tacrolimus and Pruritus-Ani

Pruritus ani (PA) is defined as intense chronic itching affecting perianal skin.. We aimed to determine the efficacy of topical tacrolimus treatment in atopic dermatitis (AD) patients who have PA.. The study included 32 patients with AD who were suffering PA. Patients were randomized into two groups. In total, 16 patients used 0.03% tacrolimus ointment and 16 patients used vaseline as placebo. All groups applied topical treatments to their perianal area twice daily for 4 weeks. The treatments were then reversed for 4 weeks after a 2 weeks wash out period.. In total, 32 patients with AD who had refractory anal itching were enrolled in this study. None of the patients had obtained successful results with previous treatments. There was a statistically significant decrease in the recorded EASI, DLQI and itching scores for the tacrolimus group compared to the placebo group at weeks 4 and 6 of treatment (p < 0.05).. Topical tacrolimus treatment was well tolerated and effective in controlling persistent PA in AD patients.

Topics: Administration, Topical; Adolescent; Adult; Antipruritics; Dermatitis, Atopic; Emollients; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; Petrolatum; Pruritus Ani; Tacrolimus; Young Adult

Topics: Administration, Topical; Adult; Cross-Over Studies; Female; Humans; Male; Middle Aged; Placebos; Pruritus Ani; Tacrolimus

To unearth the clinical efficacy of tacrolimus ointment + 3% boric acid lotion joint Chinese angelica decoction in chronic perianal eczema.. Patients with chronic perianal eczema admitted to hospital from June 2018 and June 2019 were retrospectively analyzed. Patients in the control group (. No significant differences were found in the baseline information between the observation group and control group before therapy. After therapy, pruritus ani score (. With respect to tacrolimus ointment + 3% boric acid lotion, patients with chronic perianal eczema displayed better clinical efficacy after jointly being treated by Chinese angelica decoction.

Topics: Adult; Angelica; Animals; Anus Diseases; Boric Acids; Case-Control Studies; Chronic Disease; Computational Biology; Drug Therapy, Combination; Drugs, Chinese Herbal; Eczema; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; Ointments; Phytotherapy; Pruritus Ani; Retrospective Studies; Skin Cream; Tacrolimus; Treatment Outcome