tannins and Staphylococcal-Skin-Infections

Biofilms formed from the pathogenic bacteria that attach to the surfaces of biomedical devices and implantable materials result in various persistent and chronic bacterial infections, posing serious threats to human health. Compared to the elimination of matured biofilms, prevention of the formation of biofilms is expected to be a more effective way for the treatment of biofilm-associated infections. Herein, we develop a facile method for endowing diverse substrates with long-term antibiofilm property by deposition of a hybrid film composed of tannic acid/Cu ion (TA/Cu) complex and poly(ethylene glycol) (PEG). In this system, the TA/Cu complex acts as a multifunctional building block with three different roles: (i) as a versatile "glue" with universal adherent property for substrate modification, (ii) as a photothermal biocidal agent for bacterial elimination under irradiation of near-infrared (NIR) laser, and (iii) as a potent linker for immobilization of PEG with inherent antifouling property to inhibit adhesion and accumulation of bacteria. The resulted hybrid film shows negligible cytotoxicity and good histocompatibility and could prevent biofilm formation for at least 15 days

Topics: Animals; Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Biofouling; Cell Line; Coated Materials, Biocompatible; Copper; Escherichia coli; Infrared Rays; Male; Mice; Microbial Sensitivity Tests; Photothermal Therapy; Polyethylene Glycols; Rats, Sprague-Dawley; Skin; Staphylococcal Skin Infections; Staphylococcus aureus; Tannins