tacrolimus and Penile-Diseases

Topics: Administration, Cutaneous; Anti-Infective Agents, Local; Child; Drug Therapy, Combination; Ethacridine; Humans; Immunosuppressive Agents; Male; Penile Diseases; Skin Diseases; Tacrolimus

Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Humans; Lichen Planus; Male; Middle Aged; Penile Diseases; Tacrolimus; Treatment Outcome

Topics: Administration, Cutaneous; Crohn Disease; Granuloma; Humans; Immunosuppressive Agents; Male; Penile Diseases; Recurrence; Skin Diseases; Tacrolimus; Young Adult

Topics: Administration, Cutaneous; Dermatologic Agents; Humans; Lichen Nitidus; Male; Penile Diseases; Tacrolimus; Young Adult

Topics: Humans; Immunosuppressive Agents; Male; Middle Aged; Ointments; Penile Diseases; Pyoderma Gangrenosum; Tacrolimus

Crohn's disease is a chronic granulomatous inflammatory bowel disorder, often associated with cutaneous manifestations, termed metastatic Crohn's. Here we present two cases of paediatric metastatic Crohn's disease involving the penis, focusing on clinical presentation, histological diagnosis and treatment.

Topics: Anti-Infective Agents; Child; Child, Preschool; Circumcision, Male; Crohn Disease; Diagnosis, Differential; Drug Therapy, Combination; Follow-Up Studies; Foreskin; Humans; Immunosuppressive Agents; Male; Metronidazole; Ointments; Penile Diseases; Tacrolimus

Topics: Aged; Condylomata Acuminata; Female; Human papillomavirus 11; Humans; Immunosuppressive Agents; Lichen Sclerosus et Atrophicus; Male; Middle Aged; Penile Diseases; Tacrolimus; Virus Activation; Vulvar Diseases; Vulvar Lichen Sclerosus

Topics: Administration, Topical; Humans; Immunosuppressive Agents; Lichen Planus; Lichen Planus, Oral; Male; Middle Aged; Penile Diseases; Tacrolimus; Thalidomide

Topics: Administration, Topical; Aged; Humans; Immunosuppressive Agents; Male; Penile Diseases; Pyoderma Gangrenosum; Tacrolimus

Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Child; Diagnosis, Differential; Humans; Male; Penile Diseases; Psoriasis; Tacrolimus

Lichen sclerosus of the anogenital area is a chronic inflammatory and fibrosclerotic disease associated with substantial morbidity. Topical ultrapotent corticosteroids are currently the treatment of choice.. Three prepubertal girls and 3 adults (2 men, 1 woman) were treated with 0.1% tacrolimus ointment once daily. All patients experienced complete resolution with long-lasting remission for up to 1 year. No major adverse effects were observed, and treatment was well tolerated.. Topical tacrolimus is a promising novel agent in the treatment of lichen sclerosus of the anogenital area. A major advantage over topical corticosteroids is the lack of skin atrophy. Further clinical trials are warranted to confirm our findings.

Topics: Administration, Topical; Adult; Anus Diseases; Child; Child, Preschool; Female; Humans; Immunosuppressive Agents; Lichen Sclerosus et Atrophicus; Male; Middle Aged; Ointments; Penile Diseases; Tacrolimus; Vulvar Diseases