tacrolimus and Gingival-Hemorrhage

To compare oral health status between renal transplant recipients (RTRs) receiving tacrolimus (Tac) or everolimus (ERL) as immunosuppressive therapy.. This study is a cross-sectional study.. Thirty-six RTRs receiving Tac and 22 RTRs receiving ERL were included in the study. Age, gender, time since transplant and pharmacological data were recorded for both groups. Oral health status was assessed through the evaluation of teeth, periodontal parameters as well as saliva flow rate and pH.. RTRs receiving ERL were older than those receiving Tac. No differences were found between groups concerning oral hygiene habits, oral symptoms, smoking habits, unstimulated and stimulated saliva flow rate and pH, clinical attachment level or the number of decayed, missing and filled teeth. However, RTRs receiving ERL presented lower visible plaque index and lower values for bleeding on probing when compared to RTRs receiving Tac. In addition, RTRs receiving ERL presented a gingival index varying from normal to moderate inflammation whereas RTRs receiving Tac presented a gingival index varying from mild to severe inflammation.. RTRs receiving ERL have lower periodontal inflammation when compared to RTRs receiving Tac.

Topics: Adolescent; Adult; Age Factors; Aged; Allografts; Cross-Sectional Studies; Dental Plaque Index; DMF Index; Everolimus; Female; Gingival Hemorrhage; Health Status; Humans; Hydrogen-Ion Concentration; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Oral Health; Oral Hygiene; Periodontal Attachment Loss; Periodontal Index; Periodontitis; Saliva; Secretory Rate; Sirolimus; Smoking; Tacrolimus; Young Adult

The aim of this study was to determine the incidence and severity of gingival overgrowth (GO) induced by tacrolimus (Tcr) compared with ciclosporin A (CiA) in the absence of calcium channel blockers (CCB) in renal transplant recipients.. Forty patients (20 Tcr and 20 CiA) were evaluated before and 30 and 90 days after kidney transplantation. Demographic (age, gender) and periodontal parameters were recorded for all patients. Patients taking CCB at any time during the study were excluded from the investigation.. The mean GO score was significantly lower (p=0.014) in the Tcr group (6.4%) compared with the CiA group (17.9%) after 90 days of immunosuppressive therapy. At 90 days post-transplant, clinically significant GO was observed in four patients of the CiA group and in two of the Tcr group. This difference was not statistically significant (0.66).. No significant difference in the incidence of clinically significant GO was observed between the CiA and Tcr groups up to 90 days of immunosuppressive therapy.

Topics: Adult; Anti-Infective Agents; Azathioprine; Calcium Channel Blockers; Cyclosporine; Dental Plaque Index; Female; Follow-Up Studies; Gingival Hemorrhage; Gingival Overgrowth; Gingival Recession; Humans; Immunosuppressive Agents; Kidney Transplantation; Longitudinal Studies; Male; Middle Aged; Periodontal Index; Periodontal Pocket; Tacrolimus; Trimethoprim, Sulfamethoxazole Drug Combination