tanshinone has been researched along with Disease Models, Animal in 117 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (8.55) | 29.6817 |
| 2010's | 79 (67.52) | 24.3611 |
| 2020's | 28 (23.93) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Hua, FY; Huang, XT; Liu, NZ; Mei, WJ; Shu, J; Wang, R; Wang, T; Wang, XC; Wu, Q; Yuan, CL; Zhai, BB; Zou, J | 1 |
| Dai, S; Li, S; Li, Z; Tan, T; Wu, Y; Xu, F | 1 |
| Ba, Z; He, Y; Huang, J; Huang, N; Li, Y; Liu, D; Luo, Y; Shi, S; Yang, X; You, C; Yu, C | 1 |
| Chen, L; Guo, H; He, Y; Ji, S; Peng, X; Ruganzu, JB; Wang, Z; Yang, W; Zhang, X; Zheng, L | 1 |
| Chen, H; Chen, Q; Dai, M; Li, Y; Liu, H; Shao, L; Xiang, N | 1 |
| Huang, D; Wu, M; Yang, F; Ye, C | 1 |
| Wang, X; Wu, C | 1 |
| Chen, LL; Lin, L; Liu, SZ; Wang, P; Yang, J | 1 |
| Bai, Z; Fang, Z; Hong, Z; Hou, X; Liu, H; Liu, T; Luo, W; Mu, W; Ren, L; Shi, W; Wei, Z; Wen, J; Xiao, X; Xu, G; Yang, Y; Zhan, X; Zhao, J; Zou, W | 1 |
| Cheng, D; Kong, AN; Li, S; Li, W; Sargsyan, D; Wang, L; Wu, R | 1 |
| Li, X; Li, Y; Shu, Y; Xiang, D; Zeng, X | 1 |
| Fan, G; Gao, S; Guo, R; Li, L; Mao, J; Ni, J | 1 |
| Hu, F; Jiang, Y; Li, M; Li, Q; Shen, C; Yang, J | 1 |
| Chen, W; Guo, J; He, X; Jia, L; Liu, J; Sun, H; Wang, J; Yang, G; Zhang, L; Zhang, N | 1 |
| Cheng, P; Feng, F; Li, N; Qi, Y; Wang, H; Wang, W; Wang, Y; Zhang, H | 1 |
| Lu, J; Meng, D; Miao, Z; Pan, K; Wan, B; Zhang, J; Zhou, H | 1 |
| Chen, JM; Liang, BY; Liao, YJ; Long, JY; Zhou, Y; Zhou, YJ | 1 |
| Bi, F; Tie, M; Wang, K; Zhang, Y | 1 |
| Chen, L; Liu, G; Shi, H; Wei, L; Yu, Q | 1 |
| Chen, W; Gong, W; Huang, W; Li, W; Lu, G; Lu, Y; Ma, X; Xia, Q; Xiao, W; Yuan, C; Zhu, Q | 1 |
| Chen, W; Guo, S; Li, X; Song, N; Wang, D; Yu, R | 1 |
| Cui, LJ; Ding, XL; Fu, Y; Gong, Y; Liu, YC; Lv, AW; Song, HH; Tian, LL; Wang, Z; Yan, YP; Zhang, YL; Zhu, WL | 1 |
| Tong, H; Wang, J; Wang, X; Wang, Y | 1 |
| Han, Y; Jia, L; Liu, Y; Ni, G; Wang, J; Wang, Y | 1 |
| An, L; Chen, J; Li, P; Zhang, P; Zhang, XW; Zhou, M | 1 |
| Chen, S; Hou, Y; Li, X; Lin, D; Luan, J; Luo, D; Wang, L; Zhan, J | 1 |
| Chen, H; Gao, Y; Ji, X; Jin, S; Li, N; Lin, Q; Liu, Y; Xu, W; Yang, N; Zhang, S | 1 |
| Huang, Z; Kong, D; Luo, J; Shi, S | 1 |
| Huang, Q; Liu, J; Song, J; Wei, F; Yang, L; Zhang, Z; Zhou, G | 1 |
| Jiang, Y; Liu, J; Sheng, P; Wang, F; Xia, Z; Yan, BC | 1 |
| Gong, C; Hu, D; Ng, W; Ni, Z; Si, G; Sun, Y; Wang, L; Yan, X; Yao, C; Zhao, C; Zhu, S; Zhu, X | 1 |
| Chen, H; Deng, W; Hu, W; Hua, L; Liang, S; Ou, Y; Sun, P; Yang, Z; Yue, H; Zhang, C | 1 |
| Du, J; Feng, J; Hu, K; Liu, M; Wang, L; Xu, L; Zhao, X | 1 |
| Pan, GQ; Pan, XD; Sun, LF; Tang, LM; Wang, LX; Wang, ZY | 1 |
| Jia, PT; Li, L; Lu, X; Zhang, XL; Zuo, HN | 1 |
| Chang, TW; Chen, EL; Chen, MH; Chen, TI; Chiang, YC; Jhang, YS; Lai, SC; Lin, CY; Lin, IH; Seenan, V; Shiung, J; Tseng, YW; Tzeng, YJ | 1 |
| Han, XR; Li, L; Lu, J; Wang, YJ; Wen, X; Wu, DM; Xu, L; Zheng, YL | 1 |
| Bi, Y; Chen, J; Chen, L; Xu, L; Zhang, Q | 1 |
| Ding, F; Feng, J; Feng, Y; Gao, H; Huang, L; Tang, H; Xu, QM; Yang, K; Yang, S | 1 |
| Fu, J; Jiao, ZM; Li, JY; Ma, J; Sun, Y; Wang, D; Yu, BQ; Yu, MY; Zhang, XM | 1 |
| Fu, Z; Liu, F; Ni, Q; Wang, Q; Wang, Y; Ye, Q | 1 |
| Chen, J; Li, Z; Liu, M; Niu, W; Sun, X; Wang, Y; Wu, H | 1 |
| Chen, P; Guo, R; Lan, Y; Mao, S; Wang, L; Zhang, M | 1 |
| Gong, G; Gu, Y; Li, J; Li, L; Liu, W; Zhang, Y | 1 |
| Heo, JY; Im, DS | 1 |
| Guo, G; Li, E; Wang, Q; Zhao, Q | 1 |
| Gao, M; Jiang, Y; Ou, H; Peng, Y; Wang, K; Xiao, X; Yang, M; Zhang, H | 1 |
| Ba, Z; Feng, F; Huang, N; Li, Y; Luo, Y; Shi, S; Zhou, Y | 1 |
| Chen, W; Guo, S; Jia, L; Li, X; Song, N; Wang, J; Zhu, A | 1 |
| Ai-Hua, T; Jadoon, SS; Li, F; Lin, L; Liu, SZ; Wang, P; You, QY; Zhang, MY; Zhang, RY | 1 |
| Dai, X; Liang, S; Qin, F; Sun, Y; Wang, Z; Yuan, J; Zhang, J | 1 |
| Huang, LH; Li, WW; Wang, F; Wen, PY; Yang, FZ; Zhou, J; Zhou, L | 1 |
| Buenafe, OE; Crawford, AD; De Borggraeve, W; de Witte, P; Esguerra, CV; Huang, H; Luyten, W; Maes, J; Orellana-Paucar, A; Ying, X | 1 |
| Chen, SP; Chiu, SC; Chiu, TL; Huang, SY; Pang, CY; Su, CC | 1 |
| Liu, CJ; Liu, Z; Qiao, Q; Ran, F; Shang, T | 1 |
| Li, W; Luo, H; Song, Z; Wen, P; Zhou, J; Zhou, L | 1 |
| Anderson, SR; Bojarczuk, AN; Burgon, J; Chimen, M; Coles, MC; Farrow, SN; Hamza, B; Holmes, GR; Irimia, D; Jones, S; Kadirkamanathan, V; Loynes, CA; Prince, LR; Rainger, GE; Renshaw, SA; Robertson, AL; Sawtell, AK; Solari, R; Walmsley, SR; Whyte, MK; Willson, J | 1 |
| Chen, J; Chen, S; Huang, H; Huang, Y; Liu, P; Liu, Z; Shen, X; Xu, S | 1 |
| Jiang, P; Jiao, B; Li, C; Xiang, Z | 1 |
| Li, SX; Luo, K; Peng, MJ; Wang, YQ; Xie, Y; Xu, F; Yan, JY | 1 |
| Dong, H; Dong, M; Li, Z; Liu, M; Liu, Y; Luo, Y; Niu, W; Wei, M; Yan, Z; Zhao, P; Zheng, L | 1 |
| Cao, FL; Gong, KR; Wang, Y; Xu, M; Zhang, JT | 1 |
| Ren, B; Si, DW; Sun, FW; Wei, Z; Zhang, CY; Zhang, YX; Zhang, ZF; Zhou, HX | 1 |
| Chen, H; Pang, LX; Shen, Y; Sun, RH; Tu, JF; Yang, XH; Zhang, MQ; Zheng, YL | 1 |
| Bondy, SC; Jian, L; Li, W; Luo, H; Wen, P; Yang, F; Zhou, J; Zhou, L | 1 |
| Li, H; Li, P; Li, S; Shi, Q; Yang, F; Zhao, L | 1 |
| Chai, L; Guo, H; Hu, L; Jing, H; Liu, Z; Wang, S; Yang, H | 1 |
| Feng, Z; Gao, L; He, H; Lin, H; Tang, H; Wu, T; Wu, Y | 1 |
| Cheng, X; Huang, RH; Lin, X; Wang, DT; Yang, YJ; Zhang, ZH | 1 |
| Guo, CY; Liu, X; Ma, XJ; Pan, YT; Sun, MY; Wu, CF; Yin, HJ; Zhang, Y | 1 |
| Hui, X; Ji, Y; Ren, BX; Sun, DP; Tang, JC; Yang, DQ; Zhu, XL | 1 |
| Li, WY; Li, ZH; Liu, XY; Luo, ZJ; Sun, SK; Tang, J; Zhang, H; Zhang, T; Zhu, C | 1 |
| Ren, Y; Wang, Z; Wu, R; Wu, T; Xia, T | 1 |
| Li, J; Li, ZH; Liu, JP; Yan, HX; Zhang, WL | 1 |
| Duan, SS; Ha, S; Li, ZA; Shi, YL; Wang, XL; Zhang, XS | 1 |
| Li, J; Li, WW; Wen, PY; Zhou, J | 1 |
| Feng, F; Feng, Y; Li, WH; Liu, Z; Lv, Z; Wang, WC; Wu, ZD | 1 |
| Fei, Y; Hu, X; Liu, C; Liu, M; Ma, K; Qian, Y; Wang, Y; Wu, Y; Yang, G; Yang, W; Zha, S; Zhang, Y | 1 |
| Hu, XR; Huang, DD; Hung, ZA; Shu, M; Zhang, S | 1 |
| Li, J; Li, WW; Liu, J; Lu, BL; Luo, H; Wen, PY; Yang, FZ; Zhou, J; Zhou, L | 1 |
| Chen, Y; Fan, H; Fu, R; Jiang, C; Wang, H; Wang, Q; Yan, S; Zheng, X; Zhu, X | 1 |
| Cao, H; Cao, Y; Du, Y; Jia, L; Leng, X; Li, X; Lu, R; Ma, Y; Song, N; Wang, J; Xu, Y; Yang, G; Zhang, N; Zhu, M | 1 |
| Braun, JA; Chapman, A; Fernandez Del Ama, L; Hurlstone, AF; Jones, M; Mohr, J; Walker, P | 1 |
| Li, J; Li, WW; Lu, BL; Wu, HF; Zhou, J | 1 |
| Feng, J; Han, D; Yan, J; Yang, X | 1 |
| Dou, LL; Duan, L; Guo, L; Li, P; Liu, EH; Liu, LL; Yang, H | 1 |
| Li, H; Tong, L; Wan, Y; Zhang, L; Zhang, T; Zhao, D | 1 |
| Cai, K; Huang, Y; Huang, Z; Kong, D; Liu, Q; Luo, N; Xu, G | 1 |
| Cheng, D; He, Z; Sun, C; Xu, Y | 1 |
| Chen, HW; Feng, J; Pi, LJ; Wang, J; Zhan, DQ | 1 |
| Choi, YH; Jeon, SJ; Kim, HP; Kim, YS; Son, KH | 1 |
| Li, YS; Wang, J; Wang, ZH | 1 |
| Ha, H; Kim, HH; Kim, HN; Kwak, HB; Lee, JH; Lee, ZH; Shin, HI; Sun, HM | 1 |
| Chen, X; Huang, L; Huang, S; Liu, Y; Shao, F; Wu, H; Yin, Y; Zhang, L; Zhao, Z; Zhuang, J | 1 |
| Lin, YH; Su, CC | 1 |
| Chen, Y; Ma, J; Ren, ZH; Tong, YH; Xu, W | 1 |
| He, Z; Lu, W; Pan, Z | 1 |
| Ahn, SY; Ahn, YM; Chung, JH; Kang, SW; Kim, SD; Kim, SK; Lee, BC; Lee, SH | 1 |
| Chen, Y; Han, H; Hong, D; Qiao, H; Tong, Y; Wu, Y; Xu, W; Yang, J; Zhou, C | 1 |
| Cao, F; Fan, Q; Jin, F; Li, J; Li, Z; Mu, D; Wang, Y; Xie, X; Xu, M; Zhang, B; Zhang, Y; Zhao, P | 1 |
| Chen, M; Huo, Y; Li, J; Lou, L; Pan, C; Singh, G; Wang, S; Wu, A; Zhang, D; Zhao, M | 1 |
| Gao, Y; Liu, Y; Zhou, Y | 1 |
| Fan, G; Gao, X; Hu, L; Jiang, M; Li, X; Wang, X; Wang, Y; Zhu, Y | 1 |
| Chen, J; Liu, SL; Shi, DY; Zhong, L | 1 |
| Liu, CJ; Liu, Z; Shang, T; Xu, C; Zarins, CK; Zhou, M | 1 |
| Han, R; Li, J; Luo, Q; Shen, J; Tang, Q; Xiao, H | 1 |
| Fan, Q; Ma, H; Xin, J; Yu, J; Zhang, C | 2 |
| He, H; Liu, J; Wang, J; Wu, Z; Zhang, S; Zhang, W | 1 |
| Cai, Q; Hua, SY; Li, CS; Tan, JZ; Wang, HW; Zhou, T | 1 |
| Liu, CJ; Liu, Z; Shang, T; Zhou, M | 1 |
| Chen, H; Chen, Y; Liang, Y; Long, B; Zeng, Z | 1 |
| Bao, L; Chen, S; Gao, J; Huang, H; Li, R; Liu, P; Tang, F; Wang, P; Wang, T; Wu, X; Zhang, H | 1 |
| Chan, E; Chen, X; Chowbay, B; Duan, W; Li, CG; Liang, J; Lin, SG; Sheu, FS; Wen, JY; Yu, XQ; Yu, XY; Zhou, SF; Zhou, ZW | 1 |
| Chen, HS; Chen, YC; Liang, YJ; Long, B; Zeng, Z | 1 |
| Fang, ZY; Lin, R; Liu, Y; Yang, GD; Yuan, BX; Zhang, H | 1 |
1 trial(s) available for tanshinone and Disease Models, Animal
| Article | Year |
|---|---|
Tanshinone I and Tanshinone IIA/B attenuate LPS-induced mastitis via regulating the NF-κB.
Topics: Abietanes; Adult; Animals; Anti-Infective Agents; Apoptosis; Breast Feeding; Cefprozil; Cephalosporins; Disease Models, Animal; Drug Therapy, Combination; Female; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Mammary Glands, Animal; Mammary Glands, Human; Mastitis; Mice, Inbred BALB C; NF-kappa B p50 Subunit; Peroxidase; Tumor Necrosis Factor-alpha; Ultrasonography, Mammary | 2021 |
116 other study(ies) available for tanshinone and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Tanshinone IIA derivatives induced S-phase arrest through stabilizing c-myc G-quadruplex DNA to regulate ROS-mediated PI3K/Akt/mTOR pathway.
Topics: Abietanes; Animals; Antineoplastic Agents; Binding Sites; Cell Line; Cell Movement; Cell Proliferation; Disease Models, Animal; DNA Damage; G-Quadruplexes; Humans; Lung Neoplasms; Models, Molecular; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Reactive Oxygen Species; S Phase; Signal Transduction; TOR Serine-Threonine Kinases; Zebrafish | 2021 |
Tanshinone IIA improves degranulation of mast cells and allergic rhinitis induced by ovalbumin by inhibiting the PLCγ1/PKC/IP3R pathway.
Topics: Abietanes; Animals; Cell Degranulation; Cell Line; Disease Models, Animal; Mast Cells; Mice; Ovalbumin; Phospholipase C gamma; Protein Kinase C; Rhinitis, Allergic | 2021 |
Mesenchymal stem cells after the proprocessing of tanshinone IIA attenuate cognitive deficits and oxidative stress injury in an amyloid β-peptide (25-35)-induced rodent model of Alzheimer's disease.
Topics: Abietanes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; Disease Models, Animal; Hippocampus; Male; Mesenchymal Stem Cells; Oxidative Stress; Peptide Fragments; Rats; Rats, Sprague-Dawley; Rodentia | 2022 |
Tanshinone IIA regulates glycogen synthase kinase-3β-related signaling pathway and ameliorates memory impairment in APP/PS1 transgenic mice.
Topics: Abietanes; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Cognition; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Memory Disorders; Mice; Mice, Transgenic; Nootropic Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Salvia miltiorrhiza; Signal Transduction | 2022 |
Tanshinone IIA alleviates ovalbumin-induced allergic rhinitis symptoms by inhibiting Th2 cytokine production and mast cell histamine release in mice.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Cytokines; Dexamethasone; Disease Models, Animal; Histamine Release; Male; Mast Cells; Mice; Mice, Inbred BALB C; Ovalbumin; Rhinitis, Allergic; Th2 Cells | 2022 |
Tanshinone I attenuates fibrosis in fibrotic kidneys through down-regulation of inhibin beta-A.
Topics: Abietanes; Animals; Disease Models, Animal; Down-Regulation; Female; Fibrosis; Humans; Inhibins; Kidney; Kidney Diseases; Male; Mice; Rats; Ureteral Obstruction | 2022 |
Tanshinone IIA improves cardiac function via regulating miR-499-5p dependent angiogenesis in myocardial ischemic mice.
Topics: Abietanes; Animals; Cardiovascular Agents; Disease Models, Animal; Mice; Mice, Inbred C57BL; MicroRNAs; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Neovascularization, Pathologic; Neovascularization, Physiologic; PTEN Phosphohydrolase | 2022 |
Tanshinone IIA ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment in rats through the BDNF/TrkB/GAT1 signaling pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Depression; Disease Models, Animal; Hippocampus; Rats; Signal Transduction; Stress, Psychological | 2023 |
Tanshinone I specifically suppresses NLRP3 inflammasome activation by disrupting the association of NLRP3 and ASC.
Topics: Animals; Anti-Inflammatory Agents; Diabetes Mellitus, Type 2; Disease Models, Animal; Inflammasomes; Interleukin-1beta; Lipopolysaccharides; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Shock, Septic | 2023 |
DNA Methylome and Transcriptome Alterations in High Glucose-Induced Diabetic Nephropathy Cellular Model and Identification of Novel Targets for Treatment by Tanshinone IIA.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Diabetic Nephropathies; Disease Models, Animal; DNA Methylation; Glucose; Inflammation; Mice; Molecular Structure; Oxidative Stress; Transcriptome | 2019 |
Mitigating effect of tanshinone IIA on ventricular remodeling in rats with pressure overload-induced heart failure.
Topics: Abietanes; Animals; Disease Models, Animal; Heart; Heart Failure; Heart Ventricles; Immunosuppressive Agents; Male; Random Allocation; Rats; Ventricular Pressure; Ventricular Remodeling | 2019 |
Effects of the combination of tanshinone IIA and puerarin on cardiac function and inflammatory response in myocardial ischemia mice.
Topics: Abietanes; Animals; CD11 Antigens; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Heart; Heart Function Tests; Heart Ventricles; Hemodynamics; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Isoflavones; Macrophages; Mice; Monocytes; Myocardial Ischemia; Myocardium; RAW 264.7 Cells; Signal Transduction; Ventricular Remodeling | 2019 |
Tanshinone IIA ameliorates the bleomycin-induced endothelial-to-mesenchymal transition via the Akt/mTOR/p70S6K pathway in a murine model of systemic sclerosis.
Topics: Abietanes; Animals; Bleomycin; Cell Line; Disease Models, Animal; Endothelial Cells; Endothelium; Epithelial-Mesenchymal Transition; Female; Fibrosis; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Salvia miltiorrhiza; Scleroderma, Systemic; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Tanshinone IIA protects mice against atherosclerotic injury by activating the TGF-β/PI3K/Akt/eNOS pathway.
Topics: Abietanes; Animals; Aorta, Thoracic; Atherosclerosis; Biomarkers; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Transforming Growth Factor beta | 2020 |
The Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation.
Topics: Abietanes; Animals; Antioxidant Response Elements; Disease Models, Animal; Injections, Intraperitoneal; Male; NADPH Oxidase 4; NF-E2-Related Factor 2; Protective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction; Silicon Dioxide; Silicosis; Smad Proteins; Transforming Growth Factor beta1 | 2019 |
Tanshinone IIA Improves Depression-like Behavior in Mice by Activating the ERK-CREB-BDNF Signaling Pathway.
Topics: Abietanes; Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Mice; Rats; Signal Transduction | 2020 |
Tanshinone IIA Alleviates CCL2-Induced Leaning memory and Cognition Impairment in Rats: A Potential Therapeutic Approach for HIV-Associated Neurocognitive Disorder.
Topics: Abietanes; Animals; Apoptosis; Apoptosis Regulatory Proteins; Chemokine CCL2; Cognition; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; HIV Infections; In Situ Nick-End Labeling; Inflammation; Male; Memory; Memory Disorders; Rats; Rats, Sprague-Dawley | 2020 |
Tanshinone II improves distribution and anti-tumor efficacy of pegylated liposomal doxorubicin via normalizing the structure and function of tumor vasculature in hepa1-6 hepatoma mice model.
Topics: Abietanes; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Disease Models, Animal; Doxorubicin; Drug Therapy, Combination; Female; Humans; Liver Neoplasms; Mice; Mice, Inbred C57BL; Microvessels; Polyethylene Glycols | 2018 |
Tanshinone IIA alleviates hypoxia/reoxygenation induced cardiomyocyte injury via lncRNA AK003290/miR-124-5p signaling.
Topics: Abietanes; Animals; Apoptosis; Cell Hypoxia; Cell Line; Disease Models, Animal; L-Lactate Dehydrogenase; Malate Dehydrogenase; Membrane Potential, Mitochondrial; Mice; MicroRNAs; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Rats; Reactive Oxygen Species; RNA, Long Noncoding; Signal Transduction | 2020 |
Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2/ROS Pathway.
Topics: Abietanes; Animals; Anti-Infective Agents; Disease Models, Animal; Humans; Male; Medicine, Chinese Traditional; Mice; Mice, Knockout; Microscopy, Electron, Transmission; NF-E2-Related Factor 2; Pancreatitis; Reactive Oxygen Species | 2020 |
The regulated profile of noncoding RNAs associated with inflammation by tanshinone IIA on atherosclerosis.
Topics: Abietanes; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cholesterol; Disease Models, Animal; Gene Expression Regulation; Gene Ontology; Genes, Reporter; Inflammation; Male; Mice; Mice, Inbred C57BL; MicroRNAs; RAW 264.7 Cells; Reproducibility of Results; RNA, Circular; RNA, Long Noncoding; Triglycerides | 2020 |
Tanshinone IIA alleviates brain damage in a mouse model of neuromyelitis optica spectrum disorder by inducing neutrophil apoptosis.
Topics: Abietanes; Animals; Apoptosis; Brain; Disease Models, Animal; Mice; Neuromyelitis Optica; Neuroprotective Agents; Neutrophils | 2020 |
Tanshinone IIA alleviates the damage of neurocytes by targeting GLUT1 in ischaemia reperfusion model (in vivo and in vitro experiments).
Topics: Abietanes; Animals; Brain; Brain Ischemia; Disease Models, Animal; Glucose Transporter Type 1; Mice; Mice, Inbred C57BL; Neurons; Recovery of Function; Reperfusion Injury | 2020 |
Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axons; Brain Ischemia; Disease Models, Animal; Humans; Molecular Structure; Myosin Light Chains; Nogo Proteins; Nogo Receptor 1; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; Salvia miltiorrhiza; Signal Transduction | 2020 |
Lipophilic Extract and Tanshinone IIA Derived from
Topics: Abietanes; Animals; Cells, Cultured; Crystallization; Disease Models, Animal; Humans; Hydrophobic and Hydrophilic Interactions; Kidney Calculi; MAP Kinase Signaling System; Mice; Mice, Inbred Strains; Oxidative Stress; Phytotherapy; Plant Extracts; Salvia miltiorrhiza; Uric Acid | 2020 |
Sodium Tanshinone IIA Silate Exerts Microcirculation Protective Effects against Spinal Cord Injury In Vitro and In Vivo.
Topics: Abietanes; Animals; Cell Hypoxia; Cell Survival; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Glucose; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Microcirculation; Protective Agents; Receptors, Notch; Signal Transduction; Spinal Cord; Spinal Cord Injuries | 2020 |
Tanshinone IIA exerts therapeutic effects by acting on endogenous stem cells in rats with liver cirrhosis.
Topics: Abietanes; Animals; Carbon Tetrachloride; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Stem Cells | 2020 |
Efficacy of tanshinone IIA and mesenchymal stem cell treatment of learning and memory impairment in a rat model of vascular dementia.
Topics: Abietanes; Animals; Apoptosis; Dementia, Vascular; Disease Models, Animal; Hippocampus; Humans; Learning; Male; Memory; Mesenchymal Stem Cells; Neurons; Rats; Rats, Sprague-Dawley | 2021 |
A network-based method for mechanistic investigation and neuroprotective effect on treatment of tanshinone Ⅰ against ischemic stroke in mouse.
Topics: Abietanes; Animals; beta Catenin; Brain Ischemia; Cell Line; Cell Survival; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Hippocampus; Ischemic Stroke; Male; MAP Kinase Signaling System; Mice, Inbred ICR; Mitogen-Activated Protein Kinase Kinases; Molecular Docking Simulation; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Interaction Maps; Proto-Oncogene Proteins c-akt; raf Kinases | 2021 |
Tanshinone IIA enhances susceptibility of non-small cell lung cancer cells to NK cell-mediated lysis by up-regulating ULBP1 and DR5.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Biomarkers; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cytotoxicity, Immunologic; Disease Models, Animal; Gene Expression Regulation, Neoplastic; GPI-Linked Proteins; Humans; Intracellular Signaling Peptides and Proteins; Killer Cells, Natural; Lung Neoplasms; Mice; Receptors, TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays | 2021 |
Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation.
Topics: Abietanes; AMP-Activated Protein Kinases; Animals; Autophagy; Disease Models, Animal; Female; Furans; Gout; Humans; Inflammasomes; Inflammation; Male; Mice; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Phenanthrenes; Quinones; Rats; Reactive Oxygen Species; Shock, Septic; Uric Acid | 2021 |
Nose-to-brain delivery of borneol modified tanshinone IIA nanoparticles in prevention of cerebral ischemia/reperfusion injury.
Topics: Abietanes; Adjuvants, Pharmaceutic; Administration, Intranasal; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Brain Ischemia; Camphanes; Chemistry, Pharmaceutical; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Malondialdehyde; Nanoparticles; Neuroprotective Agents; Particle Size; Polyethylene Glycols; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Reperfusion Injury; Succinimides; Superoxide Dismutase | 2021 |
Tanshinone IIA ameliorates lead (Pb)-induced cognitive deficits and oxidative stress in a rat pup model.
Topics: Abietanes; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; Lead Poisoning, Nervous System; Lipid Peroxidation; Male; Memory; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2017 |
Articular cartilage degradation is prevented by tanshinone IIA through inhibiting apoptosis and the expression of inflammatory cytokines.
Topics: Abietanes; Animals; Anterior Cruciate Ligament; Apoptosis; Bone Morphogenetic Proteins; Cartilage, Articular; Chondrocytes; Cytokines; Disease Models, Animal; Inflammation; Interleukin-1beta; Male; Menisci, Tibial; Nitric Oxide; Osteoarthritis; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2017 |
Antifatigue properties of tanshinone IIA in mice subjected to the forced swimming test.
Topics: Abietanes; Animals; Blood Glucose; Blood Urea Nitrogen; Disease Models, Animal; Dose-Response Relationship, Drug; Fatigue; Female; Lactic Acid; Malondialdehyde; Mice; Salvia miltiorrhiza; Superoxide Dismutase; Swimming | 2017 |
Tanshinone IIA prevents left ventricular remodelling via the TLR4/MyD88/NF-κB signalling pathway in rats with myocardial infarction.
Topics: Abietanes; Animals; Apoptosis; Disease Models, Animal; Gene Expression Regulation; Humans; Macrophages; Myeloid Differentiation Factor 88; Myocardial Infarction; Myocytes, Cardiac; NF-kappa B; Rats; Signal Transduction; Toll-Like Receptor 4; Transcription Factor RelA; Ventricular Remodeling | 2018 |
Tanshinone IIA exerts neuroprotective effects on hippocampus-dependent cognitive impairments in diabetic rats by attenuating ER stress-induced apoptosis.
Topics: Abietanes; Animals; Apoptosis; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Hippocampus; Male; Malondialdehyde; Maze Learning; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Streptozocin; Superoxide Dismutase; Transcription Factor CHOP | 2018 |
Simultaneous purification of dihydrotanshinone, tanshinone I, cryptotanshinone, and tanshinone IIA from Salvia miltiorrhiza and their anti-inflammatory activities investigation.
Topics: Abietanes; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Cytokines; Disease Models, Animal; Kidney; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Nitric Oxide; Phenanthrenes; RAW 264.7 Cells; Salvia miltiorrhiza; Sepsis | 2018 |
Tanshinone IIA promotes the differentiation of bone marrow mesenchymal stem cells into neuronal-like cells in a spinal cord injury model.
Topics: Abietanes; Animals; Biomarkers; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Female; Gene Expression Regulation; Image Processing, Computer-Assisted; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Motor Activity; Myelin Sheath; Neuroglia; Neurons; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries | 2018 |
Tanshinone IIA activates autophagy to reduce liver ischemia-reperfusion injury by MEK/ERK/mTOR pathway.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Autophagy; Cytokines; Disease Models, Animal; Hepatocytes; Liver; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Reperfusion Injury; TOR Serine-Threonine Kinases | 2018 |
Tanshinone IIA attenuates paraquat‑induced acute lung injury by modulating angiotensin‑converting enzyme 2/angiotensin‑(1‑7) in rats.
Topics: Abietanes; Acute Lung Injury; Angiotensin I; Angiotensin-Converting Enzyme 2; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Biopsy; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Gene Expression; Immunohistochemistry; L-Lactate Dehydrogenase; Male; Neutrophil Infiltration; Paraquat; Peptide Fragments; Peptidyl-Dipeptidase A; Rats | 2018 |
Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctions in a mice model: role of NF-κB pathway.
Topics: Abietanes; Animals; Disease Models, Animal; Drug Delivery Systems; Humans; Mice; Myocardial Infarction; Nanoparticles; NF-kappa B; Signal Transduction; Ventricular Remodeling | 2018 |
RETRACTED: Tanshinone IIA alleviates oxidative damage after spinal cord injury in vitro and in vivo through up-regulating miR-124.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Autophagy; Cell Proliferation; Cell Survival; Disease Models, Animal; Down-Regulation; Flow Cytometry; Hydrogen Peroxide; MAP Kinase Signaling System; MicroRNAs; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Up-Regulation | 2019 |
Anti-allergic effects of salvianolic acid A and tanshinone IIA from Salvia miltiorrhiza determined using in vivo and in vitro experiments.
Topics: Abietanes; Animals; Anti-Allergic Agents; beta-N-Acetylhexosaminidases; Caffeic Acids; Cell Degranulation; Cell Line; Cytokines; Disease Models, Animal; Female; Humans; Hypersensitivity; Lactates; Mast Cells; Mice; Mice, Inbred BALB C; Mucins; Rats; Salvia miltiorrhiza; Th2 Cells | 2019 |
Tanshinone IIA Ameliorate Coxsackie Virus B3-Induced Viral Myocarditis through the Inhibition of Inflammation and Modulation T Helper 1/T Helper 2 Balance in Mice.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Coxsackievirus Infections; Cytokines; Disease Models, Animal; Enterovirus; Inflammation Mediators; Male; Mice, Inbred BALB C; Myocarditis; Myocardium; Th1 Cells; Th1-Th2 Balance; Th2 Cells | 2019 |
Tanshinone IIA attenuates sepsis-induced immunosuppression and improves survival rate in a mice peritonitis model.
Topics: Abietanes; Animals; Anti-Infective Agents; Disease Models, Animal; Immunosuppression Therapy; Immunosuppressive Agents; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Peritonitis; Sepsis; Survival Rate | 2019 |
Neuroprotective effect of tanshinone IIA-incubated mesenchymal stem cells on Aβ
Topics: Abietanes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Hippocampus; Learning; Male; Memory; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Neuroimmunomodulation; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2019 |
Tanshinone IIA harmonizes the crosstalk of autophagy and polarization in macrophages via miR-375/KLF4 pathway to attenuate atherosclerosis.
Topics: Abietanes; Animals; Apolipoproteins E; Atherosclerosis; Autophagy; Cell Differentiation; Cells, Cultured; Diet, High-Fat; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Receptor Cross-Talk; Salvia miltiorrhiza; Signal Transduction | 2019 |
Tanshinone IIA Ameliorates Spatial Learning and Memory Deficits by Inhibiting the Activity of ERK and GSK-3β.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Humans; Male; MAP Kinase Signaling System; Memory Disorders; Rats; Rats, Sprague-Dawley; Spatial Learning | 2019 |
Rapid Identification of Tanshinone IIA Metabolites in an Amyloid-β
Topics: Abietanes; Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Chromatography, High Pressure Liquid; Disease Models, Animal; Male; Mass Spectrometry; Metabolomics; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2019 |
[Study on regulation of tanshinone II(A) on GFAP and ATPase and PDI of cerebral ischemia reperfusion injury in rats].
Topics: Abietanes; Adenosine Triphosphatases; Animals; Brain; Brain Ischemia; Disease Models, Animal; Glial Fibrillary Acidic Protein; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Protein Disulfide-Isomerases; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Rhizome; Salvia miltiorrhiza | 2012 |
Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.
Topics: Abietanes; Alzheimer Disease; Animals; Anticonvulsants; Brain Ischemia; Disease Models, Animal; Disease Progression; Drugs, Chinese Herbal; Fertilization in Vitro; Injections, Intraventricular; Larva; Male; Medicine, Chinese Traditional; Mice; Microinjections; Neuroprotective Agents; Pentylenetetrazole; Plant Extracts; Plant Roots; Proto-Oncogene Proteins c-fos; Salvia miltiorrhiza; Seizures; Small Molecule Libraries; Zebrafish | 2013 |
Tanshinone IIA inhibits human prostate cancer cells growth by induction of endoplasmic reticulum stress in vitro and in vivo.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drugs, Chinese Herbal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; G1 Phase Cell Cycle Checkpoints; Humans; Male; Mitochondria; Prostatic Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
Tanshinone IIA attenuates elastase-induced AAA in rats via inhibition of MyD88-dependent TLR-4 signaling.
Topics: Abietanes; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; I-kappa B Proteins; Male; Myeloid Differentiation Factor 88; NF-kappa B; NF-KappaB Inhibitor alpha; Pancreatic Elastase; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4; Up-Regulation | 2014 |
[Effects of tanshinone IIA on the expressions of caspase-3, Akt and NF-κB in the brains of rat models of Alzheimer's disease].
Topics: Abietanes; Alzheimer Disease; Animals; Apoptosis; Brain; Caspase 3; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Male; Neuroprotective Agents; NF-kappa B; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley | 2014 |
A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.
Topics: Abietanes; Animals; Animals, Genetically Modified; Anti-Inflammatory Agents; Apoptosis; Cell Movement; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Inflammation; Larva; Neutrophil Infiltration; Neutrophils; Signal Transduction; Time Factors; Translational Research, Biomedical; Zebrafish | 2014 |
Effectiveness of combination therapy of atorvastatin and non lipid-modifying tanshinone IIA from Danshen in a mouse model of atherosclerosis.
Topics: Abietanes; Animals; Atherosclerosis; Atorvastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drugs, Chinese Herbal; Heptanoic Acids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrroles; Salvia miltiorrhiza; Treatment Outcome | 2014 |
Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP‑2 and NF‑κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease.
Topics: Abietanes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Male; Matrix Metalloproteinase 2; Maze Learning; Memory; Neuroprotective Agents; Nitric Oxide Synthase Type II; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Temporal Lobe; Transcription Factor RelA | 2014 |
[Study on pharmacokinetics-pharmacodynamics correlation of yin teng gu bi kang prescription].
Topics: Abietanes; Administration, Oral; Animals; Antioxidants; Area Under Curve; Blood Coagulation; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; Male; Malondialdehyde; Plants, Medicinal; Random Allocation; Rats; Rats, Sprague-Dawley | 2014 |
Tanshinone IIA attenuates hypoxic pulmonary hypertension via modulating KV currents.
Topics: Abietanes; Animals; Blotting, Western; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Pulmonary Artery; Rats; Reverse Transcriptase Polymerase Chain Reaction | 2015 |
Tanshinone IIA attenuates neuropathic pain via inhibiting glial activation and immune response.
Topics: Abietanes; Analgesics; Animals; Disease Models, Animal; Drugs, Chinese Herbal; Hyperalgesia; Interleukin-1beta; Male; MAP Kinase Signaling System; Neuralgia; Neuroglia; Oxidative Stress; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Spinal Cord; Tumor Necrosis Factor-alpha | 2015 |
Tanshinone IIA prevents the loss of nigrostriatal dopaminergic neurons by inhibiting NADPH oxidase and iNOS in the MPTP model of Parkinson's disease.
Topics: Abietanes; Animals; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; Male; Mice; Mice, Inbred C57BL; Microglia; MPTP Poisoning; NADPH Oxidases; Neostriatum; Neuroprotective Agents; Nitric Oxide Synthase Type II; Substantia Nigra | 2015 |
Janus kinase/signal transducer and activator of transcription inhibitors enhance the protective effect mediated by tanshinone IIA from hypoxic/ischemic injury in cardiac myocytes.
Topics: Abietanes; Animals; Apoptosis; Cardiotonic Agents; Cell Survival; Disease Models, Animal; Janus Kinase 2; Janus Kinases; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protein Kinase Inhibitors; Rats; Signal Transduction; STAT Transcription Factors | 2015 |
Tanshinone IIA attenuates the cerebral ischemic injury-induced increase in levels of GFAP and of caspases-3 and -8.
Topics: Abietanes; Animals; Blotting, Western; Brain Ischemia; Caspase 3; Caspase 8; Cell Death; Disease Models, Animal; Entorhinal Cortex; Glial Fibrillary Acidic Protein; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Random Allocation; Rats, Sprague-Dawley | 2015 |
microRNA-29b Mediates the Antifibrotic Effect of Tanshinone IIA in Postinfarct Cardiac Remodeling.
Topics: Abietanes; Animals; Cells, Cultured; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Fibroblasts; Fibrosis; Male; MicroRNAs; Myocardial Infarction; Myocardium; Rats, Sprague-Dawley; Recovery of Function; RNA Interference; Smad3 Protein; Transfection; Transforming Growth Factor beta1; Up-Regulation; Ventricular Function, Left; Ventricular Remodeling | 2015 |
Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Abietanes; Animals; Anti-Inflammatory Agents; Ants; Cell Line; Corpus Striatum; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Gene Expression Regulation; Male; Membrane Proteins; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; NF-kappa B; Nitric Oxide; Parkinsonian Disorders; Phytotherapy; Rotarod Performance Test | 2015 |
Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats.
Topics: Abietanes; Animals; Antibiotics, Antineoplastic; Bleomycin; Bronchoalveolar Lavage Fluid; Cell Count; Cyclooxygenase 2; Disease Models, Animal; Drugs, Chinese Herbal; Inflammation; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Pulmonary Fibrosis; Rats | 2015 |
Tanshinone IIA attenuates renal fibrosis and inflammation via altering expression of TGF-β/Smad and NF-κB signaling pathway in 5/6 nephrectomized rats.
Topics: Abietanes; Animals; Blotting, Western; Disease Models, Animal; Drugs, Chinese Herbal; Fibrosis; Gene Expression; Immunohistochemistry; Kidney; Kidney Function Tests; Male; Medicine, Chinese Traditional; Nephrectomy; NF-kappa B; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Renal Insufficiency, Chronic; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2015 |
Anti-inflammatory effects of tanshinone IIA on atherosclerostic vessels of ovariectomized ApoE mice are mediated by estrogen receptor activation and through the ERK signaling pathway.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apolipoproteins E; Atherosclerosis; Diet, High-Fat; Disease Models, Animal; Estradiol; Estrogens; Extracellular Signal-Regulated MAP Kinases; Female; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Ovariectomy; Oxidative Stress; Receptors, Estrogen; Signal Transduction; Superoxide Dismutase; Triglycerides | 2015 |
Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors.
Topics: Abietanes; Animals; Disease Models, Animal; Hyperalgesia; Injections, Spinal; Interleukins; Male; Mice; Mice, Inbred C3H; Myelitis; Osteosarcoma; Pain; Tumor Necrosis Factor-alpha | 2015 |
Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain.
Topics: Abietanes; Analgesics; Analysis of Variance; Animals; Chemokine CCL2; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; MAP Kinase Signaling System; Movement Disorders; Neuralgia; Pain Threshold; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerves | 2015 |
[Tanshinone attenuates myocardial injury via activating JAK2/STAT1 pathway in a murine model of viral myocarditis].
Topics: Abietanes; Animals; Blotting, Western; Coxsackievirus Infections; Disease Models, Animal; Heart Injuries; Janus Kinase 2; Male; Mice; Mice, Inbred BALB C; Myocarditis; Myocardium; Signal Transduction; STAT1 Transcription Factor; Troponin I | 2015 |
Tanshinone IIA - loaded pellets developed for angina chronotherapy: Deconvolution-based formulation design and optimization, pharmacokinetic and pharmacodynamic evaluation.
Topics: Abietanes; Administration, Oral; Angina Pectoris; Animals; Cardiovascular Agents; Chemistry, Pharmaceutical; Computer Simulation; Delayed-Action Preparations; Disease Models, Animal; Drug Chronotherapy; Excipients; Male; Models, Biological; Nitric Oxide; Polyethylene Glycols; Polyvinyl Alcohol; Polyvinyls; Rabbits; Solubility; Technology, Pharmaceutical | 2015 |
Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response element signaling pathway.
Topics: Abietanes; Animals; Apomorphine; Apoptosis; Cell Survival; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Gene Expression Regulation; Glutathione; Humans; Male; Mice; Mice, Inbred C57BL; Neuroblastoma; Neuroprotective Agents; Neurotoxicity Syndromes; NF-E2-Related Factor 2; Oxidopamine; Reactive Oxygen Species; Signal Transduction; Stereotyped Behavior; Time Factors; Tyrosine 3-Monooxygenase | 2015 |
Upregulation effects of Tanshinone IIA on the expressions of NeuN, Nissl body, and IκB and downregulation effects on the expressions of GFAP and NF-κB in the brain tissues of rat models of Alzheimer's disease.
Topics: Abietanes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Nuclear; Brain; Disease Models, Animal; Down-Regulation; Glial Fibrillary Acidic Protein; I-kappa B Proteins; Male; Nerve Tissue Proteins; Neuroprotective Agents; NF-kappa B; Nissl Bodies; Peptide Fragments; Rats; Rats, Sprague-Dawley; Up-Regulation | 2015 |
Effects of albendazole combined with TSII-A (a Chinese herb compound) on optic neuritis caused by Angiostrongylus cantonensis in BALB/c mice.
Topics: Abietanes; Albendazole; Angiostrongylus cantonensis; Animals; Anti-Infective Agents; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Drugs, Chinese Herbal; Mice; Mice, Inbred BALB C; Optic Neuritis; Strongylida Infections | 2015 |
Treatment effects of tanshinone IIA against intracerebroventricular streptozotocin induced memory deficits in mice.
Topics: Abietanes; Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; Infusions, Intraventricular; Male; Malondialdehyde; Maze Learning; Memory Disorders; Mice; Neurons; Neuroprotective Agents; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Parietal Lobe; Random Allocation; Streptozocin; Superoxide Dismutase | 2016 |
Effects of tanshinone IIA on fibrosis in a rat model of cirrhosis through heme oxygenase-1, inflammation, oxidative stress and apoptosis.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Biomarkers; Cytokines; Disease Models, Animal; Fibrosis; Heme Oxygenase-1; Inflammation; Inflammation Mediators; Male; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Rats | 2016 |
Tanshinone IIA increases levels of NeuN, protein disulfide isomerase, and Na+/K+-ATPase and decreases evidence of microglial activation after cerebral ischemic injury.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; CD11b Antigen; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Nervous System Diseases; Phosphopyruvate Hydratase; Protein Disulfide-Isomerases; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 2016 |
Insight into the pharmacokinetic behavior of tanshinone IIA in the treatment of Crohn's disease: comparative data for tanshinone IIA and its two glucuronidated metabolites in normal and recurrent colitis models after oral administration.
Topics: Abietanes; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Crohn Disease; Disease Models, Animal; Glucuronosyltransferase; Mice; Trinitrobenzenesulfonic Acid; UDP-Glucuronosyltransferase 1A9 | 2017 |
Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats.
Topics: Abietanes; Animals; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; Disease Models, Animal; Gene Expression Regulation; Hyperlipidemias; Lipid Metabolism; Lipids; Liver; Male; MicroRNAs; Proprotein Convertase 9; Rats; Receptors, LDL; Signal Transduction; Sterol Regulatory Element Binding Protein 2 | 2016 |
Reprofiling using a zebrafish melanoma model reveals drugs cooperating with targeted therapeutics.
Topics: Abietanes; Animals; Animals, Genetically Modified; Apoptosis; Benzamides; Cell Line, Tumor; Disease Models, Animal; Disulfiram; Drug Repositioning; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase Kinases; Melanins; Melanocytes; Melanoma; Oligonucleotides, Antisense; Phenotype; Protein Kinase Inhibitors; Signal Transduction; Sirolimus; Skin Neoplasms; Zebrafish | 2016 |
Tanshinone IIA decreases the levels of inflammation induced by Aβ1-42 in brain tissues of Alzheimer's disease model rats.
Topics: Abietanes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Astrocytes; Brain; CD11b Antigen; Complement C1q; Complement C3c; Complement C3d; Disease Models, Animal; Encephalitis; Interleukin-1beta; Interleukin-6; Male; Peptide Fragments; Rats, Sprague-Dawley | 2016 |
Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats.
Topics: Abietanes; Animals; Biomarkers; Brain; CD4 Antigens; CD8 Antigens; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression; Guinea Pigs; Immunohistochemistry; Immunosuppressive Agents; Interleukin-17; Interleukin-23; Macrophage-1 Antigen; Multiple Sclerosis; Rats | 2016 |
Quality standardization of herbal medicines using effective compounds combination as labeled constituents.
Topics: Abietanes; Animals; Disease Models, Animal; Drugs, Chinese Herbal; Herbal Medicine; Male; Myocardial Ischemia; Myocytes, Cardiac; Plants, Medicinal; Quality Control; Rats; Rats, Sprague-Dawley; Reference Standards | 2016 |
Tanshinone II A stabilizes vulnerable plaques by suppressing RAGE signaling and NF-κB activation in apolipoprotein-E-deficient mice.
Topics: Abietanes; Animals; Aorta, Thoracic; Apolipoproteins E; Atherosclerosis; Biopsy; Disease Models, Animal; Immunohistochemistry; Inflammation Mediators; Male; MAP Kinase Signaling System; Matrix Metalloproteinases; Mice; Mice, Knockout; NF-kappa B; Plaque, Atherosclerotic; Receptor for Advanced Glycation End Products; Signal Transduction | 2016 |
Synergistic effect of tanshinone IIA and mesenchymal stem cells on preventing learning and memory deficits via anti-apoptosis, attenuating tau phosphorylation and enhancing the activity of central cholinergic system in vascular dementia.
Topics: Abietanes; Acetylcholine; Animals; Apoptosis; Dementia, Vascular; Disease Models, Animal; Hippocampus; Male; Memory; Memory Disorders; Mesenchymal Stem Cells; Phosphorylation; Rats, Sprague-Dawley; tau Proteins | 2017 |
Reduction of atrial fibrillation by Tanshinone IIA in chronic heart failure.
Topics: Abietanes; Acetylcholine; Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Cardiac Pacing, Artificial; Chronic Disease; Disease Models, Animal; Echocardiography; Electrocardiography; Female; Heart Atria; Heart Failure; Heart Rate; Isolated Heart Preparation; Isoproterenol; Rabbits; Refractory Period, Electrophysiological; Time Factors | 2016 |
Protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats through inhibiting the Cys-C/Wnt signaling pathway.
Topics: Abietanes; Animals; Arginine; Cardiomegaly; Cardiovascular Agents; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type III; Cystatin C; Disease Models, Animal; Hypertension; Male; Myocardium; NADPH Oxidase 4; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Troponin I; Wnt Signaling Pathway | 2017 |
Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Edema; Electrophoretic Mobility Shift Assay; Furans; Lipopolysaccharides; Macrophages; Male; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phenanthrenes; Plant Roots; Quinones; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2008 |
[Effect of tanshinone II A on angiotensin receptor in hypertrophic myocardium of rats with pressure over-loading].
Topics: Abietanes; Animals; Blood Pressure; Calcium; Cardiomyopathy, Hypertrophic; Disease Models, Animal; Female; Humans; Male; Myocardium; Phenanthrenes; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin | 2008 |
Tanshinone IIA suppresses inflammatory bone loss by inhibiting the synthesis of prostaglandin E2 in osteoblasts.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Diseases; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Regulation; Inflammation; Male; Mice; Mice, Inbred ICR; Osteoblasts; Osteoclasts; Phenanthrenes | 2008 |
Effect of tanshinone on the levels of nitric oxide synthase and acetylcholinesterase in the brain of Alzheimer's disease rat model.
Topics: Abietanes; Acetylcholinesterase; Alzheimer Disease; Animals; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hippocampus; Immunosuppressive Agents; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Phenanthrenes; Rats; Rats, Sprague-Dawley | 2008 |
Tanshinone IIA down-regulates the protein expression of ErbB-2 and up-regulates TNF-alpha in colon cancer cells in vitro and in vivo.
Topics: Abietanes; Actins; Animals; Antineoplastic Agents, Phytogenic; Caspase 3; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Down-Regulation; Humans; Male; Mice; Mice, SCID; Neoplasm Transplantation; Phenanthrenes; Receptor, ErbB-2; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
Tanshinone II A attenuates inflammatory responses of rats with myocardial infarction by reducing MCP-1 expression.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Chemokine CCL2; Coronary Vessels; Disease Models, Animal; Drugs, Chinese Herbal; Fibroblasts; Heart; Inflammation; Macrophages; Male; Myocardial Infarction; Myocardium; Myocytes, Cardiac; NF-kappa B; Phenanthrenes; Phytotherapy; Plant Roots; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2010 |
[Neuroprotective effects of tanshinone II A on vascular dementia in rats].
Topics: Abietanes; Animals; Dementia, Vascular; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Male; Malondialdehyde; Maze Learning; Memory; Neuroprotective Agents; Phenanthrenes; Random Allocation; Rats; Rats, Sprague-Dawley | 2010 |
Renoprotective effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, on rats with chronic kidney disease.
Topics: Abietanes; Administration, Oral; Angiotensin II; Animals; Collagen Type IV; Creatinine; Disease Models, Animal; Drugs, Chinese Herbal; Kidney; Male; Phenanthrenes; Proteinuria; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Salvia miltiorrhiza; Transforming Growth Factor beta1 | 2010 |
Tanshinone IIA increases recruitment of bone marrow mesenchymal stem cells to infarct region via up-regulating stromal cell-derived factor-1/CXC chemokine receptor 4 axis in a myocardial ischemia model.
Topics: Abietanes; Animals; Benzylamines; Bone Marrow Cells; Cell Movement; Chemokine CXCL12; Cyclams; Disease Models, Animal; Drugs, Chinese Herbal; Female; Heterocyclic Compounds; Male; Mesenchymal Stem Cells; Myocardial Infarction; Myocardial Ischemia; Myocardium; Phytotherapy; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Salvia miltiorrhiza; Stem Cell Transplantation; Up-Regulation | 2011 |
Tanshinone IIA ameliorates seawater exposure-induced lung injury by inhibiting aquaporins (AQP) 1 and AQP5 expression in lung.
Topics: Abietanes; Animals; Aquaporin 1; Aquaporin 5; Blotting, Western; Cell Line; Disease Models, Animal; Drowning; Humans; Immunohistochemistry; Lung; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Reverse Transcriptase Polymerase Chain Reaction; Seawater | 2011 |
Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways.
Topics: Abietanes; Amino Acid Transport Systems, Basic; AMP-Activated Protein Kinases; Analysis of Variance; Animals; Arginine; Benzofurans; Cardiovascular Agents; Cationic Amino Acid Transporter 1; Cells, Cultured; Chromones; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelial Cells; Enzyme Inhibitors; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Myocardial Infarction; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; Time Factors; Vasodilation | 2011 |
[Effect of tanshitone on prevention and treatment of retinoic acid induced osteoporosis in mice].
Topics: Abietanes; Alkaline Phosphatase; Animals; Bone Density; Disease Models, Animal; Drugs, Chinese Herbal; Female; Humans; Male; Mice; Osteoporosis; Phenanthrenes; Tretinoin | 2010 |
Differential cardioprotective effects of salvianolic acid and tanshinone on acute myocardial infarction are mediated by unique signaling pathways.
Topics: Abietanes; Animals; Apoptosis; Caffeic Acids; Calcium; Cardiovascular Agents; Cell Adhesion; Complement Pathway, Alternative; Disease Models, Animal; Drugs, Chinese Herbal; Estrogens; Gene Expression Regulation; Heart; Lactates; Male; Microarray Analysis; Myocardial Infarction; Oxidative Stress; Phenanthrolines; Phytotherapy; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Salvia miltiorrhiza; Selective Estrogen Receptor Modulators; Signal Transduction; Systole | 2011 |
Tanshinone IIA induces growth inhibition and apoptosis in gastric cancer in vitro and in vivo.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Humans; Male; Mice; Mice, Nude; Signal Transduction; Stomach Neoplasms; Xenograft Model Antitumor Assays | 2012 |
Inhibition of experimental abdominal aortic aneurysm in a rat model by way of tanshinone IIA.
Topics: Abietanes; Animals; Aortic Aneurysm, Abdominal; Blood Pressure; Disease Models, Animal; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2012 |
Neuroprotective effects of tanshinone IIA and/or tetramethylpyrazine in cerebral ischemic injury in vivo and in vitro.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Brain Ischemia; Calcium; Cerebral Cortex; Disease Models, Animal; Drug Therapy, Combination; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2012 |
Anticancer activities of tanshinone microemulsion against hepatocellular carcinoma in vitro and in vivo.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Models, Animal; Emulsions; Female; Gene Expression Regulation, Neoplastic; Liver Neoplasms; Male; Mice; Proto-Oncogene Proteins c-bcl-2; Tumor Burden | 2013 |
Pharmacokinetics and atherosclerotic lesions targeting effects of tanshinone IIA discoidal and spherical biomimetic high density lipoproteins.
Topics: Abietanes; Animals; Aorta, Thoracic; Atherosclerosis; Azo Compounds; Biomimetic Materials; Carotid Intima-Media Thickness; Cholesterol; Collagen; Disease Models, Animal; Lipoproteins; Lipoproteins, HDL; Macrophages; Phosphatidylcholine-Sterol O-Acyltransferase; Rabbits; Recombinant Proteins; Static Electricity; Transcription Factor RelA | 2013 |
Neutroprotective efficacy of sodium tanshinone B on hippocampus neuron in a rat model of focal cerebral ischemia.
Topics: Abietanes; Animals; Brain Ischemia; Cytoprotection; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Hippocampus; Models, Biological; Neurons; Neuroprotective Agents; Random Allocation; Rats; Reperfusion Injury; Treatment Outcome | 2012 |
[Tanshinone IIA attenuates the development of elastase-induced abdominal aortic aneurysm of rat].
Topics: Abietanes; Animals; Aortic Aneurysm, Abdominal; Chemokine CCL2; Disease Models, Animal; Elastic Tissue; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Nitric Oxide Synthase Type II; Pancreatic Elastase; Rats; Rats, Sprague-Dawley | 2012 |
Novel microemulsion of tanshinone IIA, isolated from Salvia miltiorrhiza Bunge, exerts anticancer activity through inducing apoptosis in hepatoma cells.
Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Disease Models, Animal; Emulsions; Female; Gene Expression Regulation, Neoplastic; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Salvia miltiorrhiza; Tumor Cells, Cultured | 2013 |
[Inhibitive effect to collagen fiber of tanshinone II A in iliac artery following balloon injury in rabbit].
Topics: Abietanes; Animals; Catheterization; Collagen; Coronary Restenosis; Disease Models, Animal; Iliac Artery; Male; Muscle, Smooth, Vascular; Phenanthrenes; Plants, Medicinal; Rabbits; Salvia; Tunica Intima; Tunica Media | 2005 |
Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress.
Topics: Abietanes; Animals; Antioxidants; Aorta, Thoracic; Atherosclerosis; Calcinosis; Calcium; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Ergocalciferols; Lipoproteins, LDL; Male; Malondialdehyde; Oxidative Stress; Phenanthrenes; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxide Dismutase; Superoxides; Time Factors | 2007 |
Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Brain; Brain Infarction; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Infarction, Middle Cerebral Artery; Injections, Intraperitoneal; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Phenanthrenes; Plant Extracts; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Stroke; Treatment Outcome | 2007 |
[The inhibitive effect of sodium tanshinone II A sulfonic acid on intimal hyperplasia in rabbit iliac artery ballon injury model].
Topics: Abietanes; Animals; Apoptosis; Catheterization; Disease Models, Animal; Drugs, Chinese Herbal; Hyperplasia; Iliac Artery; Injections, Intravenous; Male; Phenanthrenes; Plants, Medicinal; Rabbits; Sulfonic Acids; Tunica Intima; Tunica Media | 2007 |
Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit.
Topics: Abietanes; Animals; Anti-Inflammatory Agents; Antioxidants; Atherosclerosis; CD40 Antigens; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Female; Male; Malondialdehyde; Matrix Metalloproteinase 2; Phenanthrenes; Plant Roots; Rabbits; Salvia miltiorrhiza; Superoxide Dismutase | 2008 |