talotrexin has been researched along with Carcinoma, Squamous Cell in 5 studies
*Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cherian, C; Deng, Y; Desmoulin, SK; Gangjee, A; Hou, Z; Kushner, J; Matherly, LH; Polin, L; Wang, L; White, K; Wu, J | 1 |
| Chen, G; Rosowsky, A; Wright, JE | 1 |
| Holden, SA; Northey, D; Robinson, MF; Rosowsky, A; Teicher, BA | 1 |
| Bader, H; Rosowsky, A; Teicher, BA; Vaidya, CM; Wright, JE | 1 |
| Alperin, WL; Pardo, M; Rosowsky, A; Tretyakov, A; Trites, D; Wright, JE | 1 |
5 other study(ies) available for talotrexin and Carcinoma, Squamous Cell
| Article | Year |
|---|---|
Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduc
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Carrier Proteins; Cell Proliferation; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Female; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Humans; Membrane Transport Proteins; Mice; Mice, Inbred ICR; Mice, SCID; Ovarian Neoplasms; Proton-Coupled Folate Transporter; Purines; Pyrimidines; Receptors, Cell Surface; Reduced Folate Carrier Protein | 2010 |
Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Kinetics; Methotrexate; Ornithine; Pterins; Pteroylpolyglutamic Acids; Quinazolines; Tetrahydrofolate Dehydrogenase; Tritium; Tumor Cells, Cultured | 1995 |
Antifolates can potentiate topoisomerase II inhibitors in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Cell Line; Cell Survival; DNA Damage; DNA, Neoplasm; Drug Synergism; Etoposide; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Male; Methotrexate; Mice; Mice, Inbred C3H; Novobiocin; Ornithine; Pterins; Topoisomerase II Inhibitors; Trimetrexate; Tumor Cells, Cultured | 1995 |
Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Glutamates; Humans; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Molecular Structure; Ornithine; Pterins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1997 |
Pharmacokinetics, antifolate activity and tissue distribution of PT523 in SCC VII tumor-bearing mice.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Carbon Radioisotopes; Carcinoma, Squamous Cell; Folic Acid Antagonists; Injections, Intravenous; Isotope Labeling; Male; Methotrexate; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Ornithine; Pterins; Tetrahydrofolates; Tissue Distribution | 1998 |