tacrolimus and Calcinosis

tacrolimus has been researched along with Calcinosis* in 4 studies

Reviews

1 review(s) available for tacrolimus and Calcinosis

ArticleYear
Calcium pyrophosphate deposition (CPPD) in a liver transplant patient: are hypomagnesemia, tacrolimus or both guilty? A case-based literature review.
    Rheumatology international, 2022, Volume: 42, Issue:6

    Calcium pyrophosphate deposition (CPPD) can be induced by a persistent hypomagnesemia. Tacrolimus is an immunosuppressive treatment especially used in organ transplant, potentially inducer of hypomagnesemia by renal loss. A 53-year-old man, liver transplant 10 months earlier, developed an acute peripheral oligoarthritis of wrist, hip and elbow with fever, associated with acute low back pain. Synovial fluid was sterile, and revealed calcium pyrophosphate crystals. Spinal imaging showed inflammatory changes. Magnesium blood level was low at 0.51 mmol/l, with high fractional excretion in favor of renal loss. Tacrolimus was changed for everolimus, proton pump inhibitor was stopped, and magnesium oral supplementation was started. After 8 months follow-up and slow prednisone tapering, he did not relapse pain. Persistent hypomagnesemia is a rare secondary cause of CPPD. In this entity, drug liability should be investigated such as tacrolimus in organ transplant patient.

    Topics: Calcinosis; Calcium Pyrophosphate; Chondrocalcinosis; Humans; Liver Transplantation; Magnesium; Male; Middle Aged; Synovial Fluid; Tacrolimus

2022

Other Studies

3 other study(ies) available for tacrolimus and Calcinosis

ArticleYear
Multiple calcifications of fingers in patients with rheumatoid arthritis after intra-articular triamcinolone acetonide injections.
    Rheumatology (Oxford, England), 2021, 07-01, Volume: 60, Issue:7

    Topics: Aged; Arthritis, Rheumatoid; Calcinosis; Female; Finger Joint; Glucocorticoids; Hand Joints; Humans; Immunosuppressive Agents; Injections, Intra-Articular; Prednisolone; Tacrolimus; Triamcinolone Acetonide

2021
Decrease in kidney calbindin-D 28kDa as a possible mechanism mediating cyclosporine A- and FK-506-induced calciuria and tubular mineralization.
    Biochemical pharmacology, 1997, Mar-07, Volume: 53, Issue:5

    The use of the immunosuppressant cyclosporine A (CsA) is limited by its adverse renal effects. Most recently, we reported that the drug markedly decreases the levels of the calcium-binding protein calbindin-D 28kDa in kidneys of male Wistar rats. In the present study, the potential relationship between drug-induced nephrotoxicity and the decrease in kidney calbindin-D 28kDa was investigated. Four groups of male Wistar rats were treated for 10 or 31 days with either the immunosuppressant CsA (50 mg/kg/day), FK-506 (5 mg/kg/day), rapamycin (5 mg/kg/day) or with the nonimmunosuppressive cyclosporine derivative 3'keto-[Bmt1]-[Val2]-CsA (SDZ PSC-833) (50 mg/kg/day), and the effects on calcium homeostasis, kidney histology and renal calbindin-D 28kDa were examined. Similar effects were found with CsA and FK-506; both drugs strongly reduced kidney calbindin-D 28kDa protein levels, increased urine calcium excretion, caused intratubular calcification, and induced basophilic tubules. In contrast, rapamycin and SDZ PSC-833 caused no decrease in renal calbindin-D 28kDa levels, no noticeable alterations in calcium metabolism, and no renal calcification. The results provide evidence for a link between decreased renal calbindin, increased calcium urine excretion, and intratubular kidney calcification. The present data show no correlation between the decrease in renal calbindin and the induction of basophilic tubules; however, it needs to be investigated if these apparently independent kidney effects may have a common origin upstream of calbindin expression.

    Topics: Animals; Calbindins; Calcinosis; Calcium; Cyclosporine; Immunosuppressive Agents; Kidney; Kidney Tubules; Male; Polyenes; Rats; Rats, Wistar; S100 Calcium Binding Protein G; Sirolimus; Tacrolimus

1997
Clinicopathological evaluation of kidney transplants in patients given a fixed dose of FK 506. Japanese FK 506 Study Group.
    Transplantation proceedings, 1991, Volume: 23, Issue:6

    Topics: Biopsy; Calcinosis; Humans; Japan; Kidney Transplantation; Kidney Tubules, Proximal; Tacrolimus; Vacuoles

1991