tacrolimus and Lip-Diseases

Topics: Adult; Anti-Bacterial Agents; Dermatitis, Allergic Contact; Dermatologic Agents; Facial Dermatoses; Female; Humans; Lip Diseases; Mupirocin; Patch Tests; Tacrolimus

Topics: Child, Preschool; Cyclosporine; Drug Substitution; Humans; Hypertrophy; Immunosuppressive Agents; Lip; Lip Diseases; Male; Nephrotic Syndrome; Remission Induction; Tacrolimus; Treatment Outcome

Topical calcineurin inhibitors are widely used to treat inflammatory dermatoses for their steroid-sparing advantage. Herein, we report a patient with chronic lip dermatitis who developed multiple labial melanotic macules after application of tacrolimus 0.1% ointment and pimecrolimus 1% cream. Prior and current reports raise concerns for potential development of pigmented lesions associated with topical calcineurin inhibitor use. These reports highlight the need for careful risk-benefit assessment when prescribing topical calcineurin inhibitors for inflammatory dermatoses, especially when used on sun-exposed sites.

Topics: Administration, Cutaneous; Adult; Biopsy; Calcineurin Inhibitors; Dermatitis, Atopic; Diagnosis, Differential; Female; Humans; Lentigo; Lip Diseases; Peptidylprolyl Isomerase; Tacrolimus

Annular atrophic lichen planus is a rare form of lichen planus, clinically characterized by a circumscribed annular configuration. We report herein a 32-year-old female who developed depressed plaques on the lips. Physical examination showed well-circumscribed, erythematous plaques on the lower lip. The border was slightly elevated and the inner portion was depressed and atrophic. Also, a bean-sized well-circumscribed plaque with slightly elevated border was found on the upper lip. A biopsy specimen revealed that the epithelium of the mucous membrane was reduced in thickness and a mononuclear cell infiltration invaded the basement membrane of the epithelium. This is the first case of annular atrophic lichen planus involving the lip. She was treated with 0.1 percent tacrolimus ointment once daily, which resulted in a beneficial effect.

Topics: Adult; CD8-Positive T-Lymphocytes; Female; Humans; Immunosuppressive Agents; Lichen Planus, Oral; Lip Diseases; Ointments; Patch Tests; Tacrolimus; Treatment Outcome; Zinc

Lichen planus (LP), the prototype of lichenoid dermatoses, is an idiopathic inflammatory disease of the skin and mucous membranes, hair follicles, and nails. It rarely occurs on the lips and usually then in association with oral lesions. We report a 40-year-old man with a 3-month history of an isolated single annular violaceous plaque of the lower lip. The rest of his mucosae, skin, hair and nails were normal. Histopathology confirmed the diagnosis of LP. The patient was advised to use topical tacrolimus 0.03 percent cream twice daily along with multivitamins, but the patient was lost to follow-up. Isolated LP of the lip is unusual, although this condition may be underestimated and therefore under-reported in the literature.

Topics: Adult; Humans; Immunosuppressive Agents; Lichen Planus, Oral; Lip Diseases; Lost to Follow-Up; Male; Ointments; Tacrolimus

Topics: Administration, Topical; Adolescent; Adult; Dermatitis, Atopic; Dermoscopy; Female; Humans; Immunosuppressive Agents; Lip Diseases; Male; Melanosis; Tacrolimus