tacrolimus and Retroperitoneal-Fibrosis

Multifocal fibrosclerosis is the term used to represent a combination of similar fibrous lesions occurring at different anatomical sites. We herein report a hypertrophic pachymeningitis patient with a soft tissue mass around the thoracic vertebral bodies. A histopathological analysis of the biopsied tissues from both lesions showed dense fibrosis and a marked infiltration of lymphocytes and plasma cells, which lead to the diagnosis of multifocal fibrosclerosis. This pathological condition closely resembles that of IgG4-related disease and is a very rare combination of manifestations. Our case suggests that hypertrophic pachymeningitis patients need to also undergo a whole body examination.

Topics: Aged; Anti-Inflammatory Agents; Humans; Hypertrophy; Immunosuppressive Agents; Male; Meningitis; Methylprednisolone; Plasma Cells; Retroperitoneal Fibrosis; Tacrolimus; Thoracic Vertebrae; Treatment Outcome