tacrolimus and Monkey-Diseases

tacrolimus has been researched along with Monkey-Diseases* in 2 studies

Other Studies

2 other study(ies) available for tacrolimus and Monkey-Diseases

Article	Year
Tacrolimus ointment: a novel and effective topical treatment of localized atopic dermatitis in a rhesus macaque (Macaca mulatta). Journal of the American Association for Laboratory Animal Science : JAALAS, 2009, Volume: 48, Issue:3 An adult, male, rhesus macaque presented with pruritus and a focal, exudative, inflamed, erythematous skin lesion of approximately 2 cm in diameter on the ventral aspect of the mandible. The lesion resolved after 10 d of treatment with 1% chlorhexidine solution and triple-antibiotic ointment. However, the skin lesion subsequently recurred several times over a 2-mo period. A punch biopsy was performed, and histological changes were most consistent with a diagnosis of atopic dermatitis. Treatment with topical tacrolimus ointment, an immunosuppressive drug, proved successful in the resolution of all clinical signs after 4 mo. According to a literature review, this article is the first report of the use of tacrolimus ointment as a topical treatment of atopic dermatitis in a rhesus macaque. Topics: Animals; Dermatitis, Atopic; Immunosuppressive Agents; Macaca mulatta; Male; Monkey Diseases; Ointments; Tacrolimus; Treatment Outcome	2009
Comparison of tamarins and marmosets as hosts for GBV-B infections and the effect of immunosuppression on duration of viremia. Virology, 2003, Jun-20, Volume: 311, Issue:1 GBV-B virus is a close relative to hepatitis C virus (HCV) that causes hepatitis in tamarins, and thus, is an attractive surrogate model for HCV. In this study, we demonstrate that the host range of GBV-B extends to the common marmoset with an infection profile similar to that observed for tamarins. Marmoset hepatocytes were susceptible to in vitro infection with GBV-B. Virus was efficiently secreted into the medium, and approximately 25% of hepatocytes were positive for NS3 staining. In an attempt to induce persistent infections, tamarins were immunosuppressed with FK506 and inoculated with GBV-B. Although no chronic infections were induced, the duration of viremia was increased in most animals. In one animal, the duration of viremia was extended to 46 weeks, but viral clearance occurred 18 weeks after stopping FK506 therapy. The greater availability of marmosets in comparison to tamarins will greatly facilitate future research efforts with this model. Topics: Animals; Callithrix; Cells, Cultured; Disease Models, Animal; Flaviviridae Infections; GB virus B; Hepatitis, Viral, Animal; Hepatocytes; Immunocompromised Host; Immunosuppressive Agents; Monkey Diseases; Saguinus; Tacrolimus; Time Factors; Viremia	2003

Article

Year

Tacrolimus ointment: a novel and effective topical treatment of localized atopic dermatitis in a rhesus macaque (Macaca mulatta).

Journal of the American Association for Laboratory Animal Science : JAALAS, 2009, Volume: 48, Issue:3

An adult, male, rhesus macaque presented with pruritus and a focal, exudative, inflamed, erythematous skin lesion of approximately 2 cm in diameter on the ventral aspect of the mandible. The lesion resolved after 10 d of treatment with 1% chlorhexidine solution and triple-antibiotic ointment. However, the skin lesion subsequently recurred several times over a 2-mo period. A punch biopsy was performed, and histological changes were most consistent with a diagnosis of atopic dermatitis. Treatment with topical tacrolimus ointment, an immunosuppressive drug, proved successful in the resolution of all clinical signs after 4 mo. According to a literature review, this article is the first report of the use of tacrolimus ointment as a topical treatment of atopic dermatitis in a rhesus macaque.

Topics: Animals; Dermatitis, Atopic; Immunosuppressive Agents; Macaca mulatta; Male; Monkey Diseases; Ointments; Tacrolimus; Treatment Outcome

2009

Comparison of tamarins and marmosets as hosts for GBV-B infections and the effect of immunosuppression on duration of viremia.

Virology, 2003, Jun-20, Volume: 311, Issue:1

GBV-B virus is a close relative to hepatitis C virus (HCV) that causes hepatitis in tamarins, and thus, is an attractive surrogate model for HCV. In this study, we demonstrate that the host range of GBV-B extends to the common marmoset with an infection profile similar to that observed for tamarins. Marmoset hepatocytes were susceptible to in vitro infection with GBV-B. Virus was efficiently secreted into the medium, and approximately 25% of hepatocytes were positive for NS3 staining. In an attempt to induce persistent infections, tamarins were immunosuppressed with FK506 and inoculated with GBV-B. Although no chronic infections were induced, the duration of viremia was increased in most animals. In one animal, the duration of viremia was extended to 46 weeks, but viral clearance occurred 18 weeks after stopping FK506 therapy. The greater availability of marmosets in comparison to tamarins will greatly facilitate future research efforts with this model.

Topics: Animals; Callithrix; Cells, Cultured; Disease Models, Animal; Flaviviridae Infections; GB virus B; Hepatitis, Viral, Animal; Hepatocytes; Immunocompromised Host; Immunosuppressive Agents; Monkey Diseases; Saguinus; Tacrolimus; Time Factors; Viremia

2003