talactoferrin alfa has been researched along with Blood Poisoning in 4 studies
talactoferrin alfa: recombinant human lactoferrin, an oral drug for treatment of refractory solid tumors; in Phase I trial 5/2006
| Excerpt | Relevance | Reference |
|---|---|---|
| "Administration of oral talactoferrin was not associated with reduced 28-day mortality in patients with severe sepsis and may even be harmful." | 9.20 | Talactoferrin in Severe Sepsis: Results From the Phase II/III Oral tAlactoferrin in Severe sepsIS Trial. ( Dellinger, RP; Guntupalli, K; Levy, MM; Malik, R; Marshall, JC; Simonson, SG; Singer, M; Vincent, JL, 2015) |
| "Enteral administration of talactoferrin reduced 28-day all-cause mortality in patients with severe sepsis." | 9.17 | A phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of talactoferrin in patients with severe sepsis. ( Bandi, V; Dean, N; Dellinger, RP; Guntupalli, K; Ismail, PM; Levy, M; Lodato, RF; Malik, R; Margolis, B; Morris, PE; Reese, A; Rivers, E; Schaumberg, JP, 2013) |
| "Administration of oral talactoferrin was not associated with reduced 28-day mortality in patients with severe sepsis and may even be harmful." | 5.20 | Talactoferrin in Severe Sepsis: Results From the Phase II/III Oral tAlactoferrin in Severe sepsIS Trial. ( Dellinger, RP; Guntupalli, K; Levy, MM; Malik, R; Marshall, JC; Simonson, SG; Singer, M; Vincent, JL, 2015) |
| "Enteral administration of talactoferrin reduced 28-day all-cause mortality in patients with severe sepsis." | 5.17 | A phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of talactoferrin in patients with severe sepsis. ( Bandi, V; Dean, N; Dellinger, RP; Guntupalli, K; Ismail, PM; Levy, M; Lodato, RF; Malik, R; Margolis, B; Morris, PE; Reese, A; Rivers, E; Schaumberg, JP, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guntupalli, K | 2 |
| Dean, N | 1 |
| Morris, PE | 1 |
| Bandi, V | 1 |
| Margolis, B | 1 |
| Rivers, E | 1 |
| Levy, M | 1 |
| Lodato, RF | 1 |
| Ismail, PM | 1 |
| Reese, A | 1 |
| Schaumberg, JP | 1 |
| Malik, R | 2 |
| Dellinger, RP | 2 |
| McCulloh, R | 1 |
| Opal, SM | 1 |
| Vincent, JL | 1 |
| Marshall, JC | 1 |
| Simonson, SG | 1 |
| Levy, MM | 1 |
| Singer, M | 1 |
| Sherman, MP | 1 |
| Adamkin, DH | 1 |
| Niklas, V | 1 |
| Radmacher, P | 1 |
| Sherman, J | 1 |
| Wertheimer, F | 1 |
| Petrak, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2 Randomized, Double-blind, Placebo-controlled Study of the Safety and Efficacy of Talactoferrin Alfa in Patients With Severe Sepsis[NCT00630656] | Phase 2 | 190 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| OASIS: A Phase 2/3 Randomized, Double-blind, Placebo-controlled Study of the Safety and Efficacy of Talactoferrin Alfa in Patients With Severe Sepsis[NCT01273779] | Phase 2/Phase 3 | 1,280 participants (Anticipated) | Interventional | 2011-06-30 | Suspended (stopped due to Data Safety Monitoring Board recommendation) | ||
| Phase 1/2 Study of Talactoferrin Oral Solution for Nosocomial Infection in Preterm Infants[NCT00854633] | Phase 1/Phase 2 | 120 participants (Anticipated) | Interventional | 2009-06-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for talactoferrin alfa and Blood Poisoning
| Article | Year |
|---|---|
A phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of talactoferrin in patients with severe sepsis.
Topics: Adult; Aged; APACHE; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hospital Mortali | 2013 |
Talactoferrin in Severe Sepsis: Results From the Phase II/III Oral tAlactoferrin in Severe sepsIS Trial.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; APACHE; Double-Blind Method; Female; Humans; | 2015 |
Randomized Controlled Trial of Talactoferrin Oral Solution in Preterm Infants.
Topics: Administration, Oral; Bacteremia; Cross Infection; Double-Blind Method; Enterocolitis, Necrotizing; | 2016 |
1 other study available for talactoferrin alfa and Blood Poisoning
| Article | Year |
|---|---|
Human recombinant lactoferrin for sepsis: too good to be true?.
Topics: Female; Humans; Lactoferrin; Male; Sepsis | 2013 |