tagitinin and Glioblastoma

tagitinin has been researched along with Glioblastoma* in 2 studies

Other Studies

2 other study(ies) available for tagitinin and Glioblastoma

Article	Year
Tithonia diversifolia and its main active component tagitinin C induce survivin inhibition and G2/M arrest in human malignant glioblastoma cells. Fitoterapia, 2011, Volume: 82, Issue:3 We investigated the antitumour activity of Tithonia diversifolia (TD) on malignant glioblastoma cells. Our results suggested that tagitinin C was the main component in viability inhibition on malignant glioblastoma cells, and also accounted to be the most abundant component (>65%) in TD extract. Both TD extract and tagitinin C exhibited vigorous potential to produce in vitro viability inhibition, autophagic cell death and G2/M arrest. Furthermore, the activity of survivin, a critical resistant-factor in cancer therapy, could be downregulated significantly by TD extract and tagitinin C. These findings suggested that TD extract and tagitinin C were effective for treating malignant glioblastoma. Topics: Antineoplastic Agents, Phytogenic; Asteraceae; Autophagy; Cell Cycle; Cell Line, Tumor; Cell Survival; Down-Regulation; Glioblastoma; Humans; Inhibitor of Apoptosis Proteins; Phytotherapy; Plant Extracts; Sesquiterpenes; Survivin	2011
Identification and anti-human glioblastoma activity of tagitinin C from Tithonia diversifolia methanolic extract. Journal of agricultural and food chemistry, 2011, Mar-23, Volume: 59, Issue:6 The Tithonia diversifolia methanolic extract (TDM), which showed antiproliferative activity against human glioblastoma U373 cells, with an IC50 value of 59.2±3.7 μg mL(-1), was passed through silica gel chromatography and successively eluted with different percentages of EtOAc/hexane. The 10-60% EtOAc/hexane subfractions, which exhibited a comparatively higher antiproliferative activity, were isolated, and then structural identification was proceeded with 1H nuclear magnetic resonance. The isolated compound was tagitinin C, a kind of sesquiterpenoid. The IC50 value was 6.1±0.1 μg mL(-1) in U373 treated with tagitinin C. In flow cytometric analysis and inhibition of pan-caspase, the results showed that the anti-glioblastoma effect was apoptosis-independent. In PARP, p-p38, ULK1, and LC3-II expression, the anti-glioblastoma induced by tagitinin C was likely via autophagy. In the ULK1 siRNA transfection experiment, autophagy blockade counteracted the suppression induced by tagitinin C. The result suggested that tagitinin C induces U373 cell death dependent upon autophagy under certain conditions. Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Asteraceae; Autophagy; Cell Line, Tumor; Glioblastoma; Humans; Methanol; Plant Extracts; Sesquiterpenes	2011

Article

Year

Tithonia diversifolia and its main active component tagitinin C induce survivin inhibition and G2/M arrest in human malignant glioblastoma cells.

Fitoterapia, 2011, Volume: 82, Issue:3

We investigated the antitumour activity of Tithonia diversifolia (TD) on malignant glioblastoma cells. Our results suggested that tagitinin C was the main component in viability inhibition on malignant glioblastoma cells, and also accounted to be the most abundant component (>65%) in TD extract. Both TD extract and tagitinin C exhibited vigorous potential to produce in vitro viability inhibition, autophagic cell death and G2/M arrest. Furthermore, the activity of survivin, a critical resistant-factor in cancer therapy, could be downregulated significantly by TD extract and tagitinin C. These findings suggested that TD extract and tagitinin C were effective for treating malignant glioblastoma.

Topics: Antineoplastic Agents, Phytogenic; Asteraceae; Autophagy; Cell Cycle; Cell Line, Tumor; Cell Survival; Down-Regulation; Glioblastoma; Humans; Inhibitor of Apoptosis Proteins; Phytotherapy; Plant Extracts; Sesquiterpenes; Survivin

2011

Identification and anti-human glioblastoma activity of tagitinin C from Tithonia diversifolia methanolic extract.

Journal of agricultural and food chemistry, 2011, Mar-23, Volume: 59, Issue:6

The Tithonia diversifolia methanolic extract (TDM), which showed antiproliferative activity against human glioblastoma U373 cells, with an IC50 value of 59.2±3.7 μg mL(-1), was passed through silica gel chromatography and successively eluted with different percentages of EtOAc/hexane. The 10-60% EtOAc/hexane subfractions, which exhibited a comparatively higher antiproliferative activity, were isolated, and then structural identification was proceeded with 1H nuclear magnetic resonance. The isolated compound was tagitinin C, a kind of sesquiterpenoid. The IC50 value was 6.1±0.1 μg mL(-1) in U373 treated with tagitinin C. In flow cytometric analysis and inhibition of pan-caspase, the results showed that the anti-glioblastoma effect was apoptosis-independent. In PARP, p-p38, ULK1, and LC3-II expression, the anti-glioblastoma induced by tagitinin C was likely via autophagy. In the ULK1 siRNA transfection experiment, autophagy blockade counteracted the suppression induced by tagitinin C. The result suggested that tagitinin C induces U373 cell death dependent upon autophagy under certain conditions.

Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Asteraceae; Autophagy; Cell Line, Tumor; Glioblastoma; Humans; Methanol; Plant Extracts; Sesquiterpenes

2011