tacrolimus and Hyperthyroidism

Localized or pretibial myxedema is one of the signs of Graves disease (along with goiter, exophthalmus, thyroid acropathy, and high circulating levels of long-acting thyroid-stimulating hormone) and usually tends to occur at a later stage of the disease or even after the patient becomes euthyroid post treatment. Very rarely has it been reported in euthyroid patients. We report a euthyroid man presenting with localized myxedema on the extensor surface of his forearm with clinical and histopathological features consistent with pretibial myxedema. He responded partially to topical clobetasol propionate cream and tacrolimus ointment 0.1 percent for about 7 months. To the best of our knowledge, this is the first case of preradial myxedema in a euthyroid patient in the English international dermatological literature.

Topics: Aged; Anti-Inflammatory Agents; Biopsy; Clobetasol; Diagnostic Errors; Forearm; Humans; Hyperthyroidism; Immunosuppressive Agents; Leprosy; Male; Mucins; Myxedema; Skin; Tacrolimus; Thyroid Hormones