tannins and Celiac-Disease

Celiac Disease (CD) is now recognized as a worldwide epidemic. Although a gluten free diet usually induces clinical improvements within days or weeks, adhering to this routine is still troublesome. Therefore, new solutions are needed for quality-of-life improvement of CD patients. The present work intends to bring molecular and thermodynamic insights on the ability of green tea epigalhocatechin-3-gallate (EGCG) to interact and modulate the bioavailability of a major CD immunodominant peptide (32-mer). Characterization of peptide binding was assessed by means of both 1D and 2D

Topics: Caco-2 Cells; Calorimetry; Catechin; Celiac Disease; Humans; Molecular Conformation; Molecular Dynamics Simulation; Peptides; Proton Magnetic Resonance Spectroscopy; Tannins; Thermodynamics