tannins and Thyroiditis

Topics: Animals; Antigens; Autoantibodies; Autoimmune Diseases; Epitopes; Female; Freund's Adjuvant; Germ-Free Life; Hemagglutination Tests; Pertussis Vaccine; Rats; Rats, Inbred Strains; Species Specificity; Tannins; Thyroid Gland; Thyroiditis

In vitro lymphocyte transformation to homologous thyroid antigen has been studied in cultures of lymph node cells obtained from 97 guinea pigs at weekly intervals after a single injection of homologous thyroid extract in complete Freund's adjuvant, using a method for measurement of 3-H-thymidine incorporation. Lymph node cell cultures from animals 1 week after sensitization showed a significant increase in thymidine incorporation after the addition of antigen. Two weeks after sensitization the stimulation was maximal, and then a lower but significant response continued during the next 5 weeks. There was no correlation between lymphocyte transformation and the level of circulating antibodies throughout the post-sensitization period examined. The early lymphocyte transformation contrasted with the later development of macrophage migration inhibitory factor activity.

Topics: Animals; Antibodies; Cell Migration Inhibition; Cells, Cultured; Female; Guinea Pigs; Hemagglutination Tests; Lymph Nodes; Lymphocyte Activation; Lymphocytes; Macrophage Migration-Inhibitory Factors; Macrophages; Tannins; Thymidine; Thyroiditis; Tissue Extracts; Tritium

Topics: Animals; Antibodies; Antigens; Autoimmune Diseases; Blood Cell Count; Bone Marrow Examination; Cytarabine; Guinea Pigs; Hemagglutination Tests; Immunization; Liver; Lymph Nodes; Male; Skin Tests; Spleen; Tannins; Thymus Gland; Thyroid Gland; Thyroiditis; Tissue Extracts

Topics: Animals; Antibodies; Antibody Formation; Antigen-Antibody Reactions; Chromatography, Gel; Erythrocytes; Hemagglutination Inhibition Tests; Hemagglutination Tests; Immune Sera; Immunodiffusion; Injections, Intravenous; Papain; Passive Cutaneous Anaphylaxis; Precipitin Tests; Rabbits; Tannins; Thyroglobulin; Thyroid Gland; Thyroiditis

Topics: Acrylates; Animals; Antigens; Electrophoresis; Erythrocytes; Ethylmaleimide; Gels; Glyoxylates; Guinea Pigs; Hemagglutination Tests; Hot Temperature; Humans; Imidazoles; Immune Sera; Immunochemistry; Immunodiffusion; Lipoproteins; Microscopy, Electron; Neuraminidase; Organ Specificity; Pepsin A; Peptide Hydrolases; Phospholipases; Sheep; Tannins; Thyroid Gland; Thyroiditis; Thyroiditis, Autoimmune; Trypsin; Ultrasonics; Venoms