tacrolimus and Granuloma--Giant-Cell

A 45-year-old woman with personal history of hypertension presented with an erythematous lesion in the neckline for a year and with a progressive growth. A physical examination revealed an annular lesion with erythematous papules in the edge. Histological exam showed phagocytosis of elastic fibers by multinucleated cells compatible with annular elastolytic giant-cell granuloma. The patient did not present any other associated systemic manifestation. Treatment with tacrolimus 0.1 percent ointment was prescribed with a very good response after two months.

Topics: Erythema; Female; Granuloma, Giant Cell; Humans; Immunosuppressive Agents; Middle Aged; Skin Diseases; Tacrolimus

Papular elastolytic giant cell granuloma is an unusual variant of annular elastolytic giant cell granuloma. Its rarity makes the assessment of the real efficacy of any treatment difficult, as spontaneous remission is possible. We report a case whose interest, besides the rarity of the occurrence, rests in the pure papular expression of the clinical features, the association with a monoclonal gammopathy and the apparent efficacy of topical tacrolimus.

Topics: Adult; Female; Granuloma, Giant Cell; Humans; Immunosuppressive Agents; Paraproteinemias; Skin Diseases; Tacrolimus; Treatment Outcome

Topics: Administration, Cutaneous; Arm; Dermatologic Agents; Diagnosis, Differential; Drug Therapy, Combination; Female; Granuloma, Giant Cell; Humans; Hydroxychloroquine; Middle Aged; Skin Diseases; Tacrolimus