tacrolimus and Esophageal-Neoplasms

Topics: Antifungal Agents; Antineoplastic Agents; Candidiasis; Carcinoma; Esophageal Neoplasms; Female; Humans; Immunosuppression Therapy; Kidney Transplantation; Middle Aged; Recurrence; Tacrolimus; Treatment Outcome

Topics: Adult; Antiviral Agents; Colonic Neoplasms; Cyclosporine; Esophageal Neoplasms; Female; Ganciclovir; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Liver Neoplasms; Liver Transplantation; Lymphoproliferative Disorders; Middle Aged; Pharyngeal Neoplasms; Survival Analysis; Tacrolimus; Time Factors

The occurrence of an oesophageal squamous cell carcinoma following liver transplantation is very infrequent. Such an event has been related to a history of alcohol-induced cirrhosis, as in other squamous cell tumours of the oropharynx. We report the case of a 64-year-old male patient diagnosed as having oesophageal squamous cell carcinoma six years after having had a liver transplant due to alcohol-induced cirrhosis. The tumour was treated surgically and consisted of an Ivor-Lewis oesophagectomy. The patient is disease-free 17 months after surgery. A review of the cases reported in the literature indicated treatment with chemotherapy and radiation therapy, and with excision in some cases. Generally, despite aggressive treatment the prognosis is poor.

Topics: Alcoholism; Carcinoma, Squamous Cell; Cardia; Deglutition Disorders; Esophageal Neoplasms; Esophageal Stenosis; Esophagectomy; Humans; Immunocompromised Host; Immunosuppression Therapy; Immunosuppressive Agents; Liver Cirrhosis, Alcoholic; Liver Transplantation; Male; Middle Aged; Neoplasms, Multiple Primary; Postoperative Complications; Remission Induction; Stomach Neoplasms; Tacrolimus