taprostene and Leukopenia

taprostene has been researched along with Leukopenia* in 3 studies

Other Studies

3 other study(ies) available for taprostene and Leukopenia

ArticleYear
Antithrombotic management with a stable prostacyclin analogue during extracorporeal circulation.
    Contributions to nephrology, 1991, Volume: 93

    Topics: Cellulose; Epoprostenol; Extracorporeal Circulation; Fibrinolytic Agents; Heparin; Humans; Leukopenia; Membranes, Artificial; Platelet Aggregation; Platelet Aggregation Inhibitors; Renal Dialysis; Thrombosis

1991
Pentoxifylline increases survival of mice in endotoxic shock.
    Progress in clinical and biological research, 1989, Volume: 301

    Topics: Animals; Epoprostenol; Female; Indomethacin; Leukopenia; Lipopolysaccharides; Mice; Pentoxifylline; Prostaglandins, Synthetic; Shock, Septic; Theobromine

1989
The role of prostacyclin in the protective effects of pentoxifylline and other xanthine derivatives in endotoxin action in mice.
    Eicosanoids, 1989, Volume: 2, Issue:3

    The xanthine derivative pentoxifylline (POF, Trental) and its metabolically more stable structural analogues, HWA 138 and HWA 448, were compared for their capacity to prevent leukopenia provoked in mice by injection of bacterial lipopolysaccharide (LPS). It was found that HWA 138 and HWA 448 counteracted LPS-induced leukopenia more effectively than POF. Indomethacin diminished the action of HWA 138 and HWA 448, and the stable prostacyclin analogue CG-4203 (Taprosten) mimicked the effect of the xanthine derivatives. Since pentoxifylline and its structural analogues induced synthesis of PGI2 in endothelial cell cultures, it is suggested that its effect on LPS leukopenia is mediated by endogenous prostacyclin production. All of the xanthine derivatives tested and CG-4203 blocked the leukopenia induced by recombinant tumor necrosis factor, which is a major endogenous mediator for endotoxin toxicity.

    Topics: Animals; Endotoxins; Epoprostenol; Female; Indomethacin; Leukopenia; Lipopolysaccharides; Mice; Pentoxifylline; Theobromine; Tumor Necrosis Factor-alpha

1989