tacrolimus and Nail-Diseases

Nail involvement in lichen striatus (LS) is rare and has not been documented extensively.. This study describes the clinical and histological features, response to treatment, and follow-up in seven patients with nail LS.. We reviewed seven cases of nail LS between 2006 and 2012 at the Dermatology Department, Yeouido St Mary's Hospital, Seoul, South Korea.. The median patient age was 11 years (range: 4-33 years), and the female:male ratio was 3:4. All patients had both typical skin lesions and nail abnormalities. In these cases, LS usually involved a single digit (n = 5). The most common nail change was longitudinal fissuring (n = 4). We actively treated both skin and nail lesions from the time of diagnosis. Most nail lesions resolved within a mean of four months of the initiation of treatment.. Nail involvement in LS is rare; this case series highlights the associated nail changes. We emphasize that early accurate diagnosis and treatment may be beneficial in reducing nail deformities in patients with nail involvement.

Topics: Adrenal Cortex Hormones; Adult; Child; Child, Preschool; Drug Therapy, Combination; Female; Foot Dermatoses; Hand Dermatoses; Humans; Immunosuppressive Agents; Lichenoid Eruptions; Male; Nail Diseases; Tacrolimus; Triamcinolone Acetonide

Despite recent advances in the treatment of psoriasis, the therapeutic options for nail psoriasis are very limited, particularly when this is the only manifestation of the disease.. We performed a randomized controlled open-label study to assess the efficacy and safety of a topical treatment with tacrolimus 0.1% ointment in nail psoriasis.. In each patient, tacrolimus 0.1% ointment was prescribed for application only on the affected nails of a randomly selected hand for 12 weeks, whereas nails of the other hand did not receive any treatment. Severity of nail psoriasis was evaluated using the Nail Psoriasis Severity Index (NAPSI) score.. We enrolled 21 consecutive psoriatic patients. At week 12, a statistically significant (P < 0.001) improvement was obtained in the treated hands with respect to the hands used as control (NAPSI score absolute change 13.0 and 3.0 respectively). Each of the enrolled patients concluded the period of treatment, but one patient was withdrawn from tacrolimus application after 9 weeks because of the appearance of acute paronychia.. Our study showed that tacrolimus 0.1% ointment may be an efficacious and safe therapeutic opportunity in the treatment of nail psoriasis. Our data should be confirmed by a double-blind study with a larger sample of patients.

Topics: Humans; Immunosuppressive Agents; Nail Diseases; Ointments; Psoriasis; Tacrolimus

Topics: Alopecia; Erythema; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Male; Nail Diseases; Tacrolimus; Wiskott-Aldrich Syndrome

Topics: Administration, Topical; Adolescent; Adult; Child; Female; Humans; Immunosuppressive Agents; Lichen Planus; Male; Middle Aged; Nail Diseases; Tacrolimus; Treatment Outcome; Young Adult

Topics: Humans; Immunosuppressive Agents; Male; Nail Diseases; Ointments; Tacrolimus; Young Adult

Topics: Cyclosporine; Female; Humans; Middle Aged; Muscle Weakness; Myositis; Nail Diseases; Pyoderma Gangrenosum; Tacrolimus; Toes; Treatment Outcome

Topics: Adult; Eczema; Humans; Immunosuppressive Agents; Male; Nail Diseases; Ointments; Tacrolimus