tacrolimus and Brain-Damage--Chronic

An unusual case of inter-haemispheric disconnection syndrome occurring in a patient who had undergone hepatic transplantation is presented. The underlying disorder, at first wrongly interpreted as encephalitis, was found to be severe, diffuse cerebral vasculitis. The hypothesis that treatment with tacrolimus might have caused, or at least favoured the vascular damage is discussed.

Topics: Brain Damage, Chronic; Cerebral Angiography; Cerebral Infarction; Corpus Callosum; Disability Evaluation; Disease Progression; Fatal Outcome; Humans; Liver Transplantation; Magnetic Resonance Imaging; Male; Middle Aged; Split-Brain Procedure; Tacrolimus; Vasculitis

Topics: Adult; Bone Marrow Transplantation; Brain Damage, Chronic; Calcineurin; Calcineurin Inhibitors; Cyclosporine; Enzyme Inhibitors; Female; Hippocampus; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Magnetic Resonance Imaging; Memory Disorders; Neuropsychological Tests; Neurotoxicity Syndromes; Tacrolimus