tannins and Peptic-Ulcer

This review of the current literature aims to study correlations between the chemical structure and gastric anti-ulcer activity of tannins. Tannins are used in medicine primarily because of their astringent properties. These properties are due to the fact that tannins react with the tissue proteins with which they come into contact. In gastric ulcers, this tannin-protein complex layer protects the stomach by promoting greater resistance to chemical and mechanical injury or irritation. Moreover, in several experimental models of gastric ulcer, tannins have been shown to present antioxidant activity, promote tissue repair, exhibit anti Helicobacter pylori effects, and they are involved in gastrointestinal tract anti-inflammatory processes. The presence of tannins explains the anti-ulcer effects of many natural products.

Topics: Anti-Bacterial Agents; Anti-Ulcer Agents; Helicobacter Infections; Helicobacter pylori; Humans; Peptic Ulcer; Phytochemicals; Plant Extracts; Structure-Activity Relationship; Tannins

Phytogenic agents have traditionally been used by herbalists and indigenous healers for the prevention and treatment of peptic ulcer. This article reviews the anti-acid/anti-peptic, gastro-protective and/or anti-ulcer properties of the most commonly employed herbal medicines and their identified active constituents. Botanical compounds with anti-ulcer activity include flavonoids (i.e. quercetin, naringin, silymarin, anthocyanosides, sophoradin derivatives) saponins (i.e. from Panax japonicus and Kochia scoparia), tannins (i.e. from Linderae umbellatae), gums and mucilages (i.e. gum guar and myrrh). Among herbal drugs, liquorice, aloe gel and capsicum (chilli) have been used extensively and their clinical efficacy documented. Also, ethnomedical systems employ several plant extracts for the treatment of peptic ulcer. Despite progress in conventional chemistry and pharmacology in producing effective drugs, the plant kingdom might provide a useful source of new anti-ulcer compounds for development as pharmaceutical entities or, alternatively, as simple dietary adjuncts to existing therapies.

Topics: Aloe; Capsicum; Flavanones; Flavonoids; Gingiva; Glycyrrhiza; Humans; Peptic Ulcer; Phytotherapy; Plants, Medicinal; Quercetin; Saponins; Silymarin; Tannins

Ouren-Gedoku-To (OGT) and San'ou-Syashin-To (SST), traditional Chinese prescriptions, have been used to treat peptic ulcer. In order to elucidate the mechanism of the protective effects of OGT and SST on the gastric mucosa, we studied their effects on gastric mucosal lesions, ion permeability and prostaglandin synthesis using ulcer experimentally induced in rats by saturation with acidic test solution after taurocholate treatment. Both OGT and SST inhibited taurocholate-induced gastric mucosal lesions in a dose-related manner. These prescriptions dose-dependently inhibited not only the increase of hydrogen and sodium ion net fluxes but also possible hydrogen ion back diffusion into the gastric mucosa during saturation with acidic test solution. SST induced a significant increase in gastric mucosal prostaglandins synthesized from 14C labeled arachidonate. These results suggest that both OGT and SST by strengthening the gastric mucosal barrier demonstrate their protective effects on the gastric mucosa and that this effect of SST is attributable to the increased ability of the gastric mucosa to synthesize prostaglandin.

Topics: Animals; Anti-Ulcer Agents; Berberine; Drug Combinations; Drugs, Chinese Herbal; Flavonoids; Gastric Mucosa; In Vitro Techniques; Male; Peptic Ulcer; Plant Extracts; Prostaglandins; Protons; Rats; Rats, Inbred Strains; Tannins

Topics: Animal Nutritional Physiological Phenomena; Animals; Dose-Response Relationship, Drug; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Ligation; Male; Mucins; Nutrition Disorders; Pepsin A; Peptic Ulcer; Pylorus; Rats; Stomach; Tannins; Time Factors

Topics: Adolescent; Adult; Alcoholism; Antibodies; Antibody Formation; Antigens; Bronchitis; Child; Child, Preschool; Chromatography, Gel; Chronic Disease; Coronary Disease; Diabetes Mellitus; Erythrocytes; Female; Flagella; Hemagglutination Tests; Humans; Immunization, Secondary; Infant; Isoantibodies; Male; Mercaptoethanol; Multiple Myeloma; Peptic Ulcer; Postgastrectomy Syndromes; Salmonella; Tannins

Topics: Adult; Anesthetics; Atropa belladonna; Gastrointestinal Diseases; Glycyrrhiza; Humans; Peptic Ulcer; Phytotherapy; Plants, Medicinal; Plants, Toxic; Tannins

Topics: Cholecystitis; Gastroenteritis; Humans; Hydrolyzable Tannins; Mucous Membrane; Peptic Ulcer; Silver Proteins; Tannins

Topics: Benzoates; Herbicides; Peptic Ulcer; Plant Poisoning; Plants; Stomach Ulcer; Tannins

Topics: Adrenal Glands; Animals; Hypothalamus; Peptic Ulcer; Pituitary Gland; Rats; Stomach Ulcer; Tannins