tasiamide and Nasopharyngeal-Neoplasms

tasiamide has been researched along with Nasopharyngeal-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for tasiamide and Nasopharyngeal-Neoplasms

Article	Year
Design, synthesis and biological evaluation of tasiamide analogues as tumor inhibitors. Marine drugs, 2014, Apr-22, Volume: 12, Issue:4 Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus with aromatic groups were tolerated, with the IC₅₀ values between 1.29 and 12.88 μM against these two cancer cell lines. Truncation, minor modifications at the N-terminus or elimination of the N-methyl groups in N-Me-D-Gln and/or N-Me-D-Phe residues resulted in inactive analogues. Topics: Antineoplastic Agents; Carcinoma; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Inhibitory Concentration 50; Lung Neoplasms; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Oligopeptides; Structure-Activity Relationship	2014

Article

Year

Design, synthesis and biological evaluation of tasiamide analogues as tumor inhibitors.

Marine drugs, 2014, Apr-22, Volume: 12, Issue:4

Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus with aromatic groups were tolerated, with the IC₅₀ values between 1.29 and 12.88 μM against these two cancer cell lines. Truncation, minor modifications at the N-terminus or elimination of the N-methyl groups in N-Me-D-Gln and/or N-Me-D-Phe residues resulted in inactive analogues.

Topics: Antineoplastic Agents; Carcinoma; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Inhibitory Concentration 50; Lung Neoplasms; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Oligopeptides; Structure-Activity Relationship

2014