tae226 and Neuroblastoma

Neuroblastoma is one of the most devastating pediatric solid tumors and is unresponsive to many interventions. TAE226 is a novel small molecule FAK inhibitor. We investigated the effects of TAE226 on neuroblastoma cells in vitro.. Human neuroblastoma cell lines were treated with varying concentrations of TAE226. Following treatment, cell viability, cell cycle, and apoptosis were evaluated.. Treatment of human neuroblastoma cell lines with TAE226 resulted in a concentration dependent decrease in FAK phosphorylation, decrease in cellular viability, cell cycle arrest, and an increase in apoptosis.. Targeting FAK provides potential therapeutic options for the treatment of neuroblastoma and deserves further investigation.

Topics: Apoptosis; Cell Cycle; Cell Proliferation; Focal Adhesion Kinase 1; Humans; Morpholines; Neuroblastoma; Phosphorylation; Tumor Cells, Cultured