tanshinone has been researched along with Brain Ischemia in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (7.41) | 29.6817 |
| 2010's | 18 (66.67) | 24.3611 |
| 2020's | 7 (25.93) | 2.80 |
| Authors | Studies |
|---|---|
| Du, S; Liu, L; Miao, Q; Sun, X; Wang, R | 1 |
| Tong, H; Wang, J; Wang, X; Wang, Y | 1 |
| Han, Y; Jia, L; Liu, Y; Ni, G; Wang, J; Wang, Y | 1 |
| Jiang, Y; Liu, J; Sheng, P; Wang, F; Xia, Z; Yan, BC | 1 |
| Cai, X; Huang, Y; Peng, X; Song, Q; Wang, B; Wang, C; Xiong, X; Ye, X; Zeng, T; Zhang, C | 1 |
| Gaire, BP; Subedi, L | 1 |
| Du, J; Feng, J; Hu, K; Liu, M; Wang, L; Xu, L; Zhao, X | 1 |
| Fang, C; Fu, C; Liu, C; Liu, H; Xie, L; Ye, W; Zhang, B | 1 |
| Huang, LH; Li, WW; Wang, F; Wen, PY; Yang, FZ; Zhou, J; Zhou, L | 1 |
| An, C; Ji, L; Liu, X; Pan, L; Ye, M | 1 |
| Buenafe, OE; Crawford, AD; De Borggraeve, W; de Witte, P; Esguerra, CV; Huang, H; Luyten, W; Maes, J; Orellana-Paucar, A; Ying, X | 1 |
| Ahn, JH; Chen, BH; Cho, JH; Choi, JH; Hwang, IK; Kim, IH; Kwon, SH; Lee, CH; Lee, JC; Lee, YL; Park, JH; Park, Ok; Won, MH; Yan, BC; Yoo, KY | 1 |
| Ahn, JH; Choi, JH; Hwang, IK; Kim, IH; Kim, JD; Kwon, SH; Lee, CH; Lee, JC; Park, JH; Park, OK; Won, MH; Yan, B; Yoo, KY | 1 |
| Bondy, SC; Jian, L; Li, W; Luo, H; Wen, P; Yang, F; Zhou, J; Zhou, L | 1 |
| Cai, M; Dong, H; Guo, Y; Sun, S; Wang, S; Wei, H; Zhao, G | 1 |
| Dong, K; Qiao, H; Wu, L; Xu, W; Yang, J | 1 |
| Cui, L; Du, W; Li, M; Liu, L; Wang, L; Yang, R; Zhang, X | 1 |
| Cui, L; Du, W; Li, M; Liu, L; Wang, L; Wang, S; Yang, R; Zhang, X | 1 |
| Chen, WY; Huang, M; Liu, FY; Sun, CM; Wang, HM; Zhu, BD; Zhu, GX | 1 |
| Bi, Z; Cai, B; Lu, Y; Shan, H; Yang, L; Yin, L; Zhang, B; Zhang, L | 1 |
| Bi, XY; Chen, L; Deng, BQ; Ding, SJ; Qiu, YQ; Zhu, LX | 1 |
| Chen, Y; Li, L; Lin, X; Wu, J; Wu, X; Yu, S; Zhao, J; Zhao, Y | 1 |
| Han, R; Li, J; Luo, Q; Shen, J; Tang, Q; Xiao, H | 1 |
| Cai, Q; Hua, SY; Li, CS; Tan, JZ; Wang, HW; Zhou, T | 1 |
| An, C; Jin, P; Liu, X; Wang, L | 1 |
| Cai, Q; Huang, SY; Tan, JZ | 1 |
| Chung, SK; Lam, BY; Lo, AC; Luo, HW; Sucher, NJ; Sun, X | 1 |
1 review(s) available for tanshinone and Brain Ischemia
| Article | Year |
|---|---|
Tanshinone IIA: A phytochemical as a promising drug candidate for neurodegenerative diseases.
Topics: Abietanes; Alzheimer Disease; Animals; Brain Ischemia; Humans; Multiple Sclerosis; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease | 2021 |
1 trial(s) available for tanshinone and Brain Ischemia
| Article | Year |
|---|---|
[Flavonoids of puerarin versus tanshinone II A for ischemic stroke: a randomized controlled trial].
Topics: Abietanes; Aged; Aged, 80 and over; Brain Ischemia; Brain-Derived Neurotrophic Factor; Female; Humans; Interleukin-6; Isoflavones; L-Lactate Dehydrogenase; Male; Middle Aged; Phytotherapy; Stroke; Treatment Outcome; Vasodilator Agents | 2011 |
25 other study(ies) available for tanshinone and Brain Ischemia
| Article | Year |
|---|---|
Combination of puerarin and tanshinone IIA alleviates ischaemic stroke injury in rats
Topics: Abietanes; Animals; Brain Injuries; Brain Ischemia; Infarction, Middle Cerebral Artery; Ischemic Stroke; Isoflavones; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Rats; S100 Calcium Binding Protein beta Subunit | 2022 |
Tanshinone IIA alleviates the damage of neurocytes by targeting GLUT1 in ischaemia reperfusion model (in vivo and in vitro experiments).
Topics: Abietanes; Animals; Brain; Brain Ischemia; Disease Models, Animal; Glucose Transporter Type 1; Mice; Mice, Inbred C57BL; Neurons; Recovery of Function; Reperfusion Injury | 2020 |
Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axons; Brain Ischemia; Disease Models, Animal; Humans; Molecular Structure; Myosin Light Chains; Nogo Proteins; Nogo Receptor 1; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; rho-Associated Kinases; Salvia miltiorrhiza; Signal Transduction | 2020 |
A network-based method for mechanistic investigation and neuroprotective effect on treatment of tanshinone Ⅰ against ischemic stroke in mouse.
Topics: Abietanes; Animals; beta Catenin; Brain Ischemia; Cell Line; Cell Survival; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Hippocampus; Ischemic Stroke; Male; MAP Kinase Signaling System; Mice, Inbred ICR; Mitogen-Activated Protein Kinase Kinases; Molecular Docking Simulation; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Interaction Maps; Proto-Oncogene Proteins c-akt; raf Kinases | 2021 |
Borneol-modified tanshinone IIA liposome improves cerebral ischemia reperfusion injury by suppressing NF-κB and ICAM-1 expression.
Topics: Abietanes; Animals; Brain Ischemia; Camphanes; Intercellular Adhesion Molecule-1; Liposomes; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2021 |
Nose-to-brain delivery of borneol modified tanshinone IIA nanoparticles in prevention of cerebral ischemia/reperfusion injury.
Topics: Abietanes; Adjuvants, Pharmaceutic; Administration, Intranasal; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Brain Ischemia; Camphanes; Chemistry, Pharmaceutical; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Malondialdehyde; Nanoparticles; Neuroprotective Agents; Particle Size; Polyethylene Glycols; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Reperfusion Injury; Succinimides; Superoxide Dismutase | 2021 |
Tanshinone IIA improves hypoxic ischemic encephalopathy through TLR‑4‑mediated NF‑κB signal pathway.
Topics: Abietanes; Animals; Animals, Newborn; Blood-Brain Barrier; Brain Diseases; Brain Ischemia; Gene Expression Regulation; Mice; NF-kappa B; Toll-Like Receptor 4 | 2018 |
[Study on regulation of tanshinone II(A) on GFAP and ATPase and PDI of cerebral ischemia reperfusion injury in rats].
Topics: Abietanes; Adenosine Triphosphatases; Animals; Brain; Brain Ischemia; Disease Models, Animal; Glial Fibrillary Acidic Protein; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Protein Disulfide-Isomerases; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Rhizome; Salvia miltiorrhiza | 2012 |
The effect of cationic albumin-conjugated PEGylated tanshinone IIA nanoparticles on neuronal signal pathways and neuroprotection in cerebral ischemia.
Topics: Abietanes; Animals; Brain Ischemia; Cattle; Male; Nanoparticles; Neuroprotective Agents; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Signal Transduction | 2013 |
Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.
Topics: Abietanes; Alzheimer Disease; Animals; Anticonvulsants; Brain Ischemia; Disease Models, Animal; Disease Progression; Drugs, Chinese Herbal; Fertilization in Vitro; Injections, Intraventricular; Larva; Male; Medicine, Chinese Traditional; Mice; Microinjections; Neuroprotective Agents; Pentylenetetrazole; Plant Extracts; Plant Roots; Proto-Oncogene Proteins c-fos; Salvia miltiorrhiza; Seizures; Small Molecule Libraries; Zebrafish | 2013 |
Anti-inflammatory effect of tanshinone I in neuroprotection against cerebral ischemia-reperfusion injury in the gerbil hippocampus.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Drugs, Chinese Herbal; Gerbillinae; Hippocampus; Male; Neuroprotective Agents; Reperfusion Injury; Treatment Outcome | 2014 |
Neuroprotection via maintenance or increase of antioxidants and neurotrophic factors in ischemic gerbil hippocampus treated with tanshinone I.
Topics: Abietanes; Animals; Antioxidants; Blotting, Western; Brain Ischemia; Brain-Derived Neurotrophic Factor; Gerbillinae; Hippocampus; Immunohistochemistry; Insulin-Like Growth Factor I; Male; Nerve Growth Factors; Superoxide Dismutase; Superoxide Dismutase-1 | 2014 |
Tanshinone IIA attenuates the cerebral ischemic injury-induced increase in levels of GFAP and of caspases-3 and -8.
Topics: Abietanes; Animals; Blotting, Western; Brain Ischemia; Caspase 3; Caspase 8; Cell Death; Disease Models, Animal; Entorhinal Cortex; Glial Fibrillary Acidic Protein; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Random Allocation; Rats, Sprague-Dawley | 2015 |
Tanshinone IIA Elicits Neuroprotective Effect Through Activating the Nuclear Factor Erythroid 2-Related Factor-Dependent Antioxidant Response.
Topics: Abietanes; Animals; Antioxidants; Apoptosis; Brain Ischemia; Cell Nucleus; Gene Knockdown Techniques; Male; Mice, Knockout; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidation-Reduction; Protein Transport; Reperfusion Injury | 2017 |
Neuroprotective effects of Tanshinone IIA on permanent focal cerebral ischemia in mice.
Topics: Abietanes; Animals; Astrocytes; Brain; Brain Ischemia; Cells, Cultured; Cerebral Infarction; Drugs, Chinese Herbal; Hydrogen Peroxide; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Neuroprotective Agents; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Phenanthrenes; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2009 |
Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Blotting, Western; Brain Ischemia; Capillary Permeability; Claudin-5; Down-Regulation; Endothelial Cells; Gene Expression; HMGB1 Protein; Male; Membrane Proteins; Microscopy, Confocal; Neuroprotective Agents; NF-kappa B; Phenanthrenes; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; Toll-Like Receptor 4 | 2010 |
The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke.
Topics: Abietanes; Active Transport, Cell Nucleus; Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Drugs, Chinese Herbal; Humans; Male; Neuroprotective Agents; Neuropsychological Tests; Phenanthrenes; Rats; Rats, Sprague-Dawley; Stroke; Transcription Factors; Up-Regulation | 2010 |
[Effect of tanshinone IIA pretreatment on IL-1β and RelA mRNA expression in rats with focal cerebral ischemia].
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Brain Ischemia; Infarction, Middle Cerebral Artery; Interleukin-1beta; Male; Rats; Reperfusion Injury; RNA, Messenger; Transcription Factor RelA | 2010 |
Tanshinone IIA prevented brain iron dyshomeostasis in cerebral ischemic rats.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain Ischemia; Cation Transport Proteins; Hypoxia; Iron; Male; Membrane Proteins; Rats; Rats, Wistar; Receptors, Transferrin | 2011 |
Neuroprotection of tanshinone IIA against cerebral ischemia/reperfusion injury through inhibition of macrophage migration inhibitory factor in rats.
Topics: Abietanes; Animals; Antigens, Nuclear; Brain Ischemia; Cerebral Infarction; Glial Fibrillary Acidic Protein; Inflammation Mediators; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Male; Nerve Tissue Proteins; Neuroprotective Agents; Neutrophil Infiltration; Peroxidase; Protein Transport; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Time Factors; Transcription Factor RelA; Water | 2012 |
Neuroprotective effects of tanshinone IIA and/or tetramethylpyrazine in cerebral ischemic injury in vivo and in vitro.
Topics: Abietanes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Brain Ischemia; Calcium; Cerebral Cortex; Disease Models, Animal; Drug Therapy, Combination; Infarction, Middle Cerebral Artery; Male; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2012 |
Neutroprotective efficacy of sodium tanshinone B on hippocampus neuron in a rat model of focal cerebral ischemia.
Topics: Abietanes; Animals; Brain Ischemia; Cytoprotection; Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Hippocampus; Models, Biological; Neurons; Neuroprotective Agents; Random Allocation; Rats; Reperfusion Injury; Treatment Outcome | 2012 |
Protective effects of cationic bovine serum albumin-conjugated PEGylated tanshinone IIA nanoparticles on cerebral ischemia.
Topics: Abietanes; Animals; Brain; Brain Ischemia; Cattle; Drug Carriers; Gene Expression Regulation; Immunosuppressive Agents; Interleukin-1beta; Interleukin-6; Nanoparticles; p38 Mitogen-Activated Protein Kinases; Polyethylene Glycols; PPAR gamma; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Tumor Necrosis Factor-alpha | 2013 |
[Effects of sodium tanshinone B on the protein expression of NMDAR1 in rat hippocampal subfields following focal ischemia/reperfusion injury].
Topics: Abietanes; Animals; Brain Ischemia; Hippocampus; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury | 2012 |
Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice.
Topics: Abietanes; Animals; Anticoagulants; Brain Ischemia; Drugs, Chinese Herbal; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Phenanthrenes; Phytotherapy; Plant Extracts; Plant Roots; Salvia miltiorrhiza | 2003 |