tacrolimus and Soft-Tissue-Infections

Skin and soft tissue infection (SSTI) is the most common of infectious diseases with high morbidity and mortality. However, the clinical characteristics of SSTI in patients with nephrotic syndrome (NS), especially in those patients who received immunosuppressive therapy, are still lacking. The present study was conducted to investigate the clinical characteristics and outcomes of SSTI in patients with NS.. A retrospective study was carried out among the patients diagnosed with NS and SSTI, who have priorly received or currently have been receiving immunosuppressive therapy between April 2011 and January 2019; the clinical profile included patient's baseline characteristics, clinical presentation, microbiological findings, treatment, and prognosis.. A total of 70 patients were analyzed. Results showed that more than half of the patients were under 35 years old, and moderate infection was the most common type of SSTI. Leg and cellulitis were the most common site of lesion and the typical clinical manifestation of SSTI, respectively. Patients in the severe infection group have a higher level of procalcitonin (PCT) and C-reactive protein (CRP), while a lower level of albumin, CD4. Patients with NS and SSTI usually showed a satisfying outcome with proper anti-infection treatment, but severe SSTI can be life-threatening.

Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; C-Reactive Protein; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Cellulitis; Child; Cyclophosphamide; Female; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Leg; Male; Middle Aged; Nephrotic Syndrome; Prednisone; Procalcitonin; Retrospective Studies; Serum Albumin; Severity of Illness Index; Soft Tissue Infections; Tacrolimus; Young Adult

Soft-tissue masses are rarely associated with Histoplasma capsulatum infection. We describe a heart transplant patient who presented with a large right-sided chest wall mass as a manifestation of disseminated histoplasmosis. A successful clinical outcome was achieved upon recognition of the fungal pathogen.

Topics: Aged; Amphotericin B; Antifungal Agents; Biopsy; Debridement; Diagnosis, Differential; Drug Administration Schedule; Drug Therapy, Combination; Graft Rejection; Heart Transplantation; Histoplasma; Histoplasmosis; Humans; Immunosuppressive Agents; Itraconazole; Male; Mycophenolic Acid; Soft Tissue Infections; Tacrolimus; Thoracic Wall; Tomography, X-Ray Computed; Transplantation Conditioning