tacrolimus and Vulvar-Neoplasms

Transplant recipients have elevated cancer risk including risk of human papillomavirus (HPV)-associated cancers of the cervix, anus, penis, vagina, vulva and oropharynx. We examined the incidence of HPV-related cancers in 187 649 US recipients in the Transplant Cancer Match Study. Standardized incidence ratios (SIRs) compared incidence rates to the general population, and incidence rate ratios (IRRs) compared rates across transplant subgroups. We observed elevated incidence of HPV-related cancers (SIRs: in situ 3.3-20.3, invasive 2.2-7.3), except for invasive cervical cancer (SIR 1.0). Incidence increased with time since transplant for vulvar, anal and penile cancers (IRRs 2.1-4.6 for 5+ vs. <2 years). Immunophenotype, characterized by decreased incidence with HLA DRB1:13 and increased incidence with B:44, contributed to susceptibility at several sites. Use of specific immunosuppressive medications was variably associated with incidence; for example, tacrolimus, was associated with reduced incidence for some anogenital cancers (IRRs 0.4-0.7) but increased incidence of oropharyngeal cancer (IRR 2.1). Thus, specific features associated with recipient characteristics, transplanted organs and medications are associated with incidence of HPV-related cancers after transplant. The absence of increased incidence of invasive cervical cancer highlights the success of cervical screening in this population and suggests a need for screening for other HPV-related cancers.

Topics: Adolescent; Adult; Anus Neoplasms; Cohort Studies; Female; Humans; Immunosuppression Therapy; Incidence; Male; Middle Aged; Organ Transplantation; Oropharyngeal Neoplasms; Papillomavirus Infections; Penile Neoplasms; Registries; Tacrolimus; United States; Uterine Cervical Neoplasms; Vulvar Neoplasms; Young Adult

Hailey-Hailey disease (HHD) is a rare, autosomal dominant intraepidermal blistering disorder characterized by recurrent vesicles and erosions affecting mostly the intertriginous areas. We report a case of HHD affecting exclusively the vulva from which an invasive squamous cell carcinoma developed after tacrolimus therapy.

Topics: Adult; Carcinoma, Squamous Cell; Female; Humans; Immunosuppressive Agents; Lymph Node Excision; Pemphigus, Benign Familial; Tacrolimus; Vulvar Diseases; Vulvar Neoplasms

Squamous cell carcinoma (SCC) has a recognized association with lichen sclerosus (LS) of the vulva. Several recent reports have indicated the usefulness of the new macrolide immunosuppressant agents pimecrolimus and tacrolimus in the treatment of LS, emphasizing the advantage over topical corticosteroids of lack of atophogenicity. Despite this there may be risks involved that could outweigh this benefit. The potential of these medications to potentiate the risk of SCC in LS in the short and long-term is unknown. Once lichen sclerosus is well controlled, there is often no need for ongoing use of superpotent corticosteroids, and there may be no reason to use immunosuppressants when moderate-strength corticosteroids provide adequate control.. A 73-year-old woman with a 10-year history of hypertrophic LS and genital psoriasis presented with intractable superimposed inflammatory vulvitis. She was treated with topical pimecrolimus 1% cream on the assumption that she was either allergic to or intolerant of topical corticosteroids. One month after commencing therapy, she suddenly developed a rapidly growing vulvar tumor. This was excised and proved to be a well-differentiated squamous cell carcinoma.. It may be safest to restrict the use of topical immunosuppressives to patients with LS who are unable to use topical corticosteroids because of the risk of potentiating SCC.

Topics: Administration, Topical; Aged; Carcinoma, Squamous Cell; Female; Humans; Immunosuppressive Agents; Risk Factors; Tacrolimus; Vulvar Lichen Sclerosus; Vulvar Neoplasms