evaluated in the human neuroblastoma cell line CHP-100." | 7.70 | Inhibition of Na+, K+-ATPase activates swelling-induced taurine efflux in a human neuroblastoma cell line. ( Al-Adawi, S; Basavappa, S; Ellory, JC; Errington, R; Huang, CC; Mobasheri, A, 1998) |
| "The activation of NK1 receptors on U373 MG human astrocytoma cells by substance P (SP) and related tachykinins was accompanied by an increase in taurine release and an accumulation of inositol phosphates." | 7.68 | Tachykinin-stimulated inositol phospholipid hydrolysis and taurine release from human astrocytoma cells. ( Lee, CM; Tung, WL; Young, JD, 1992) |
| "Glioma is one of the most lethal brain malignancies with unknown etiologies." | 5.46 | Capillary electrophoresis - Mass spectrometry metabolomics analysis revealed enrichment of hypotaurine in rat glioma tissues. ( Cao, Y; Fang, X; Gao, P; Ji, M; Liu, Y; Sun, A; Yu, Z; Zhang, Y; Zhao, L, 2017) |
| "Taurine was found to significantly correlate with apoptotic cell density (TUNEL) in both non-necrotic (R=0." | 5.35 | Taurine: a potential marker of apoptosis in gliomas. ( Bell, BA; Griffiths, JR; Howe, FA; Opstad, KS, 2009) |
| "The efficacy and tolerability of taurolidine, an antibacterial substance, was evaluated in a phase 2 trial enrolling patients with advanced melanoma." | 5.15 | The antibacterial substance, taurolidine in the second/third-line treatment of very advanced stage IV melanoma including brain metastases: results of a phase 2, open-label study. ( Baumann, K; Dummer, R; French, LE; Goldinger, SM; Imhof, L; Röthlisberger, P; Schad, K, 2011) |
| "A previous study showed that treatment of C6 glioma cells with 10 mM ammonium chloride monia") for 24 h decreases taurine uptake and evokes sodium-dependent taurine efflux, indicating reversal of the taurine transporter (TauT)-mediated transport as an underlying mechanism." | 3.73 | The role of protein kinase C and cyclic AMP in the ammonia-induced shift of the taurine uptake/efflux balance towards efflux in C6 cells. ( Albrecht, J; Dybel, A; Zabłocka, B; Zielińska, M, 2005) |
| " In the cytotoxicity assay 100% of glioma cell lines (eight of eight) and 74% of ex vivo glioma cultures (14 of 19) demonstrated sensitivity to taurolidine, with a mean median effective concentration (EC50) of 51 +/- 28 microg/ml and 56 +/- 23 microg/ml, respectively." | 3.73 | Induction of reactive oxygen intermediates-dependent programmed cell death in human malignant ex vivo glioma cells and inhibition of the vascular endothelial growth factor production by taurolidine. ( Eugster, HP; Frei, K; Ishihara, H; Könü, D; Kubota, H; Möhler, H; Rodak, R; Yonekawa, Y, 2005) |
| "Taurine concentrations were determined in gliomas from 16 patients and in meningiomas from 15 patients." | 3.73 | Taurine concentration in human gliomas and meningiomas: tumoral, peritumoral, and extratumoral tissue. ( Cubillos, S; Lima, L; Obregón, F; Salazar, LA; Vargas, MF, 2006) |
| " The concentration of taurine (Tau) in medulloblastomas was 29." | 3.72 | In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. ( Harada, K; Houkin, K; Tong, Z; Yamaki, T, 2004) |
| " The concentration of taurine (Tau) in medulloblastomas was 29." | 3.72 | In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard. ( Harada, K; Houkin, K; Tong, Z; Yamaki, T, 2004) |
| " The effects of inhibiting Na+ pump activity on cell volume and taurine efflux were evaluated in the human neuroblastoma cell line CHP-100." | 3.70 | Inhibition of Na+, K+-ATPase activates swelling-induced taurine efflux in a human neuroblastoma cell line. ( Al-Adawi, S; Basavappa, S; Ellory, JC; Errington, R; Huang, CC; Mobasheri, A, 1998) |
| "The activation of NK1 receptors on U373 MG human astrocytoma cells by substance P (SP) and related tachykinins was accompanied by an increase in taurine release and an accumulation of inositol phosphates." | 3.68 | Tachykinin-stimulated inositol phospholipid hydrolysis and taurine release from human astrocytoma cells. ( Lee, CM; Tung, WL; Young, JD, 1992) |
| "46 eligible patients with either anaplastic astrocytoma (AA) or glioblastoma (GBM) and clinical and computed-tomography-confirmed relapse following primary surgery and radiotherapy received oral tauromustine 130 mg/m2 every 5 weeks." | 2.67 | Phase II study of tauromustine in malignant glioma. ( Aapro, M; Demierre, B; Gregor, A; Ironside, JW; Malmström, P; Rampling, R; Rye, R; Sellar, R; Stewart, M; Whittle, IR, 1992) |
| "Taurine is an abundant amino acid in the brain that serves the central nervous system (CNS)." | 1.46 | Taurine-modified Ru(ii)-complex targets cancerous brain cells for photodynamic therapy. ( Deasy, K; Du, E; Hu, X; Mochizuki, T; Roy, S; Wang, P; Zhang, Y, 2017) |
| "Glioma is one of the most lethal brain malignancies with unknown etiologies." | 1.46 | Capillary electrophoresis - Mass spectrometry metabolomics analysis revealed enrichment of hypotaurine in rat glioma tissues. ( Cao, Y; Fang, X; Gao, P; Ji, M; Liu, Y; Sun, A; Yu, Z; Zhang, Y; Zhao, L, 2017) |
| "Taurine was found to significantly correlate with apoptotic cell density (TUNEL) in both non-necrotic (R=0." | 1.35 | Taurine: a potential marker of apoptosis in gliomas. ( Bell, BA; Griffiths, JR; Howe, FA; Opstad, KS, 2009) |
| "High-grade brain tumors are known to have a high rate of glucose (Glc) consumption." | 1.31 | High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging. ( Décorps, M; Rémy, C; von Kienlin , M; Ziegler, A, 2001) |
| "Total creatine was decreased in all brain tumors in comparison with normal brain tissues, but was relatively higher in neuroectodermal tumors than in other brain tumors." | 1.29 | Proton magnetic resonance spectroscopy of brain tumors: an in vitro study. ( Kajiwara, H; Kinoshita, Y; Koga, Y; Yokota, A, 1994) |
| " The absolute levels of TCNU obtained with a dose of 100 mg TCNU/kg bodyweight were at most time points, three to four times those obtained with dosage of 25 mg TCNU/kg." | 1.27 | Experimental cerebral and plasma pharmacokinetic studies of TCNU: implications for brain tumour chemotherapy. ( Macpherson, JS; Miller, JD; Smyth, J; Whittle, IR, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.11) | 18.7374 |
| 1990's | 7 (25.93) | 18.2507 |
| 2000's | 11 (40.74) | 29.6817 |
| 2010's | 6 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Du, E | 1 |
| Hu, X | 1 |
| Roy, S | 1 |
| Wang, P | 1 |
| Deasy, K | 1 |
| Mochizuki, T | 1 |
| Zhang, Y | 2 |
| Gao, P | 1 |
| Ji, M | 1 |
| Fang, X | 1 |
| Liu, Y | 1 |
| Yu, Z | 1 |
| Cao, Y | 1 |
| Sun, A | 1 |
| Zhao, L | 1 |
| Zawaski, JA | 1 |
| Sabek, OM | 1 |
| Voicu, H | 1 |
| Eastwood Leung, HC | 1 |
| Gaber, MW | 1 |
| Carlin, D | 1 |
| Babourina-Brooks, B | 1 |
| Arvanitis, TN | 1 |
| Wilson, M | 1 |
| Peet, AC | 1 |
| Opstad, KS | 1 |
| Bell, BA | 1 |
| Griffiths, JR | 1 |
| Howe, FA | 1 |
| Imhof, L | 1 |
| Goldinger, SM | 1 |
| Baumann, K | 1 |
| Schad, K | 1 |
| French, LE | 1 |
| Röthlisberger, P | 1 |
| Dummer, R | 1 |
| Robert, O | 1 |
| Sabatier, J | 1 |
| Desoubzdanne, D | 1 |
| Lalande, J | 1 |
| Balayssac, S | 1 |
| Gilard, V | 1 |
| Martino, R | 1 |
| Malet-Martino, M | 1 |
| Lehtimäki, KK | 1 |
| Valonen, PK | 1 |
| Griffin, JL | 1 |
| Väisänen, TH | 1 |
| Gröhn, OH | 1 |
| Kettunen, MI | 1 |
| Vepsäläinen, J | 1 |
| Ylä-Herttuala, S | 1 |
| Nicholson, J | 1 |
| Kauppinen, RA | 1 |
| Tong, Z | 2 |
| Yamaki, T | 2 |
| Harada, K | 2 |
| Houkin, K | 2 |
| Zielińska, M | 1 |
| Zabłocka, B | 1 |
| Dybel, A | 1 |
| Albrecht, J | 1 |
| Rodak, R | 1 |
| Kubota, H | 1 |
| Ishihara, H | 1 |
| Eugster, HP | 1 |
| Könü, D | 1 |
| Möhler, H | 1 |
| Yonekawa, Y | 1 |
| Frei, K | 1 |
| Cheema, TA | 1 |
| Ward, CE | 1 |
| Fisher, SK | 1 |
| Bergenheim, AT | 1 |
| Roslin, M | 1 |
| Ungerstedt, U | 1 |
| Waldenström, A | 1 |
| Henriksson, R | 1 |
| Ronquist, G | 1 |
| Cubillos, S | 1 |
| Obregón, F | 1 |
| Vargas, MF | 1 |
| Salazar, LA | 1 |
| Lima, L | 1 |
| Kinoshita, Y | 1 |
| Kajiwara, H | 1 |
| Yokota, A | 1 |
| Koga, Y | 1 |
| Rémy, C | 2 |
| Arús, C | 1 |
| Ziegler, A | 2 |
| Lai, ES | 1 |
| Moreno, A | 1 |
| Le Fur, Y | 1 |
| Décorps, M | 2 |
| Basavappa, S | 1 |
| Mobasheri, A | 1 |
| Errington, R | 1 |
| Huang, CC | 1 |
| Al-Adawi, S | 1 |
| Ellory, JC | 1 |
| Lelong, IH | 1 |
| Rebel, G | 1 |
| von Kienlin , M | 1 |
| De Micheli, E | 1 |
| Alfieri, A | 1 |
| Pinna, G | 1 |
| Bianchi, L | 1 |
| Colivicchi, MA | 1 |
| Melani, A | 1 |
| Pedata, F | 1 |
| Della Corte, L | 1 |
| Bricolo, A | 1 |
| Borg, J | 1 |
| Mark, J | 1 |
| Mandel, P | 1 |
| Lee, CM | 1 |
| Tung, WL | 1 |
| Young, JD | 1 |
| Gregor, A | 1 |
| Rampling, R | 1 |
| Aapro, M | 1 |
| Malmström, P | 1 |
| Whittle, IR | 3 |
| Rye, R | 1 |
| Stewart, M | 1 |
| Sellar, R | 1 |
| Demierre, B | 1 |
| Ironside, JW | 1 |
| MacPherson, JS | 2 |
| Miller, JD | 2 |
| Smyth, JF | 1 |
| Smyth, J | 1 |
| Snodgrass, SR | 1 |
| Iversen, LL | 1 |
3 trials available for taurine and Brain Neoplasms
| Article | Year |
|---|---|
The antibacterial substance, taurolidine in the second/third-line treatment of very advanced stage IV melanoma including brain metastases: results of a phase 2, open-label study.
Topics: Adult; Aged; Anti-Infective Agents; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Prot | 2011 |
Metabolic manipulation of glioblastoma in vivo by retrograde microdialysis of L-2, 4 diaminobutyric acid (DAB).
Topics: Aged; Aminobutyrates; Antimetabolites, Antineoplastic; Brain Neoplasms; Catheters, Indwelling; Dose- | 2006 |
Phase II study of tauromustine in malignant glioma.
Topics: Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Drug Administration Schedule; Drug Evalu | 1992 |
24 other studies available for taurine and Brain Neoplasms
| Article | Year |
|---|---|
Taurine-modified Ru(ii)-complex targets cancerous brain cells for photodynamic therapy.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Death; Cell Line; Cell Proliferation; Cell Sur | 2017 |
Capillary electrophoresis - Mass spectrometry metabolomics analysis revealed enrichment of hypotaurine in rat glioma tissues.
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Brain Neoplasms; Cell Line, Tumor; Electroph | 2017 |
Effect of Brain Tumor Presence During Radiation on Tissue Toxicity: Transcriptomic and Metabolic Changes.
Topics: Allografts; Animals; Biopsy; Brain; Brain Neoplasms; gamma-Aminobutyric Acid; Gene Expression Profil | 2017 |
Short-acquisition-time JPRESS and its application to paediatric brain tumours.
Topics: Adult; Biomarkers, Tumor; Brain; Brain Neoplasms; Child; Female; Glycine; Healthy Volunteers; Humans | 2019 |
Taurine: a potential marker of apoptosis in gliomas.
Topics: Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Cell Count; Glioma; Humans; In Situ Nick-End Labeling | 2009 |
pH optimization for a reliable quantification of brain tumor cell and tissue extracts with (1)H NMR: focus on choline-containing compounds and taurine.
Topics: Brain; Brain Chemistry; Brain Neoplasms; Choline; Glioma; Humans; Hydrogen-Ion Concentration; Magnet | 2011 |
Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro.
Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Choline; Diffusion; Ganciclovir; Genet | 2003 |
In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Cerebellar Neoplasms; C | 2004 |
In vivo quantification of the metabolites in normal brain and brain tumors by proton MR spectroscopy using water as an internal standard.
Topics: Adult; Aged; Aspartic Acid; Body Water; Brain; Brain Neoplasms; Child; Child, Preschool; Choline; Cr | 2004 |
The role of protein kinase C and cyclic AMP in the ammonia-induced shift of the taurine uptake/efflux balance towards efflux in C6 cells.
Topics: Ammonia; Animals; Brain Neoplasms; Bucladesine; Cell Line, Tumor; Cyclic AMP; Enzyme Activators; Gli | 2005 |
Induction of reactive oxygen intermediates-dependent programmed cell death in human malignant ex vivo glioma cells and inhibition of the vascular endothelial growth factor production by taurolidine.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Brain Neoplasms; | 2005 |
Subnanomolar concentrations of thrombin enhance the volume-sensitive efflux of taurine from human 1321N1 astrocytoma cells.
Topics: Animals; Animals, Newborn; Astrocytoma; Brain Neoplasms; Calcium; Calcium-Calmodulin-Dependent Prote | 2005 |
Taurine concentration in human gliomas and meningiomas: tumoral, peritumoral, and extratumoral tissue.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Glioma; Humans; Image Processing, Computer-Assisted; Male; | 2006 |
Proton magnetic resonance spectroscopy of brain tumors: an in vitro study.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Neoplasms; Child; C | 1994 |
In vivo, ex vivo, and in vitro one- and two-dimensional nuclear magnetic resonance spectroscopy of an intracerebral glioma in rat brain: assignment of resonances.
Topics: Amino Acids; Animals; Brain; Brain Neoplasms; Choline; Fatty Acids, Nonesterified; Glioma; Lactates; | 1994 |
Inhibition of Na+, K+-ATPase activates swelling-induced taurine efflux in a human neuroblastoma cell line.
Topics: Biological Transport; Brain Neoplasms; Cell Size; Humans; Neuroblastoma; Sodium-Potassium-Exchanging | 1998 |
In vitro taurine uptake into cell culture influenced by using media with or without CO2.
Topics: Adrenergic beta-Agonists; Brain Neoplasms; Buffers; Carbon Dioxide; Cell Division; Cell Line; Cells, | 1998 |
High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging.
Topics: Alanine; Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Ethanolamines; Female; Glioma; | 2001 |
Extracellular levels of taurine in tumoral, peritumoral and normal brain tissue in patients with malignant glioma: an intraoperative microdialysis study.
Topics: Amino Acids; Brain; Brain Neoplasms; Extracellular Space; Female; Glioblastoma; Glioma; Humans; Male | 2000 |
Effects of amino acids on calcium uptake by glial and neuroblastoma cells.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Neoplasms; Calcimycin; Calcium; Clone Cells; Cricetinae; | 1979 |
Tachykinin-stimulated inositol phospholipid hydrolysis and taurine release from human astrocytoma cells.
Topics: Alkaloids; Astrocytoma; Brain Neoplasms; Down-Regulation; Humans; Hydrolysis; Phosphatidylinositols; | 1992 |
The disposition of TCNU (tauromustine) in human malignant glioma: pharmacokinetic studies and clinical implications.
Topics: Adult; Aged; Antineoplastic Agents; Astrocytoma; Brain; Brain Neoplasms; Female; Glioblastoma; Human | 1990 |
Experimental cerebral and plasma pharmacokinetic studies of TCNU: implications for brain tumour chemotherapy.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Glioma; Male; Nitrosourea Compounds; Rats; Rats, In | 1987 |
Amino acid uptake into human brain tumors.
Topics: Absorption; Alanine; Amino Acids; Aminobutyrates; Aspartic Acid; Astrocytoma; Autoradiography; Brain | 1974 |