tannins and Trichinellosis

The immune response of rats to infection with Trichinella spiralis was studied serially for more than 1 year. Initial antigen-specific cellular reactivity, assessed by the lymphocyte transformation response, developed in the draining mesenteric nodes 3 days after infection. After 1 week reactive lymphocytes were detectable in the spleen and circulating blood, but the more 'remote' peripheral nodes did not harbor antigen-reactive cells until late in the second week. Thereafter, the patterns of antigen-responsiveness varied among the different lymphoid pools, but in all cases a decline in reactivity was seen after the first month. Serum hemagglutinating and homocytotropic antibodies, detectable by the tenth day, reached their peaks after 1 month of infection. Hemagglutinating titers persisted for more than 1 year but homocytotropic antibody was lost over this period. Comparisons are drawn between the evolution of the natural infection and the development of the host's immune response.

Topics: Animals; Antibody Formation; Antigens; Blood Cells; Cells, Cultured; Erythrocytes; Hemagglutination Tests; Immunity, Cellular; Immunoglobulin G; Isoantibodies; Lymph Nodes; Lymphocyte Activation; Lymphocytes; Male; Passive Cutaneous Anaphylaxis; Rats; Rats, Inbred Lew; Sheep; Spleen; Tannins; Trichinella; Trichinellosis

Topics: Animals; Cattle; Erythrocytes; Female; Hemagglutination Tests; Immunization; Immunosuppression Therapy; Larva; Mice; Mice, Inbred C57BL; Povidone; Serum Albumin, Bovine; Sheep; Tannins; Tissue Extracts; Trichinella; Trichinellosis

Topics: Animals; Antibodies; Erythrocytes; Hemagglutination Tests; Humans; Mass Screening; Sheep; Tannins; Trichinellosis

Topics: Arthritis, Rheumatoid; Beta-Globulins; Blood Protein Electrophoresis; Centrifugation; Erythrocytes; gamma-Globulins; Hemagglutination; Hemagglutination Tests; Humans; Immune Sera; Research; Serum Globulins; Tannins; Trichinellosis