tacrolimus and Eczema--Dyshidrotic

Dyshidrotic palmoplantar eczema is a frequent disease often running a chronic relapsing course. Topical glucocorticosteroids form the mainstay of therapy, and alternatives are urgently warranted.. This study was performed to compare the efficacy of tacrolimus (FK506) 0.1% ointment and mometasone furoate 0.1% ointment in the treatment of dyshidrotic palmoplantar eczema.. Sixteen patients were included in the study after a randomized, observer-blind, intrapersonal comparison protocol. After a 2-week washout period, the active treatment phase amounted to 4 weeks with twice-daily topical application of test substances and additional use of emollients at will. Thereafter, patients were monitored at weekly intervals up to 8 weeks.. The dyshidrotic area and severity index showed a more than 50% reduction of baseline values after 2 weeks of active treatment both for FK506 (P =.003) and mometasone furoate (P =.022) in palmar areas. After active treatment, a nonsignificant increase in the dyshidrotic area and severity index was seen with FK506 treated areas. Fourteen of 16 patients had recurring symptoms requiring further therapy within 3 weeks after the active treatment phase.. Treatment with FK506 offers the possibility for rotational therapy with mometasone furoate in long-standing cases of chronic dyshidrotic palmar eczema.

Topics: Administration, Cutaneous; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents; Eczema, Dyshidrotic; Female; Foot Dermatoses; Glucocorticoids; Hand Dermatoses; Humans; Immunosuppressive Agents; Male; Middle Aged; Mometasone Furoate; Pregnadienediols; Severity of Illness Index; Single-Blind Method; Tacrolimus; Treatment Outcome

Topics: Administration, Topical; Aged; Biopsy; Dermatologic Agents; Eczema, Dyshidrotic; Follow-Up Studies; Foot; Hand; Humans; Male; Occlusive Dressings; Peptidylprolyl Isomerase; Severity of Illness Index; Tacrolimus; Time Factors

Topics: Dermatologic Agents; Diagnosis, Differential; Diagnostic Errors; Eczema, Dyshidrotic; Female; Humans; Immunosuppressive Agents; Middle Aged; Nursing Assessment; Patient Education as Topic; Physical Examination; Tacrolimus