tannins and Hypersensitivity

Asthma is a chronic inflammatory disease of the airways, which is characterized by infiltration of inflammatory cells, airway hyperresponsiveness (AHR), and airway remodeling. This study aimed to explore the role and mechanism of tannic acid (TA), a naturally occurring plant-derived polyphenol, in murine asthma model. BALB/c mice were given ovalbumin (OVA) to establish an allergic asthma model. The results revealed that TA treatment significantly decreased OVA-induced AHR, inflammatory cells infiltration, and the expression of various inflammatory mediators (Th2 and Th1 cytokines, eotaxin, and total IgE). Additionally, TA treatment also attenuated increases in mucins (Muc5ac and Muc5b) expression, mucus production in airway goblet cells, mast cells infiltration, and airway remodeling induced by OVA exposure. Furthermore, OVA-induced NF-κB (nuclear factor- kappa B) activation and cell adhesion molecules expression in the lungs was suppressed by TA treatment. In conclusion, TA effectively attenuated AHR, inflammatory response, and airway remodeling in OVA-challenged asthmatic mice. Therefore, TA may be a potential therapeutic option against allergic asthma in clinical settings.

Topics: Airway Remodeling; Allergens; Animals; Asthma; Disease Models, Animal; Female; Humans; Hypersensitivity; Mice; Mucins; Nuts; Respiratory Hypersensitivity; Tannins; Th1 Cells; Th2 Cells

The anti-allergenicity of phlorotannin-targeted extracts from four edible seaweed species of Fucus genus was evaluated herein for the first time. Extracts were able to act upon cellular events triggered by immunological reaction (IgE/antigen), and on cellular events downstream the Ca

Topics: Animals; Anti-Allergic Agents; Cell Degranulation; Cell Line; Fucus; Histamine; Hyaluronoglucosaminidase; Hypersensitivity; Immunoglobulin E; Mast Cells; Plant Extracts; Seaweed; Tannins

Topics: Adolescent; Adult; Aged; Asthma; Blood Proteins; Glycoproteins; Humans; Hypersensitivity; Middle Aged; Neuraminic Acids; Tannins

Topics: Animals; Antibodies; Antigens; Ascariasis; Ascaris; Body Fluids; Erythrocytes; Hemagglutination; Hemagglutination Tests; Humans; Hypersensitivity; Intestines; Tannins

Topics: Animals; Antibodies; Antigens; Ascariasis; Ascaris; Body Fluids; Duodenum; Erythrocytes; Hemagglutination; Hemagglutination Tests; Humans; Hypersensitivity; Stomach; Tannins

Topics: Humans; Hypersensitivity; Immune System Diseases; Tannins

Topics: Desensitization, Immunologic; Humans; Hypersensitivity; Pollen; Tannins

Topics: Asthma; Gallic Acid; Humans; Hydrolyzable Tannins; Hypersensitivity; Immune System Diseases; Rhinitis, Allergic; Tannins; Urticaria

Topics: Anaphylaxis; Hypersensitivity; Immune System Diseases; Intestines; Tannins