tacrolimus and Carcinoma-in-Situ

Erythroplasia of Queyrat of the glans penis developed in a 79-year-old uncircumcised man on a background of biopsy proven Zoon's plasma cell balanitis affecting the same site on the glans. The Zoon's plasma cell balanitis had been treated with topical pimecrolimus for 1 month prior to the development of clinically evident erythroplasia of Queyrat. He was subsequently treated with topical 5-fluorouracil 5% for 2 weeks, which resulted in clinical clearance. He has since been circumcised.

Topics: Aged; Balanitis; Carcinoma in Situ; Carcinoma, Squamous Cell; Circumcision, Male; Erythroplasia; Humans; Immunosuppressive Agents; Male; Penile Neoplasms; Penis; Plasma Cells; Tacrolimus

To report a case of conjunctival intraepithelial neoplasia in a patient treated with tacrolimus after liver transplantation for hepatic carcinoma.. Description of the initial clinical presentation of a patient, tumor management, and 15-month follow-up.. A 70-year-old man presented with a conjunctival intraepithelial neoplasia that developed on the site of a preexisting pterygium. After total surgical removal and additional application of mitomycin, local tumor control was achieved.. We describe a case of intraepithelial conjunctival neoplasia in a patient treated with systemic tacrolimus. Local tumor control was achieved at 15 months after appropriate surgical management.

Topics: Aged; Antibiotics, Antineoplastic; Carcinoma in Situ; Combined Modality Therapy; Conjunctival Neoplasms; Humans; Immunosuppressive Agents; Liver Neoplasms; Liver Transplantation; Male; Mitomycin; Tacrolimus