tannins and Renal-Insufficiency--Chronic

This study investigated the chemical and nutritional composition of breakfast cereal based on whole sorghum, and the effect of its association with unfermented probiotic milk on the inflammation and oxidative stress of individuals with chronic kidney disease. Extruded sorghum breakfast meal presented higher carbohydrate concentration (approximately 71%), followed by protein (approximately 11%) and lipid (approximately 0.4%). When compared to extruded maize breakfast meal, it presented higher percentage of dietary fiber (p < 0.05), and higher content of phenolic compounds and tannin, consequently higher antioxidant activity (p < 0.05). Extruded sorghum breakfast cereal combined with unfermented probiotic milk decreased the C-reactive protein (p < 0.05) and malondialdehyde (p < 0.05) serum levels and increased the total antioxidant capacity and superoxide dismutase (p < 0.05) in patients with chronic kidney disease. Therefore, the extruded sorghum, source of tannin, anthocyanin, and dietary fiber, when consumed with unfermented probiotic milk alleviates the inflammation and oxidative stress in patients with chronic kidney disease.

Topics: Animals; Anthocyanins; Biomarkers; Brazil; Breakfast; C-Reactive Protein; Dietary Fiber; Edible Grain; Food Microbiology; Humans; Inflammation Mediators; Malondialdehyde; Milk; Nutritive Value; Oxidative Stress; Probiotics; Renal Insufficiency, Chronic; Sorghum; Superoxide Dismutase; Tannins; Treatment Outcome