tannins and Burns

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aged; Aminobenzoates; Animals; Burns; Burns, Chemical; Burns, Electric; Child; Colloids; Debridement; Diuretics; Dogs; Electrolytes; Environmental Exposure; Gentamicins; Granulation Tissue; Humans; Kidney Function Tests; Male; Plasma; Procaine; Prostheses and Implants; Respiration; Silver Nitrate; Skin Transplantation; Sulfonic Acids; Tannins; Transplantation, Autologous; Transplantation, Heterologous; Transplantation, Homologous; Water-Electrolyte Balance; Wound Healing; Wound Infection

Topics: Burns; Humans; Hydrolyzable Tannins; Membranes, Artificial; Tannins

The influence of toxic factors from burned skin on pathogenesis of burn disease has been demonstrated in recent years. For preparation for skin transplantation synthetic material is used. The present study was undertaken to investigate if such material could inhibit the resorption of toxic factors. Specific mitochondrial alterations, which are reproducibly found 5 days after skin burn or application of burn toxin, served as parameter. Rats, which were treated shortly after burn or later with tannic acid were used as controls. Glucose and urea were measured in serum to check the synthetic function. Therapy with Epigard resulted in a better general condition and normal values of glucose and urea, but no reduction of specific mitochondrial alterations. Treatment with tannic acid caused no improvement in general condition, glucose and urea levels were not significantly altered. Only the early application resulted in a reduction of mitochondrial alterations. An otherwise indicated therapy with a synthetic skin material is not suitable for inhibition of the resorption of toxic factors from burnt skin.

Topics: Animals; Blood Glucose; Burns; Female; Fluorocarbon Polymers; Hydrolyzable Tannins; Microscopy, Electron; Mitochondria, Liver; Rats; Skin Absorption; Tannins; Uric Acid

Topics: Alanine Transaminase; Animals; Burns; Plants, Medicinal; Rats; Tannins

Topics: Adult; Burns; Drug Therapy, Combination; Humans; Hydrolyzable Tannins; Male; Mercury; Mercury Poisoning; Silver Nitrate; Tannins

We describe the in situ production of a burn wound dressing applied to eschar that completely isolates burned tissue from contamination with Pseudomonas aeruginosa. Anesthetized, adult rats were subjected to a scald burn over 10% of their body surfaces. One-half hour later a test dressing presumed to be a barrier to bacterial contamination of the wound was applied to the burned surface. Tannic acid, vaseline, ethyl linoleate, collodion, and polyhydroxethylmethacrylate (PHEMA) were evaluated. Each agent was applied directly to the burned surface. A solid film of the PHEMA was produced on the eschar by addition of solvent and a powdered form of the polymer. The surface of each synthetic dressing was contaminated 30 min after application by the addition of 10(8) P. aeruginosa. Also, a control set of rats was burned and their eschars were directly contaminated without application of the test dressing. Seven days later the contaminated muscle under the burned area in 10 control rats had P. aeruginosa counts of 10(7) to 10(8) per g of muscle (wet weight). Of the materials tested, only PHEMA consistently acted as an effective barrier dressing, reducing bacteria in the muscle to undetectable levels in 11 of 14 tests. It was also possible to treat contaminated eschar through this synthetic dressing by topical application of antibiotics to the barrier surface. The results suggest a novel clinical approach in which a barrier dressing could be used to isolate a burn eschar from environmental and subject contamination until the wound site is ready for grafting.

Topics: Acrylic Resins; Animals; Burns; Collodion; Linoleic Acids; Occlusive Dressings; Petrolatum; Polyethylene Glycols; Polymethacrylic Acids; Pseudomonas aeruginosa; Pseudomonas Infections; Rats; Tannins; Wound Infection

Topics: Animals; Ascorbic Acid; Burns; Colorimetry; Flavonoids; Kidney; Liver; Muscles; Rats; Tannins; Time Factors

Topics: Acid Phosphatase; Adrenal Glands; Alkaline Phosphatase; Animals; Ascorbic Acid; Blood Glucose; Blood Proteins; Burns; Flavonoids; Glycogen; Guinea Pigs; Hydrolyzable Tannins; L-Lactate Dehydrogenase; Liver; Muscles; Nucleic Acids; Pyruvates; Succinate Dehydrogenase; Tannins; Time Factors

Topics: Adenosine Triphosphate; Animals; Ascorbic Acid; Burns; Carbohydrate Metabolism; Dermatologic Agents; Glycogen; Liver; Muscles; Phosphorus; Pyruvates; Rats; Steam; Tannins; Time Factors

Topics: Burns; Drug Therapy; Gentian Violet; History, 18th Century; History, 19th Century; History, 20th Century; History, Ancient; History, Medieval; History, Modern 1601-; Humans; Paraffin; Pseudomonas Infections; Sulfonamides; Tannins; United Kingdom; United States; Wound Infection

Topics: Burns; Dermatitis; Dermatomycoses; History, 20th Century; Humans; Intertrigo; Skin Diseases; Sunburn; Sweating; Tannins

Topics: Animals; Anti-Infective Agents, Local; Burns; Cathepsins; Child; Child, Preschool; Humans; Infant; Kidney; Liver; Methods; Pepsin A; Rats; Silver Nitrate; Tannins; Trypsin

Topics: Burns; Chemical and Drug Induced Liver Injury; Humans; Tannins

Topics: Adolescent; Adult; Aged; Ascorbic Acid; Bandages; Burns; Child; Child, Preschool; England; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Outpatient Clinics, Hospital; Sweden; Tannins

Topics: Anti-Infective Agents, Local; Burns; Coloring Agents; Halothane; Humans; Mercury Compounds; Silver Nitrate; Tannins

Topics: Burns; Data Collection; Dermatology; Eczema; History; Humans; Tannins

Topics: Benzopyrans; Burns; Humans; Liver; Tannins

Topics: Burns; Humans; Tannins

Topics: Benzopyrans; Burns; Humans; Liver; Tannins

Topics: Benzopyrans; Burns; Humans; Tannins

Topics: Burns; Child; Humans; Tannins

Topics: Burns; Kidney; Liver; Tannins

Topics: Burns; Humans; Tannins