tacrolimus and Helicobacter-Infections

Renal transplantation is the definitive treatment for end stage renal disease. Patients subjected to transplantation require lifelong immunosuppression and are prone to several gastrointestinal disorders. Dyspepsia is a common disorder in these patients. The objective of this study was to determine factors leading to dyspepsia in renal (kidney) transplant recipients.. It was a cross sectional study conducted at department of hepatogastroenterology and transplant sciences, SIUT Karachi, from 1-6-15 to 1-12-15 for six months. All renal transplanted patients having dyspeptic symptoms for more than 6 weeks. EGD was performed, biopsy specimens obtained from antrum and duodenum, these were sent for histopathological examination. Frequency and percentages were obtained for categorical variables, mean ± SD was calculated for continuous variables. Chi square test was used for categorical variable and student t-test for continuous variables.. Ninety patients were included in the study out of which 64 (71.1%) were males, mean age was 35.82 ± 10.04 years (range: 18-65 years). Gastritis (non. Gastritis is the most common factor accountable for this symptoms, followed by duodenitis and

Topics: Adolescent; Adult; Aged; Cross-Sectional Studies; Duodenitis; Dyspepsia; Female; Gastritis; Helicobacter Infections; Helicobacter pylori; Humans; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Pakistan; Risk Factors; Tacrolimus; Young Adult

Here we present a case report of a 41-year-old woman suffering from high fever and bacteremia due to Helicobacter canis, 11 months after kidney transplantation. Identification of H. canis was achieved by 16s rDNA sequence analysis of a positive blood culture. The patient was restored fully to health after antibiotics therapy (cefuroxime and ciprofloxacin). Until now, only 4 human clinical cases have been described with H. canis bacteremia. This study describes for the first time, to our knowledge, an infection with H. canis in a kidney transplant patient.

Topics: Adult; Anti-Bacterial Agents; Bacteremia; Cefuroxime; Ciprofloxacin; DNA, Bacterial; DNA, Ribosomal; Female; Graft Rejection; Helicobacter; Helicobacter Infections; Humans; Immunocompromised Host; Immunosuppressive Agents; Kidney Transplantation; Mycophenolic Acid; Prednisolone; Sequence Analysis, DNA; Tacrolimus

Topics: Area Under Curve; Azathioprine; Clarithromycin; Drug Administration Schedule; Drug Interactions; Duodenitis; Half-Life; Heart Transplantation; Helicobacter Infections; Humans; Male; Middle Aged; Omeprazole; Tacrolimus

To study Helicobacter pylori seroepidemiology before and after orthotopic liver transplantation.. Serum samples obtained from 118 liver transplant recipients before and after transplantation were examined for the presence of IgG antibodies to H. pylori whole cell extract and to the CagA protein of H. pylori.. Of 118 patients, 64 (54.2%) were H. pylori positive, and 36 (56.3%) of these had CagA antibodies. Of the 64 seropositive patients, 22 (34.4%) remained positive and 42 (65.6%) became negative for H. pylori antibodies a median of 39 months after transplantation. Patients who seroreverted showed a tendency to lower pretransplantation antibody levels and had received antibiotic therapy for at least 4 days. Seroreversion or antibody persistence was not affected by age, sex, CagA antibody status, CagA antibody titer, duration of antibiotic therapy, or immunosuppressive drugs administered after liver transplantation.. The prevalence of H. pylori infection, as detected by serological screening, in patients selected for liver transplantation is not different from that in the general population. In these patients, the seroprevalence of H. pylori drops after liver transplantation. This is largely due to the intake of antibiotics and immunosuppressants by transplant recipients. Seroreversion seems to be independent of the type of H. pylori bacteria.

Topics: Adult; Age Factors; Aminoglycosides; Anti-Bacterial Agents; Antibodies, Bacterial; Antigens, Bacterial; Azathioprine; Bacterial Proteins; Cephalosporins; Chi-Square Distribution; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Helicobacter Infections; Helicobacter pylori; Humans; Immunoenzyme Techniques; Immunoglobulin G; Immunosuppressive Agents; Liver Transplantation; Male; Penicillins; Prednisone; Prevalence; Seroepidemiologic Studies; Sex Factors; Tacrolimus; Time Factors