tacrolimus and Enterocolitis--Pseudomembranous

George, a 55-year-old retired businessman with a diagnosis of myelofibrosis, underwent an allogeneic stem cell transplantation from his human leukocyte antigen-matched brother in June 2006. He was admitted to the hospital for a possible flare of graft-versus-host disease (GVHD) of the gut. His medications included tacrolimus, budesonide, and bechlamethasone for immunosuppression and pantoprazole. A stool sample was positive for Clostridium difficile toxin A on October 31, 2006, and he was started on oral metronidazole.

Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Beclomethasone; Biopsy; Budesonide; Clostridioides difficile; Colonoscopy; Enterocolitis, Pseudomembranous; Feces; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infection Control; Male; Metronidazole; Middle Aged; Oncology Nursing; Primary Myelofibrosis; Risk Factors; Tacrolimus; Vancomycin

Tacrolimus (FK506) has a superior immunosuppressive effect compared with cyclosporine (CSA) without a significant increase in generalized infectious complications. Differences in specific infections such as Clostridium difficile (CDI) have not been reported. We investigated the relationship between calcineurin inhibitors and CDI, hypothesizing that choice of calcineurin inhibitor (CSA or FK506) after lung transplantation would have no effect on the incidence of CDI.. We performed a retrospective chart review of lung transplant recipients between June 1, 2000, and December 31, 2005, at a single institution. Positive CDI assays through December 11, 2011, were also recorded. We used Student's t- and chi-squared tests (α = 0.05) to compare CSA and FK506 groups. We calculated adjusted hazard ratios for CDI using Cox proportional hazard models.. We identified 217 lung transplant recipients: 106 patients in the CSA group and 111 patients in the FK506 group. A total of 31 patients (27.9%) in the FK506 group developed CDI postoperatively compared with 20 patients (18.9%) in the CSA group (P = 0.16). The adjusted hazard ratio for CDI in the FK506 group was not significantly higher (1.53; 95% confidence interval, 0.78-2.98). There was no significant difference in the intensive care unit or total length of stay, in-hospital incidence rate, time to first CDI episode, or recurrence rate between groups.. The CDI rates were not significantly higher in the FK506 group than the CSA group in our study. These data are consistent with previous studies on FK506 that show no increase in infectious complications over CSA, and demonstrate its continued safety in lung transplantation.

Topics: Adolescent; Adult; Aged; Calcineurin Inhibitors; Child; Clostridioides difficile; Cyclosporine; Enterocolitis, Pseudomembranous; Female; Graft Rejection; Humans; Immunosuppressive Agents; Incidence; Lung Transplantation; Male; Middle Aged; Multivariate Analysis; Opportunistic Infections; Proportional Hazards Models; Retrospective Studies; Tacrolimus; Young Adult

Topics: Adult; Clostridioides difficile; Diarrhea; Enterocolitis, Pseudomembranous; Humans; Immunocompromised Host; Immunosuppressive Agents; Kidney Transplantation; Male; Tacrolimus