tannins and Periodontal-Diseases

Topics: Acrylates; Animals; Antifungal Agents; Calcium; Dental Instruments; Dental Materials; Gingivectomy; Gingivoplasty; Humans; Methods; Occlusive Dressings; Oils; Oils, Volatile; Periodontal Diseases; Rabbits; Resins, Plant; Subgingival Curettage; Sulfates; Tannins; Tissue Adhesives; Zinc Oxide-Eugenol Cement

Reactive oxygen species have been implicated as important pathological mediators in many clinical disorders, including periodontal disease. As a possible alternative for the treatment of periodontal disease, the antimicrobial activity of six tannins isolated from Vaccinium vitis-idaea L., with confirmed antioxidant activity, were assayed by the agar dilution method against selected periodontal pathogens, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia. The results showed that epicatechin-(4beta-->8)-epicatechin-(4beta-->8, 2beta-->O-->7)-catechin had strong antimicrobial activity against P. gingivalis and P. intermedia, but not A. actinomycetemcomitans. The other tannins tested did not show antimicrobial activity. We conclude that tannins isolated from V. vitis-idaea L. with antimicrobial activity could potentially be used for the treatment of periodontal disease.

Topics: Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Antioxidants; Humans; Microbial Sensitivity Tests; Periodontal Diseases; Plants, Medicinal; Porphyromonas gingivalis; Prevotella intermedia; Tannins

Reactive oxygen molecules have been implicated as important pathological mediators in many clinical disorders and periodontal disease. To provide possible alternative treatment of periodontal disease, six tannins isolated from Vaccinium vitis-idaea L. were evaluated for anti-lipid peroxidation, anti-superoxide formation and free radical scavenging activity. The results showed that cinnamtannin B1 displayed the strongest anti-lipid peroxidation activity, proanthocyanidin A-1 displayed the strongest superoxide scavenging activity, and epicatechin-(4beta--> 6)-epicatechin-(4beta-->8, 2beta-->O--> 7)-catechin had the strongest anti-superoxide formation effect. We conclude that tannins isolated from V. vitis-idaea L. exhibited multiple antioxidant activity, and could be used for the treatment of periodontal disease.

Topics: Antioxidants; Lipid Peroxidation; Periodontal Diseases; Plant Extracts; Reactive Oxygen Species; Structure-Activity Relationship; Superoxides; Tannins; Xanthine Oxidase

Topics: Adolescent; Antibodies; Antibodies, Anti-Idiotypic; Arthritis; Child; Geriatrics; Heart Diseases; Hemagglutination; Humans; Nephritis; Periodontal Diseases; Rheumatic Fever; Rheumatic Heart Disease; Scarlet Fever; Streptococcal Infections; Streptococcus; Tannins; Thyroid Diseases