tanshinone has been researched along with Innate Inflammatory Response in 56 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (3.57) | 29.6817 |
| 2010's | 29 (51.79) | 24.3611 |
| 2020's | 25 (44.64) | 2.80 |
| Authors | Studies |
|---|---|
| Edwards, BS; Graves, SW; Saunders, MJ; Sklar, LA; Zhu, J | 1 |
| Fan, J; Feng, XY; Pu, J; Shang, Y; Xu, JW; Zhang, R; Zhao, JY | 1 |
| Li, P; Liu, J; Wu, YH; Zhang, ZL | 1 |
| Deng, X; Li, Y; Lv, X; Xue, H; Zhu, S; Zhuang, W | 1 |
| Ahn, J; Callaway, TR; Duberstein, KJ; Fagan, MM; Jeon, JH; Kaiser, EE; Kinder, HA; Kumar, A; Lourenco, JM; Park, HJ; Platt, SR; Rothrock, MJ; Scheulin, KM; Shin, SK; Sneed, SE; Waters, ES; West, FD; Xie, J; Yang, X | 1 |
| Chen, J; Chen, Y; Hu, C; Li, W; Liang, G; Luo, W; Lv, X; Ren, M; Shao, J; Xiao, Z; Xu, H; Xu, X | 1 |
| Mehan, S; Sherawat, K | 1 |
| Chi, MC; Chiang, YC; Fang, ML; Huang, CC; Lee, CW; Lee, HC; Lin, CM; Lin, ZC; Peng, KT | 1 |
| Calabriso, N; Carluccio, MA; Carpi, S; Cecchini, M; Doccini, S; Maione, F; Marigliano, N; Massaro, M; Nieri, P; Polini, B; Quarta, S; Santorelli, FM; Saviano, A; Scoditti, E; Wabitsch, M | 1 |
| Gao, F; Jia, W; Li, C; Ma, X; Zhang, L | 1 |
| Cai, K; Duan, JA; Liu, F; Su, SL; Xu, Z; Zhu, Y | 1 |
| Fan, L; Li, Q; Liu, Q; Wang, X; Yuan, L; Zhang, Z | 1 |
| Cheng, D; Kong, AN; Li, S; Li, W; Sargsyan, D; Wang, L; Wu, R | 1 |
| Fan, G; Gao, S; Guo, R; Li, L; Mao, J; Ni, J | 1 |
| Cui, Z; Ding, X; Fan, J; Liu, W; Sun, Y; Wang, X | 1 |
| Chen, S; Chen, T; Cui, S; Li, S; Wu, Q | 1 |
| Qian, J; Yu, L | 1 |
| Cong, P; Hou, M; Jin, H; Li, J; Liu, Y; Shi, L; Shi, X; Tang, Y; Tong, C; Zhao, Y | 1 |
| Chen, JM; Liang, BY; Liao, YJ; Long, JY; Zhou, Y; Zhou, YJ | 1 |
| Chen, W; Guo, S; Li, X; Song, N; Wang, D; Yu, R | 1 |
| He, Y; Jin, H; Peng, X; Ruganzu, JB; Yang, W | 1 |
| Foulkes, MJ; Henry, KM; Jones, S; Renshaw, SA; Tolliday, FH | 1 |
| Huang, F; Li, N; Li, XN; Liu, BL; Liu, QY; Niu, Q; Qiu, ZX; Song, XR; Sun, QS; Zhuang, Y | 1 |
| Guo, YX; Li, LH; Li, WY; Liu, D; Lu, XL; Luo, WB; Tan, LM; Tang, Z; Xiong, H; Zhou, B; Zhu, LG | 1 |
| Feng, J; He, Y; Liu, L; Wang, J; Yao, F; Zhou, D | 1 |
| Huang, Q; Liu, J; Song, J; Wei, F; Yang, L; Zhang, Z; Zhou, G | 1 |
| Feng, C; Gu, H; Han, S; Li, D; Li, L; Li, Q; Li, S; Liu, M; Xu, G; Zheng, B | 1 |
| Ding, X; Guo, M; Liu, Z; Lv, J; Shi, J; Wang, J; Wang, X; Xu, C; Zhang, K | 1 |
| Chen, H; Deng, W; Hu, W; Hua, L; Liang, S; Ou, Y; Sun, P; Yang, Z; Yue, H; Zhang, C | 1 |
| Chen, X; Dai, D; Gao, Y; Ge, S; Kong, Y; Liu, Q; Lu, Z; Sun, D; Wang, F; Wang, N; Wu, R; Yang, Y | 1 |
| Jia, PT; Li, L; Lu, X; Zhang, XL; Zuo, HN | 1 |
| Cao, YA; Peng, CS; Tian, L; Xia, J; Yang, L; Zhang, WL | 1 |
| Liang, Z; Luan, L | 1 |
| Liu, X; Meng, J | 1 |
| Fan, G; Gao, S; Guo, Y; Li, D; Mao, J; Wang, Y; Xu, S; Zhu, M | 1 |
| Li, Y; Zhou, Y | 1 |
| A, S; Chen, J; Fan, G; Gao, X; Han, X; Jia, H; Li, M; Liang, W; Liu, W; Mao, J; Shang, Y; Tan, B; Wang, W; Xu, Q; Zhang, J; Zou, Y | 1 |
| Li, HY; Meng, Z; Si, CY; Teng, S; Yu, XH | 1 |
| Gong, X; Jiang, H; Li, Z; Lu, W; Wang, J; Wang, S; Xu, X; Zhang, C; Zhang, K | 1 |
| Hoodless, LJ; Lucas, CD; Rossi, AG | 1 |
| Anderson, SR; Bojarczuk, AN; Burgon, J; Chimen, M; Coles, MC; Farrow, SN; Hamza, B; Holmes, GR; Irimia, D; Jones, S; Kadirkamanathan, V; Loynes, CA; Prince, LR; Rainger, GE; Renshaw, SA; Robertson, AL; Sawtell, AK; Solari, R; Walmsley, SR; Whyte, MK; Willson, J | 1 |
| Li, C; Li, Y; Li, Z; Liu, M; Sun, X; Wang, Y; Wu, H; Xu, D | 1 |
| An, XJ; Cao, FL; Jiang, XL; Liu, XZ; Shan, L; Wang, XY; Xu, M; Xu, W; Zhang, YF | 1 |
| Feng, Z; Gao, L; He, H; Lin, H; Tang, H; Wu, T; Wu, Y | 1 |
| Gu, A; Hu, H; Jin, D; Liu, J; Qian, G; Tang, G; Wang, H; Xu, W; Ying, F; Zhai, C; Zhang, Y | 1 |
| Fan, G; Fordjour, PA; Gao, X; Jiang, X; Miao, L; Wu, X; Zhang, H; Zhu, Y | 1 |
| An, G; He, H; Huang, T; Lei, Z; Liu, F; Liu, X; Wen, T | 1 |
| Hu, XR; Huang, DD; Hung, ZA; Shu, M; Zhang, S | 1 |
| Huang, D; Li, C; Liang, A; Peng, Y; Sun, J; Wang, X; Xu, K; Ye, W | 1 |
| Chen, GY; Chuang, DY; Shu, YC; Wang, YC | 1 |
| Ha, H; Kim, HH; Kim, HN; Kwak, HB; Lee, JH; Lee, ZH; Shin, HI; Sun, HM | 1 |
| Chen, Y; Ma, J; Ren, ZH; Tong, YH; Xu, W | 1 |
| Dong, J; Dong, X; Fan, L; Liu, L; Wu, G; Zhang, R | 1 |
| Cao, FL; Chen, YF; Hou, WG; Luo, ZJ; Peng, Y; Sun, SK; Yin, X; Yin, Y | 1 |
| Brakebusch, C; Pedersen, E; Peyrollier, K; Quondamatteo, F; Rösner, LM; Stanley, A; Wang, Z; Werfel, T | 1 |
| Guo, L; Guo, Y; Tang, F; Tu, J; Xi, T; Xing, Y | 1 |
2 review(s) available for tanshinone and Innate Inflammatory Response
| Article | Year |
|---|---|
Tanshinone-IIA mediated neuroprotection by modulating neuronal pathways.
Topics: Abietanes; Anti-Inflammatory Agents; Apoptosis; Humans; Inflammation; Neuroprotection | 2023 |
The protective effect of tanshinone IIa on endothelial cells: a generalist among clinical therapeutics.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Endothelial Cells; Humans; Inflammation; Oxidative Stress; Salvia miltiorrhiza | 2021 |
1 trial(s) available for tanshinone and Innate Inflammatory Response
| Article | Year |
|---|---|
Tanshinone I and Tanshinone IIA/B attenuate LPS-induced mastitis via regulating the NF-κB.
Topics: Abietanes; Adult; Animals; Anti-Infective Agents; Apoptosis; Breast Feeding; Cefprozil; Cephalosporins; Disease Models, Animal; Drug Therapy, Combination; Female; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Mammary Glands, Animal; Mammary Glands, Human; Mastitis; Mice, Inbred BALB C; NF-kappa B p50 Subunit; Peroxidase; Tumor Necrosis Factor-alpha; Ultrasonography, Mammary | 2021 |
53 other study(ies) available for tanshinone and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Inflammation; Kinetics; Microspheres; Peptide Hydrolases; Peptides; Reproducibility of Results; Temperature | 2010 |
Tanshinone IIA prevents acute lung injury by regulating macrophage polarization.
Topics: Abietanes; Acute Lung Injury; Animals; Cytokine Release Syndrome; Cytokines; Inflammation; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice | 2022 |
Tanshinone IIA improves sepsis-induced acute lung injury through the ROCK2/NF-κB axis.
Topics: Abietanes; Acute Lung Injury; Animals; Inflammation; Lipopolysaccharides; Lung; NF-kappa B; Rats; rho-Associated Kinases; Sepsis | 2022 |
Tanshinone IIA down-regulates -transforming growth factor beta 1 to relieve renal tubular epithelial cell inflammation and pyroptosis caused by high glucose.
Topics: Abietanes; Epithelial Cells; Glucose; Humans; Inflammation; Pyroptosis | 2022 |
Tanshinone IIA-loaded nanoparticles and neural stem cell combination therapy improves gut homeostasis and recovery in a pig ischemic stroke model.
Topics: Animals; Fatty Acids, Volatile; Inflammation; Ischemic Stroke; Male; Nanoparticles; Neural Stem Cells; Stroke; Swine; Tumor Necrosis Factor-alpha | 2023 |
Tanshinone IIA analogue 15a inhibits NLRP3-mediated inflammation by activating mitophagy in macrophages to alleviate acute tubular necrosis.
Topics: Animals; Inflammasomes; Inflammation; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitophagy; Necrosis; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species | 2023 |
Tanshinone IIA suppresses burning incense-induced oxidative stress and inflammatory pathways in astrocytes.
Topics: Abietanes; Animals; Astrocytes; Humans; Inflammation; Oxidative Stress; Rats | 2023 |
Tanshinone IIA and Cryptotanshinone Counteract Inflammation by Regulating Gene and miRNA Expression in Human SGBS Adipocytes.
Topics: Adipocytes; Chemokine CCL5; Chemokine CXCL10; Humans; Inflammation; Interleukin-8; MicroRNAs; Tumor Necrosis Factor-alpha | 2023 |
Salvia miltiorrhiza and Tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation through inhibiting COX-2.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cyclooxygenase 2; Inflammation; Mice; Molecular Docking Simulation; NF-kappa B; Plaque, Atherosclerotic; Salvia miltiorrhiza | 2023 |
Salvianolic acid B and tanshinone IIA synergistically improve early diabetic nephropathy through regulating PI3K/Akt/NF-κB signaling pathway.
Topics: Animals; Diabetes Mellitus; Diabetic Nephropathies; Glucose; Inflammation; Nephritis; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction | 2024 |
Tanshinone IIA inhibits the adipogenesis and inflammatory response in ox-LDL-challenged human monocyte-derived macrophages via regulating miR-130b/WNT5A.
Topics: Abietanes; Adipogenesis; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Atherosclerosis; Gene Expression Regulation; Humans; Inflammation; Lipoproteins, LDL; Macrophages; MicroRNAs; Wnt-5a Protein | 2020 |
DNA Methylome and Transcriptome Alterations in High Glucose-Induced Diabetic Nephropathy Cellular Model and Identification of Novel Targets for Treatment by Tanshinone IIA.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Diabetic Nephropathies; Disease Models, Animal; DNA Methylation; Glucose; Inflammation; Mice; Molecular Structure; Oxidative Stress; Transcriptome | 2019 |
Effects of the combination of tanshinone IIA and puerarin on cardiac function and inflammatory response in myocardial ischemia mice.
Topics: Abietanes; Animals; CD11 Antigens; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Heart; Heart Function Tests; Heart Ventricles; Hemodynamics; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Isoflavones; Macrophages; Mice; Monocytes; Myocardial Ischemia; Myocardium; RAW 264.7 Cells; Signal Transduction; Ventricular Remodeling | 2019 |
Tanshinone I Inhibits IL-1β-Induced Apoptosis, Inflammation And Extracellular Matrix Degradation In Chondrocytes CHON-001 Cells And Attenuates Murine Osteoarthritis.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Survival; Cells, Cultured; Chondrocytes; Extracellular Matrix; Female; Inflammation; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Osteoarthritis | 2019 |
A network pharmacology approach to investigate the anti-inflammatory mechanism of effective ingredients from Salvia miltiorrhiza.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Drugs, Chinese Herbal; Humans; Inflammation; Lipopolysaccharides; Macrophage Activation; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Phenanthrenes; Protein Interaction Mapping; Protein Interaction Maps; RAW 264.7 Cells; Salvia miltiorrhiza; Signal Transduction; Toll-Like Receptors | 2020 |
Dihydrotanshinone I Alleviates Spinal Cord Injury via Suppressing Inflammatory Response, Oxidative Stress and Apoptosis in Rats.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Apoptosis; HMGB1 Protein; Inflammation; Interleukin-6; NADPH Oxidase 4; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Recovery of Function; Signal Transduction; Spinal Cord Injuries; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2020 |
Tanshinone IIA alleviates blast-induced inflammation, oxidative stress and apoptosis in mice partly by inhibiting the PI3K/Akt/FoxO1 signaling pathway.
Topics: Abietanes; Animals; Apoptosis; Forkhead Box Protein O1; Inflammation; Mice; Mice, Inbred C57BL; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2020 |
Tanshinone IIA Alleviates CCL2-Induced Leaning memory and Cognition Impairment in Rats: A Potential Therapeutic Approach for HIV-Associated Neurocognitive Disorder.
Topics: Abietanes; Animals; Apoptosis; Apoptosis Regulatory Proteins; Chemokine CCL2; Cognition; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; HIV Infections; In Situ Nick-End Labeling; Inflammation; Male; Memory; Memory Disorders; Rats; Rats, Sprague-Dawley | 2020 |
The regulated profile of noncoding RNAs associated with inflammation by tanshinone IIA on atherosclerosis.
Topics: Abietanes; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cholesterol; Disease Models, Animal; Gene Expression Regulation; Gene Ontology; Genes, Reporter; Inflammation; Male; Mice; Mice, Inbred C57BL; MicroRNAs; RAW 264.7 Cells; Reproducibility of Results; RNA, Circular; RNA, Long Noncoding; Triglycerides | 2020 |
Tanshinone IIA suppresses lipopolysaccharide-induced neuroinflammatory responses through NF-κB/MAPKs signaling pathways in human U87 astrocytoma cells.
Topics: Abietanes; Astrocytes; Cell Line, Tumor; Humans; Inflammation; Interleukin-6; Lipopolysaccharides; MAP Kinase Signaling System; NF-kappa B; Phosphorylation; Tumor Necrosis Factor-alpha | 2020 |
Evaluation of the anti-inflammatory effects of synthesised tanshinone I and isotanshinone I analogues in zebrafish.
Topics: Abietanes; Animals; Animals, Genetically Modified; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Humans; Inflammation; Molecular Structure; Naphthoquinones; Neutrophil Infiltration; Zebrafish | 2020 |
Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages.
Topics: Abietanes; Acetylation; Animals; Anti-Inflammatory Agents; Enzyme Inhibitors; Glycolysis; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammasomes; Inflammation; Lipopolysaccharides; Macrophages; Male; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; Sirtuin 2; Succinate Dehydrogenase; Tubulin | 2021 |
Tanshinone IIA Ameliorates Inflammation Response in Osteoarthritis via Inhibition of miR-155/FOXO3 Axis.
Topics: 3' Untranslated Regions; Abietanes; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Survival; Chondrocytes; Forkhead Box Protein O3; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; MicroRNAs; Osteoarthritis; Primary Cell Culture; Tumor Necrosis Factor-alpha | 2021 |
Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in Inflammatory Response by Promoting Classical Macrophage Activation.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Abietanes; Animals; Antibodies, Neutralizing; Benzaldehydes; Case-Control Studies; Cell Cycle Proteins; Cell Polarity; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Knockout Techniques; Humans; Inflammation; Macrophage Activation; Macrophages; Male; Monocytes; Multiple Sclerosis; Oximes; Phospholipases A2, Secretory; Rats; Rats, Transgenic; Receptors, G-Protein-Coupled; Signal Transduction; Treatment Outcome | 2021 |
Inhibition of ASC enhances the protective role of salvianolic acid A in traumatic brain injury via inhibition of inflammation and recovery of mitochondrial function.
Topics: Abietanes; Animals; Brain Injuries, Traumatic; Caffeic Acids; Calcium; CARD Signaling Adaptor Proteins; Cell Line; Cell Proliferation; Cytokines; HEK293 Cells; Humans; Inflammation; Lactates; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Mitochondria; Neuroprotective Agents; Reactive Oxygen Species; Signal Transduction | 2021 |
Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation.
Topics: Abietanes; AMP-Activated Protein Kinases; Animals; Autophagy; Disease Models, Animal; Female; Furans; Gout; Humans; Inflammasomes; Inflammation; Male; Mice; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Phenanthrenes; Quinones; Rats; Reactive Oxygen Species; Shock, Septic; Uric Acid | 2021 |
Tanshinone IIA attenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation.
Topics: Abietanes; Albuminuria; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Inflammation; Inflammation Mediators; Kidney Function Tests; Male; Oxidative Stress; Rats | 2017 |
Articular cartilage degradation is prevented by tanshinone IIA through inhibiting apoptosis and the expression of inflammatory cytokines.
Topics: Abietanes; Animals; Anterior Cruciate Ligament; Apoptosis; Bone Morphogenetic Proteins; Cartilage, Articular; Chondrocytes; Cytokines; Disease Models, Animal; Inflammation; Interleukin-1beta; Male; Menisci, Tibial; Nitric Oxide; Osteoarthritis; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2017 |
Neuroprotective effect of tanshinone IIA weakens spastic cerebral palsy through inflammation, p38MAPK and VEGF in neonatal rats.
Topics: Abietanes; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Palsy; Inflammation; Male; Neuroprotective Agents; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2018 |
Tanshinone IIA protects murine chondrogenic ATDC5 cells from lipopolysaccharide-induced inflammatory injury by down-regulating microRNA-203a.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Chondrogenesis; Down-Regulation; Inflammation; Lipopolysaccharides; Mice; MicroRNAs | 2018 |
RETRACTED: Tanshinone IIA ameliorates lipopolysaccharide-induced inflammatory response in bronchial epithelium cell line BEAS-2B by down-regulating miR-27a.
Topics: Abietanes; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Proteins; Bronchi; Cell Line; Cell Survival; Down-Regulation; Humans; Inflammation; Interleukin-1beta; Lipopolysaccharides; MAP Kinase Signaling System; MicroRNAs; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Respiratory Mucosa; Signal Transduction; Tumor Necrosis Factor-alpha | 2018 |
TanshinoneIIA Alleviates Inflammatory Response and Directs Macrophage Polarization in Lipopolysaccharide-Stimulated RAW264.7 Cells.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Inflammation; Lipopolysaccharides; Macrophages; Mice; Mitochondria; RAW 264.7 Cells; Toll-Like Receptor 4 | 2019 |
The therapeutic effect of tanshinone IIA on Propionibacterium acnes-induced inflammation in vitro.
Topics: Abietanes; Acne Vulgaris; Anti-Bacterial Agents; Anti-Inflammatory Agents; Cytokines; Host-Pathogen Interactions; Humans; Inflammation; Inflammation Mediators; Intercellular Adhesion Molecule-1; Monocytes; NF-kappa B; Propionibacterium acnes; Signal Transduction; THP-1 Cells; Toll-Like Receptor 2 | 2018 |
Rebuilding Postinfarcted Cardiac Functions by Injecting TIIA@PDA Nanoparticle-Cross-linked ROS-Sensitive Hydrogels.
Topics: Abietanes; Animals; Heart; Humans; Hyaluronic Acid; Hydrogels; Indoles; Inflammation; Interleukin-1beta; Interleukin-6; Magnetic Resonance Imaging; Myocardial Infarction; Nanoparticles; Polymers; Rabbits; Reactive Oxygen Species; Tissue Engineering; Tumor Necrosis Factor-alpha | 2019 |
Tanshinone IIA inhibits lipopolysaccharide‑induced inflammatory responses through the TLR4/TAK1/NF‑κB signaling pathway in vascular smooth muscle cells.
Topics: Abietanes; Animals; Cell Death; Chemokine CCL2; Down-Regulation; Inflammation; Interleukin-6; Lipopolysaccharides; Male; MAP Kinase Kinase Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phenotype; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2019 |
Tanshinone IIA inhibits lipopolysaccharide-induced MUC1 overexpression in alveolar epithelial cells.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Gene Expression Regulation; Humans; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucin-1; Pulmonary Alveoli; Random Allocation; Respiratory Mucosa | 2014 |
Swimming against the tide: drugs drive neutrophil reverse migration.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Cell Movement; High-Throughput Screening Assays; Humans; Inflammation; Neutrophil Infiltration; Neutrophils; Zebrafish | 2014 |
A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.
Topics: Abietanes; Animals; Animals, Genetically Modified; Anti-Inflammatory Agents; Apoptosis; Cell Movement; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Inflammation; Larva; Neutrophil Infiltration; Neutrophils; Signal Transduction; Time Factors; Translational Research, Biomedical; Zebrafish | 2014 |
Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis via modulating angiotensin-converting enzyme 2/ angiotensin-(1-7) axis in rats.
Topics: Abietanes; Angiotensin I; Angiotensin-Converting Enzyme 2; Animals; Bleomycin; Humans; Inflammation; Peptide Fragments; Peptidyl-Dipeptidase A; Pulmonary Fibrosis; Rats; Transforming Growth Factor beta | 2014 |
Tanshinone IIA therapeutically reduces LPS-induced acute lung injury by inhibiting inflammation and apoptosis in mice.
Topics: Abietanes; Acute Lung Injury; Animals; Apoptosis; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C | 2015 |
Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats.
Topics: Abietanes; Animals; Antibiotics, Antineoplastic; Bleomycin; Bronchoalveolar Lavage Fluid; Cell Count; Cyclooxygenase 2; Disease Models, Animal; Drugs, Chinese Herbal; Inflammation; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Pulmonary Fibrosis; Rats | 2015 |
Protective effects of tanshinone IIA on myocardial ischemia reperfusion injury by reducing oxidative stress, HMGB1 expression, and inflammatory reaction.
Topics: Abietanes; Animals; Cardiotonic Agents; Drugs, Chinese Herbal; Gene Expression Regulation; HMGB1 Protein; Inflammation; Male; Myocardial Reperfusion Injury; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2015 |
Anti-Inflammatory Activity of Tanshinone IIA in LPS-Stimulated RAW264.7 Macrophages via miRNAs and TLR4-NF-κB Pathway.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Cell Line; Cytokines; Drugs, Chinese Herbal; Gene Expression; HeLa Cells; Humans; Inflammation; Lipopolysaccharides; Macrophages; Mice; MicroRNAs; Myeloid Differentiation Factor 88; NF-kappa B; Signal Transduction; Toll-Like Receptor 4 | 2016 |
Tanshinone IIA Protects against Dextran Sulfate Sodium- (DSS-) Induced Colitis in Mice by Modulation of Neutrophil Infiltration and Activation.
Topics: Abietanes; Animals; Anti-Infective Agents; Cell Movement; Colitis; Colon; Dextran Sulfate; Drugs, Chinese Herbal; Inflammation; Intestinal Mucosa; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Neutrophil Activation; Neutrophil Infiltration; Neutrophils; Permeability; Reactive Oxygen Species | 2016 |
Effects of tanshinone IIA on fibrosis in a rat model of cirrhosis through heme oxygenase-1, inflammation, oxidative stress and apoptosis.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Biomarkers; Cytokines; Disease Models, Animal; Fibrosis; Heme Oxygenase-1; Inflammation; Inflammation Mediators; Male; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Rats | 2016 |
Regulation of a disintegrins and metalloproteinase with thrombospondin motifs 7 during inflammation in nucleus pulposus (NP) cells: role of AP-1, Sp1 and NF-κB signaling.
Topics: Abietanes; ADAMTS7 Protein; Animals; Benzamides; HEK293 Cells; Humans; Inflammation; NF-kappa B; Nucleus Pulposus; Rats; Sp1 Transcription Factor; Thiazoles; Transcription Factor AP-1 | 2016 |
Inflammatory and Apoptotic Regulatory Activity of Tanshinone IIA in Helicobacter pylori-Infected Cells.
Topics: Abietanes; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 9; Cell Line, Tumor; Gene Expression; Helicobacter pylori; Humans; Inflammation; Inflammation Mediators; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Phytotherapy; RAW 264.7 Cells; Salvia miltiorrhiza; Signal Transduction; Stomach Neoplasms | 2016 |
Tanshinone IIA suppresses inflammatory bone loss by inhibiting the synthesis of prostaglandin E2 in osteoblasts.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Diseases; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Regulation; Inflammation; Male; Mice; Mice, Inbred ICR; Osteoblasts; Osteoclasts; Phenanthrenes | 2008 |
Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Chemokine CCL2; Coronary Vessels; Disease Models, Animal; Drugs, Chinese Herbal; Fibroblasts; Heart; Inflammation; Macrophages; Male; Myocardial Infarction; Myocardium; Myocytes, Cardiac; NF-kappa B; Phenanthrenes; Phytotherapy; Plant Roots; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2010 |
Anti-inflammatory effects of tanshinone IIA on radiation-induced microglia BV-2 cells inflammatory response.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Cell Survival; Cells, Cultured; DNA Primers; Inflammation; Mice; Microglia; Phenanthrenes; Polymerase Chain Reaction; Radionuclide Imaging; Radiotherapy; RNA | 2009 |
Tanshinone IIA attenuates the inflammatory response and apoptosis after traumatic injury of the spinal cord in adult rats.
Topics: Abietanes; Aging; Animals; Apoptosis; Astrocytes; Biomarkers; Cytokines; Inflammation; Inflammation Mediators; Male; MAP Kinase Signaling System; Neutrophil Infiltration; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Wounds and Injuries | 2012 |
RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1.
Topics: Abietanes; Actin Cytoskeleton; Actin-Related Protein 2-3 Complex; Actins; Animals; Cell Differentiation; Enzyme Activation; Epidermis; Gene Expression Regulation; Inflammation; Interferon-gamma; Keratinocytes; Leukocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuropeptides; Polymerization; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Signal Transduction; Skin; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate | 2012 |
TanshinoneIIA ameliorates inflammatory microenvironment of colon cancer cells via repression of microRNA-155.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Gene Expression Regulation; Humans; Inflammation; Inositol Polyphosphate 5-Phosphatases; Lipopolysaccharides; Macrophages; Mice; MicroRNAs; Molecular Structure; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; RNA, Messenger | 2012 |