Page last updated: 2024-09-02

tadalafil and Pregnancy

tadalafil has been researched along with Pregnancy in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's15 (53.57)24.3611
2020's13 (46.43)2.80

Authors

AuthorsStudies
Ikeda, T; Kawamura, T; Tachibana, R; Takakura, S; Takeuchi, H; Tanaka, H; Tanaka, K; Yoshikawa, K1
Deprest, J; Kumar, S; Mol, BW; Russo, F; Turner, JM1
Enomoto, N; Ikeda, T; Katsuragi, S; Maki, S; Takakura, S; Tanaka, H; Tanaka, K1
Asghari, A; Hassanpour, S; Imani, MH; Khaksar, E1
Aoki, S; Aoki, Y; Endo, M; Ikeda, T; Kasai, M; Kawamura, H; Kikuchi, N; Kinjo, T; Kotani, T; Kotera, M; Maegawa, Y; Maki, S; Nagao, K; Nakamura, K; Nakata, M; Nii, M; Nishimura, Y; Ogura, T; Sekizawa, A; Suga, S; Takakura, S; Takano, M; Tamaru, S; Tanaka, H; Tanaka, K; Tanaka, Y; Ushida, T; Yasuhi, I; Yasui, O; Yoshida, Y1
Enomoto, N; Hirayama, M; Ikeda, T; Kitamura, A; Kondo, E; Magawa, S; Maki, S; Nii, M; Okamoto, K; Sawada, H; Takakura, S; Tanaka, H; Tanaka, K; Tsuji, M; Yodoya, N1
Baker, PN; Ganzevoort, W; Gluud, C; Groom, KM; Jakobsen, JC; Kariya, CT; Kenny, LC; Leemhuis, AG; Magee, LA; Mol, BWJ; Papageorghiou, AT; Pels, A; Sharp, AN; von Dadelszen, P1
Hashizume, Y; Ikeda, T; Sato, E; Sato, H; Sekimoto, A; Takahashi, N; Tanaka, K1
Endoh, M; Furuhashi, F; Ikeda, T; Kaneda, MK; Kimura, T; Kotani, T; Magawa, S; Maki, S; Nii, M; Nishimura, Y; Ogura, T; Sekizawa, A; Tanaka, H; Tanaka, K; Tsuji, M1
Cai, W; Chen, S; Li, Y; Niu, X; Wang, B; Yang, N1
Enomoto, N; Ikeda, T; Katsuragi, S; Maki, S; Nii, M; Takakura, S; Tanaka, H; Tanaka, K; Toriyabe, K; Tsuchiya, K1
Ikeda, T; Katsuragi, S; Kawamura, T; Maki, S; Tachibana, R; Takeuchi, H; Tanaka, H; Tanaka, K; Toriyabe, K; Yoshikawa, K1
Ikeda, T; Kubo, M; Maki, S; Nii, M; Tanaka, H; Umekawa, T1
Aggarwal, S; Ambalavanan, N; Bradley, WE; Carlisle, MA; Dell'Italia, L; Doran, S; Ford, DA; Jilling, T; Lam, A; Lambert, JA; Matalon, S; Patel, RP; Ren, C1
Ikeda, T; Kamimoto, Y; Kondo, E; Kubo, M; Maki, S; Murabayashi, N; Nii, M; Osato, K; Tanaka, H; Umekawa, T1
Hosoda, H; Ikeda, T; Ikemura, K; Kamimoto, Y; Katayama, K; Kondo, E; Kubo, M; Ma, N; Maki, S; Miyoshi, T; Nii, M; Okuda, M; Osato, K; Tanaka, H; Tanaka, K; Umekawa, T; Yoshida, T; Yoshikawa, K1
Hatano, F; Ikeda, T; Kamimoto, Y; Kubo, M; Magawa, S; Maki, S; Nii, M; Osato, K; Tanaka, H; Tanaka, K; Tsuji, M; Umekawa, T1
Estrada, SM; Ieronimakis, N; Napolitano, PG; Reed, LC; Schmiedecke, SS; Villazana-Kretzer, DL; Walton, RB1
Endoh, M; Ikeda, T; Kamimoto, Y; Kimura, T; Kodera, M; Kotani, T; Kubo, M; Maki, S; Minamide, C; Nakamura, M; Nii, M; Nishikawa, M; Nishimura, Y; Ogura, T; Osato, K; Sekizawa, A; Tamaru, S; Tanaka, H; Tanaka, K; Umekawa, T1
Endoh, M; Furuhashi, F; Hosoda, H; Ikeda, T; Ikemura, K; Kamimoto, Y; Kaneda, MK; Kato, I; Kimura, T; Kondo, E; Ma, N; Magawa, S; Maki, S; Miyoshi, T; Nii, M; Okuda, M; Owa, T; Shimada, K; Tachibana, R; Tanaka, H; Tanaka, K; Tsuji, M; Umekawa, T; Yoshikawa, K1
Artigiane-Neto, R; Fujiki, RTM; Martins, JL; Mismetti, MM; Montero, EFS; Souza, CM; Souza, CVCP; Teixeira, LC1
Furuhashi, F; Ikeda, T; Kondo, E; Kubo, M; Magawa, S; Maki, S; Nii, M; Tanaka, H; Tanaka, K1
Derderian, SC; Etemadi, M; Fineman, JR; Gong, W; Iqbal, C; Johengen, M; Miniati, D; Oishi, P; Schecter, SC; Shue, EH1
Cleary, KL; Običan, SG1
Ikeda, T; Kamimoto, Y; Kubo, M; Murabayashi, N; Nii, M; Osato, K; Sakamoto, M; Tanaka, H; Umekawa, T1
Ikeda, T; Kamimoto, Y; Kubo, M; Maekawa, Y; Murabayashi, N; Nii, M; Osato, K; Tanaka, H; Umekawa, T1
Akdag, E; Akyol, M; Haberal, A; Kayir, H; Kucukozkan, T; Oter, S; Ozdegirmenci, O; Topal, T; Uzbay, T1
Baek, SB; Bahn, G; Kim, BK; Kim, CJ; Kim, KH; Kim, SE; Kim, TS; Ko, IG; Lee, J; Moon, SJ; Shin, MS; Sung, YH1

Reviews

3 review(s) available for tadalafil and Pregnancy

ArticleYear
Phosphodiesterase-5 inhibitors in pregnancy: Systematic review and meta-analysis of maternal and perinatal safety and clinical outcomes.
    BJOG : an international journal of obstetrics and gynaecology, 2022, Volume: 129, Issue:11

    Topics: Cyclic Nucleotide Phosphodiesterases, Type 5; Female; Fetal Distress; Fetal Growth Retardation; Humans; Hypertension, Pulmonary; Infant, Newborn; Phosphodiesterase 5 Inhibitors; Pregnancy; Sildenafil Citrate; Tadalafil

2022
Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy.
    The Cochrane database of systematic reviews, 2023, 07-10, Volume: 7

    Topics: Female; Fetal Death; Fetal Growth Retardation; Humans; Infant, Newborn; Nitric Oxide; Nitroglycerin; Placenta; Pregnancy; Premature Birth; Sildenafil Citrate; Tadalafil

2023
Pulmonary arterial hypertension in pregnancy.
    Seminars in perinatology, 2014, Volume: 38, Issue:5

    Topics: Anesthesia, Obstetrical; Bosentan; Carbolines; Directive Counseling; Epoprostenol; Extracorporeal Membrane Oxygenation; Familial Primary Pulmonary Hypertension; Female; Humans; Iloprost; Infant, Newborn; Piperazines; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Pregnancy, High-Risk; Prognosis; Pulmonary Circulation; Purines; Sildenafil Citrate; Sulfonamides; Tadalafil

2014

Trials

6 trial(s) available for tadalafil and Pregnancy

ArticleYear
Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb).
    BMJ open, 2022, 06-14, Volume: 12, Issue:6

    Topics: Clinical Trials, Phase II as Topic; Double-Blind Method; Female; Fetal Growth Retardation; Fetus; Gestational Age; Humans; Infant, Newborn; Multicenter Studies as Topic; Pregnancy; Randomized Controlled Trials as Topic; Tadalafil; Treatment Outcome

2022
Tadalafil treatment for preeclampsia (medication in preeclampsia; MIE): a multicenter phase II clinical trial.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2021, Volume: 34, Issue:22

    Topics: Female; Fetal Growth Retardation; Humans; Phosphodiesterase 5 Inhibitors; Pre-Eclampsia; Pregnancy; Tadalafil

2021
Safety and dose-finding trial of tadalafil administered for fetal growth restriction: A phase-1 clinical study.
    The journal of obstetrics and gynaecology research, 2017, Volume: 43, Issue:7

    Topics: Adult; Female; Fetal Death; Fetal Growth Retardation; Humans; Phosphodiesterase 5 Inhibitors; Pregnancy; Premature Birth; Tadalafil

2017
Cardiac function and tadalafil used for treating fetal growth restriction in pregnant women without cardiovascular disease.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2019, Volume: 32, Issue:15

    Topics: Adult; Female; Fetal Growth Retardation; Heart; Humans; Pregnancy; Tadalafil; Vasodilator Agents

2019
TADAFER II: Tadalafil treatment for fetal growth restriction - a study protocol for a multicenter randomised controlled phase II trial.
    BMJ open, 2018, 10-30, Volume: 8, Issue:10

    Topics: Clinical Trials, Phase II as Topic; Female; Fetal Growth Retardation; Gestational Age; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Japan; Multicenter Studies as Topic; Perinatal Mortality; Phosphodiesterase 5 Inhibitors; Pregnancy; Prenatal Care; Prospective Studies; Randomized Controlled Trials as Topic; Tadalafil; Ultrasonography, Doppler

2018
Phase-1 clinical study of tadalafil administered for selective fetal growth restriction in twin pregnancy.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2021, Volume: 34, Issue:7

    Topics: Female; Fetal Growth Retardation; Humans; Infant, Newborn; Placenta; Pregnancy; Pregnancy, Twin; Tadalafil; Twins, Monozygotic

2021

Other Studies

19 other study(ies) available for tadalafil and Pregnancy

ArticleYear
Tadalafil Treatment of Mice with Fetal Growth Restriction and Preeclampsia Improves Placental mTOR Signaling.
    International journal of molecular sciences, 2022, Jan-27, Volume: 23, Issue:3

    Topics: Animals; Female; Fetal Growth Retardation; Mice; NG-Nitroarginine Methyl Ester; Placenta; Pre-Eclampsia; Pregnancy; Signal Transduction; Tadalafil; TOR Serine-Threonine Kinases

2022
Maternal blood concentration of tadalafil in pregnancy: Comparison of pregnant and non-pregnant women.
    Taiwanese journal of obstetrics & gynecology, 2022, Volume: 61, Issue:2

    Topics: Female; Fetal Growth Retardation; Humans; Placental Circulation; Pregnancy; Pregnant Women; Tadalafil

2022
Parental exposure of Tadalafil has beneficial effect on reflexive motor behaviors in mice offspring.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2022, Volume: 82, Issue:5

    Topics: Animals; Antidepressive Agents; Antioxidants; Female; Glutathione Peroxidase; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Superoxide Dismutase; Tadalafil

2022
Fetal Biometric Assessment and Infant Developmental Prognosis of the Tadalafil Treatment for Fetal Growth Restriction.
    Medicina (Kaunas, Lithuania), 2023, May-08, Volume: 59, Issue:5

    Topics: Biometry; Child; Female; Fetal Growth Retardation; Humans; Infant; Infant, Newborn; Pregnancy; Prognosis; Retrospective Studies; Tadalafil; Ultrasonography, Prenatal

2023
Tadalafil alleviates preeclampsia and fetal growth restriction in RUPP model of preeclampsia in mice.
    Biochemical and biophysical research communications, 2020, 01-15, Volume: 521, Issue:3

    Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Fetal Growth Retardation; Hypertension; Male; Mice; Phosphodiesterase 5 Inhibitors; Pre-Eclampsia; Pregnancy; Tadalafil

2020
Effect and mechanism of prophylactic use of tadalafil during pregnancy on l-NAME-induced preeclampsia-like rats.
    Placenta, 2020, 09-15, Volume: 99

    Topics: Animals; Blood Pressure; Cytokines; Female; Femoral Artery; Kidney; NG-Nitroarginine Methyl Ester; Phosphodiesterase 5 Inhibitors; Placenta; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; Tadalafil; Ultrasonography

2020
Tadalafil Treatment Ameliorates Hypoxia and Alters Placental Expression of Proteins Downstream of mTOR Signaling in Fetal Growth Restriction.
    Medicina (Kaunas, Lithuania), 2020, Dec-21, Volume: 56, Issue:12

    Topics: Female; Fetal Growth Retardation; Humans; Hypoxia; Pregnancy; Sirolimus; Tadalafil; TOR Serine-Threonine Kinases

2020
Maternal tadalafil therapy for fetal growth restriction prevents non-alcoholic fatty liver disease and adipocyte hypertrophy in the offspring.
    Scientific reports, 2021, 01-13, Volume: 11, Issue:1

    Topics: Adipocytes; Animals; Diet, High-Fat; Female; Fetal Development; Fetal Growth Retardation; Glucose Tolerance Test; Hypertension; Hypertrophy; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Non-alcoholic Fatty Liver Disease; Pregnancy; Prenatal Exposure Delayed Effects; Tadalafil

2021
Treatment using tadalafil for severe pre-eclampsia with fetal growth restriction.
    The journal of obstetrics and gynaecology research, 2017, Volume: 43, Issue:7

    Topics: Adult; Female; Fetal Growth Retardation; Humans; Phosphodiesterase 5 Inhibitors; Pre-Eclampsia; Pregnancy; Tadalafil

2017
Mechanisms and Treatment of Halogen Inhalation-Induced Pulmonary and Systemic Injuries in Pregnant Mice.
    Hypertension (Dallas, Tex. : 1979), 2017, Volume: 70, Issue:2

    Topics: Animals; Bromine; Disease Models, Animal; Female; Fetal Growth Retardation; Hypertension; Inhalation Exposure; Lung Injury; Mice; Oxidants; Phosphodiesterase 5 Inhibitors; Placenta; Pre-Eclampsia; Pregnancy; Systemic Inflammatory Response Syndrome; Tadalafil; Treatment Outcome

2017
Tadalafil Improves L-NG-Nitroarginine Methyl Ester-Induced Preeclampsia With Fetal Growth Restriction-Like Symptoms in Pregnant Mice.
    American journal of hypertension, 2017, Dec-08, Volume: 31, Issue:1

    Topics: Animals; Blood Pressure; Cyclic GMP; Enzyme Inhibitors; Female; Fetal Development; Fetal Growth Retardation; Kidney; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Oxidative Stress; Phosphodiesterase 5 Inhibitors; Placenta; Pre-Eclampsia; Pregnancy; Proteinuria; Tadalafil

2017
Evaluation of Sildenafil and Tadalafil for Reversing Constriction of Fetal Arteries in a Human Placenta Perfusion Model.
    Hypertension (Dallas, Tex. : 1979), 2018, Volume: 72, Issue:1

    Topics: Arteries; Female; Fetal Growth Retardation; Humans; Perfusion; Phosphodiesterase 5 Inhibitors; Placenta; Pregnancy; Sildenafil Citrate; Tadalafil; Vasoconstriction

2018
Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions.
    Scientific reports, 2019, 01-18, Volume: 9, Issue:1

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Disease Models, Animal; Female; Fetal Growth Retardation; Hypoxia; Mice; Placenta; Pre-Eclampsia; Pregnancy; Tadalafil; Treatment Outcome; Vasodilator Agents

2019
Oxidative stress assessment in intestine of newborn rats submitted to hypoxia and reoxygenation with tadalafil.
    Acta cirurgica brasileira, 2019, Apr-29, Volume: 34, Issue:4

    Topics: Animals; Animals, Newborn; Female; Humans; Hypoxia; Intestinal Mucosa; Lipid Peroxidation; Malondialdehyde; Nitrates; Nitrites; Oxidative Stress; Oxygen; Phosphodiesterase 5 Inhibitors; Pregnancy; Random Allocation; Rats, Wistar; Reproducibility of Results; Tadalafil; Time Factors

2019
Antenatal maternally-administered phosphodiesterase type 5 inhibitors normalize eNOS expression in the fetal lamb model of congenital diaphragmatic hernia.
    Journal of pediatric surgery, 2014, Volume: 49, Issue:1

    Topics: Animals; Carbolines; Cyclic GMP; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Induction; Female; Fetal Diseases; Fetal Therapies; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Maternal-Fetal Exchange; Nitric Oxide Synthase Type III; Organ Size; Phosphodiesterase 5 Inhibitors; Pregnancy; Random Allocation; Second Messenger Systems; Sheep; Tadalafil

2014
Early-onset fetal growth restriction treated with the long-acting phosphodiesterase-5 inhibitor tadalafil: a case report.
    Journal of medical case reports, 2016, Nov-08, Volume: 10, Issue:1

    Topics: Adult; Asian People; Cesarean Section; Female; Fetal Growth Retardation; Gestational Age; Humans; Infant, Newborn; Male; Oligohydramnios; Phosphodiesterase 5 Inhibitors; Pregnancy; Pregnancy Outcome; Tadalafil; Ultrasonography, Prenatal

2016
Retrospective study of tadalafil for fetal growth restriction: Impact on maternal and perinatal outcomes.
    The journal of obstetrics and gynaecology research, 2017, Volume: 43, Issue:2

    Topics: Adult; Birth Weight; Delivery, Obstetric; Female; Fetal Growth Retardation; Humans; Outcome Assessment, Health Care; Phosphodiesterase 5 Inhibitors; Pregnancy; Retrospective Studies; Tadalafil

2017
Effects of sildenafil and tadalafil on ischemia/reperfusion injury in fetal rat brain.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2011, Volume: 24, Issue:2

    Topics: Animals; Brain; Carbolines; Female; Fetus; Glutathione Peroxidase; Malondialdehyde; Piperazines; Pregnancy; Purines; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Sildenafil Citrate; Sulfones; Superoxide Dismutase; Tadalafil; Vasodilator Agents

2011
The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups.
    Neuroscience letters, 2011, Jan-13, Volume: 488, Issue:1

    Topics: Age Factors; Animals; Animals, Newborn; Apoptosis; Avoidance Learning; Bromodeoxyuridine; Carbolines; Caspase 3; Cell Proliferation; Dentate Gyrus; Depression; Disease Models, Animal; DNA Fragmentation; Female; Freezing Reaction, Cataleptic; In Situ Nick-End Labeling; Maternal Deprivation; Memory Disorders; Phosphodiesterase 5 Inhibitors; Pregnancy; Rats; Rats, Sprague-Dawley; Reaction Time; Swimming; Tadalafil

2011