tae226 and Lymphoma--Large-Cell--Anaplastic

tae226 has been researched along with Lymphoma--Large-Cell--Anaplastic* in 1 studies

Other Studies

1 other study(ies) available for tae226 and Lymphoma--Large-Cell--Anaplastic

Article	Year
Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models. Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1 The synthesis and biological evaluation of potent and selective anaplastic lymphoma kinase (ALK) inhibitors from a novel class of 2,4-diaminopyrimidines, incorporating 2,3,4,5-tetrahydro-benzo[d]azepine fragments, is described. An orally bioavailable analogue (18) that displayed antitumor efficacy in ALCL xenograft models in mice was identified and extensively profiled. Topics: Administration, Oral; Anaplastic Lymphoma Kinase; Animals; Benzazepines; Lymphoma, Large-Cell, Anaplastic; Mice; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Xenograft Model Antitumor Assays	2011

Article

Year

Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models.

Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1

The synthesis and biological evaluation of potent and selective anaplastic lymphoma kinase (ALK) inhibitors from a novel class of 2,4-diaminopyrimidines, incorporating 2,3,4,5-tetrahydro-benzo[d]azepine fragments, is described. An orally bioavailable analogue (18) that displayed antitumor efficacy in ALCL xenograft models in mice was identified and extensively profiled.

Topics: Administration, Oral; Anaplastic Lymphoma Kinase; Animals; Benzazepines; Lymphoma, Large-Cell, Anaplastic; Mice; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Xenograft Model Antitumor Assays

2011