tannins and Eczema

The aim of the present study was to investigate the relation between the content of Cr(VI) and soluble Cr(III) in leather and the ability of the leather to elicit eczema in chromium allergic patients. An array of chromium-tanned leather samples was analysed for the content of total Cr(VI) and soluble Cr(III) using the DIN 53314 and the DS/EN 420 methods. Subsequently, a group of 15 patients with a history of foot eczema and leather exposure was exposed to a selection of 14 chromium- and 1 vegetable-tanned leather sample on the upper back for 48 hr. In addition, one leather sample was used for a prolonged 14-day exposure study. In total, 4 of the 15 patients reacted to at least one leather sample, and 5 of the 14 leather samples elicited a reaction in at least 1 patient. The prolonged exposure study demonstrated that an extended exposure period may reveal allergenic potential of a leather sample not otherwise identified using an ordinary 48-hr exposure period. No relation was observed between the measured content of Cr(VI) and soluble Cr(III) in the leather and the elicitation of eczema. Thus, in order to evaluate the quality of chromium-tanned leather in relation to preventing allergic skin reactions, other more clinical relevant methods reflecting the actual bioavailable Cr(III) and Cr(VI) fractions should be developed.

Topics: Chromium Compounds; Dermatitis, Allergic Contact; Eczema; Foot Dermatoses; Humans; Ions; Patch Tests; Shoes; Tannins

The treatment of the different diseases which are comprised under the determination of "eczema" is mainly an anti-inflammatory treatment. Thus, topical corticosteroids play a large role. Development of more potent topical corticosteroids has lead to increasing numbers of unwanted side effects. In local therapy of eczema it is important to consider the phase of the disease when one chooses the vehicle: wet dressings, lotions, creams or ointments are applied according to the actual state of the skin. Special localisations also have to be considered e.g. in scrotal or perianal exzema.

Topics: Administration, Topical; Adrenal Cortex Hormones; Anti-Bacterial Agents; Coal Tar; Dosage Forms; Drug Combinations; Eczema; Humans; Mineral Oil; Plant Extracts; Tannins

Topics: Alginates; Allergens; Aluminum; Ammonium Sulfate; Calcium; Chlortetracycline; Coloring Agents; Eczema; Flavoring Agents; Food Additives; Food Preservation; Humans; Iodates; Lanolin; Nickel; Parabens; Potassium; Resins, Plant; Stearic Acids; Sulfates; Tannins; Thiosulfates; Waxes

Topics: Burns; Data Collection; Dermatology; Eczema; History; Humans; Tannins