tacrolimus and Myopathies--Nemaline

tacrolimus has been researched along with Myopathies--Nemaline* in 1 studies

Other Studies

1 other study(ies) available for tacrolimus and Myopathies--Nemaline

Article	Year
[A case of sporadic late-onset nemaline myopathy associated with myasthenia gravis positive for anti-titin antibody and anti-Kv1.4 antibody]. Rinsho shinkeigaku = Clinical neurology, 2020, Jul-31, Volume: 60, Issue:7 A 66-year-old woman who had myasthenia gravis (MG) admitted for type II respiratory failure and right heart failure. Although she had neither ptosis, eye movement disorder, nor diplopia, she had orbital muscles weakness, reduction of gag reflex, dysarthria, dysphagia, and mild proximal muscle weakness. Blood tests showed anti-striated muscle antibodies (anti-titin antibody and anti-Kv1.4 antibody). A muscle biopsy of the left biceps showed a marked variation in fiber size, mild mononuclear cell infiltration was seen surrounding blood vessels in perimysium and nemaline bodies in some fibers. Immunohistochemical stains showed many muscle fibers express HLA-ABC. The patient was diagnosed as sporadic late-onset nemaline myopathy (SLONM) with MG, and treated by tacrolimus. After treatment, her respiratory function gradually improved and she discharged. In the case of atypical MG, measurement of anti-striated muscle antibody or muscle biopsy should be considered. Topics: Aged; Animals; Autoantibodies; Biomarkers; Connectin; Female; HLA Antigens; Humans; Kv1.4 Potassium Channel; Myasthenia Gravis; Myopathies, Nemaline; Tacrolimus; Treatment Outcome	2020

Article

Year

[A case of sporadic late-onset nemaline myopathy associated with myasthenia gravis positive for anti-titin antibody and anti-Kv1.4 antibody].

Rinsho shinkeigaku = Clinical neurology, 2020, Jul-31, Volume: 60, Issue:7

A 66-year-old woman who had myasthenia gravis (MG) admitted for type II respiratory failure and right heart failure. Although she had neither ptosis, eye movement disorder, nor diplopia, she had orbital muscles weakness, reduction of gag reflex, dysarthria, dysphagia, and mild proximal muscle weakness. Blood tests showed anti-striated muscle antibodies (anti-titin antibody and anti-Kv1.4 antibody). A muscle biopsy of the left biceps showed a marked variation in fiber size, mild mononuclear cell infiltration was seen surrounding blood vessels in perimysium and nemaline bodies in some fibers. Immunohistochemical stains showed many muscle fibers express HLA-ABC. The patient was diagnosed as sporadic late-onset nemaline myopathy (SLONM) with MG, and treated by tacrolimus. After treatment, her respiratory function gradually improved and she discharged. In the case of atypical MG, measurement of anti-striated muscle antibody or muscle biopsy should be considered.

Topics: Aged; Animals; Autoantibodies; Biomarkers; Connectin; Female; HLA Antigens; Humans; Kv1.4 Potassium Channel; Myasthenia Gravis; Myopathies, Nemaline; Tacrolimus; Treatment Outcome

2020