tannins and Keratitis

Bacterial keratitis (BK) and related inflammatory diseases causes irreversible damage to the corneal tissue. In this study, a novel polyacrylamide semi-interpenetrating network hydrogel including quaternized chitosan and tannic acid (PAM-QCS-TA) were used to construct a novel antibacterial and antioxidant contact lens. The obtained hydrogels showed high water content (>85%), swelling resistance, light transmittance (>90%) and adjustable mechanical property. Both quantitative and qualitative antibacterial experiments against Staphylococcus aureus and Escherichia coli (E. coli) indicated excellent sterilization function especially against E. coli (almost 100%). Due to the presence of tannin acid, it showed obvious antioxidant properties, which relieved oxidative stress and protect cells from reactive oxygen species-induced cytotoxicity. Animal experiments also indicated the shortened treatment time of BK (only 3 days) as well as the protection of eye tissue structure. Therefore, such drug-free antibacterial and antioxidant contact lens avoiding the development of drug resistance is a potential candidate in ocular infectious and inflammatory diseases treatment.

Topics: Animals; Anti-Bacterial Agents; Chitosan; Contact Lenses; Escherichia coli; Hydrogels; Keratitis; Tannins

Topics: Animals; Anti-Bacterial Agents; Cobalt; Eye Infections, Bacterial; Gelatin; Hydrogels; Keratitis; Mice; Ophthalmic Solutions; Oxides; Peroxidases; Pseudomonas aeruginosa; Pseudomonas Infections; Tannins